An area of influence method with biweekly destructive harvests 5 through 19 wk after planting (WAP) was used to monitor the reciprocal interference of common cocklebur and cotton in 1987 and 1988. Plant heights, leaf area, and leaf, stem, boll, fiber, and total plant biomass dry weights were measured in 15-cm increments away from common cocklebur or from a randomly selected cotton plant out to 105 cm. Data indicated that cotton less than 60 cm from common cocklebur was shorter, had less leaf area and lower leaf, stem, boll, and biomass dry weights than cotton beyond 60 cm from common cocklebur or cotton grown without common cocklebur interference. Differences in leaf area and biomass between cotton grown with and without common cocklebur interference were greater at and beyond 13 WAP sample dates than before 13 WAP. By 15 WAP, cotton leaf area and biomass were reduced an estimated 11% and 15%, respectively, averaged over the entire 105 cm of row. Cotton yield, harvested 27 WAP, was reduced an estimated 31% on plants grown with one common cocklebur plant per 2.1 m. Cotton yield was reduced on plants out to 99 cm from common cocklebur. Common cocklebur and cotton plants grown alone were taller, had greater leaf area, and greater leaf, stem, and biomass dry weight than those respective plants grown adjacent to cotton. Common cocklebur grown alone produced 67% more biomass than did cotton grown alone. Cotton plants grown adjacent to other cotton plants produced 89% and 96% less boll and fiber weight, respectively, than plants grown alone.