Increasingly plastic pollution is being recognized as a critical environmental and human health threat of unprecedented scale and complexity. While trends in plastic production and consumption are still on the rise, the negative effects of uncollected, mismanaged, dumped or incinerated plastic waste are causing profound impacts on the environment, oceans, climate and food chains compromising the quality of life for humans and other living beings, with expected cumulative negative effects for the near future. Particularly populations in the Global South, where new markets for plastic consumer goods have rapidly emerged over the past 30 years, while waste management, in general, has remained precarious, underfunded or inexistent, directly experience the burdens of plastic pollution. The emerging environmental problems are particularly visible in these regions and so are also possible solutions and alternatives. Approximately 20 million informal workers already recover plastic waste from the garbage in the Global South, usually working under precarious, risky and poorly paid conditions. The literature claims that they represent a workforce that if recognized, integrated and valued and under decent work conditions and fair remuneration could potentially increase significantly the capturing of plastic waste and reduce the amount of fugitive plastics. This review paper applies an anthropogenic global environmental change theory lens to discuss the key challenges in managing plastic waste and global plastic pollution, uncovering major causes, impacts from dispersion and leakage of plastics into soil, water and air, recognizing the relational and geographic perspectives of plastic waste. A concerted effort is required to coordinating policies and technological solutions in order to strengthening, fund and recognize the waste picker sector as a key protagonist in addressing this waste issue.