While many species are affected by trafficking in their products, some take centre stage, including elephants, rhinos, pangolins and helmeted hornbills, and we report an open trade that continued in these items in eastern Myanmar between 2015 and 2020. We surveyed Myanmar’s border towns of Tachilek and Mong La, recording volumes, prices, origins and trade routes. We observed c. 16 500 ivory items, 8 helmeted hornbill casques and 264 beads, over 100 African rhino horn items and over 250 pangolins (mainly skins and scales). In 2020, asking prices in Mong La for rhino horn tips were US$10 770, rhino horn bracelets US$5385, helmeted hornbill casques US$2424 and big ivory bangles c. US$800, with prices being stable overall since 2017. We estimate the combined monetary values at US$0.25–0.30 million for Tachilek and US$0.75–2.00 million for Mong La. Mong La’s market today far surpasses Tachilek’s, being on the border of mainland China. Mobile phones and online trading allow customers to order items without bothering to cross the borders. Commitment to address the illegal wildlife trade across Myanmar’s borders requires a greater degree of cooperation and coordination amongst the relevant authorities in Myanmar, China and Thailand.