Advocates of global international relations (IR) present IR as a Eurocentric discipline that should now diversify its theoretical and empirical focus to the non-west. This paper turns this argument on its head, arguing that IR was ‘global at birth’. Concentrating in particular on the implications that global IR debate has for our understanding of the historical development of disciplinary knowledge, the article argues that both conventional and critical stances within this debate tend to express a substantialist conception of knowledge formations, one which encourages diffusionist ideas of the spread of knowledge from an origin to a destination, and essentialist representations of specific geographies of knowledge. In order to address this, the paper proposes a relational sociology of disciplinary knowledge that offers a more historically grounded understanding of the ongoing, provisional, connected, and configurational nature of knowledge construction, without losing sight of the hierarchies that inflect this. The article applies this framework to archival work on the intellectual history of international thought in India, offering an approach that allows a global account of the development of disciplinary IR that operates within and beyond imperial frames, encompassing the entangled histories of colonial, anti-colonial, and postcolonial lineages of what became known as ‘International Relations’ in the 20th century.