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2 results

  • Are there differential effects of fluoxetine in retarded/blunted affect versus agitated/anxious depressives? A clinical study

  • A Partiot, R Jouvent, A Pierson, P Baruch, JN Beuzen, S Ammar, D Widlöcher
  • Journal:
    European Psychiatry / Volume 12 / Issue 1 / 1997
    Published online by Cambridge University Press:
    16 April 2020, pp. 21-27
  • Background

    Clinical selectivity of antidepressants with pharmacological specificity still remains under debate.

    Method

    In the open trial presented below, the effects of fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), were compared across two groups of depressive inpatients contrasted on their symptomatological expression (agitated/anxious versus retarded/blunted affect). Sixteen patients (8 in each groups) were included in the 4-weeks treatment period and submitted to a weekly-based evaluation. Global depression, retardation, emotional blunting, agitation, anxiety and mood profile were assessed.

    Results

    Significant improvements of the HDRS and MADRS scores were observed in both groups. Although no group x treatment interaction was found on the global scores of depression, a differential effect according to the group was observed on anxiety, agitation, irritability and emotional lability.

    Discussion

    These preliminary results support the hypothesis that the effect of fluoxetine on positive clinical dimensions could lead to a differential effect in patients with agitation/anxiety when compared with patients with retardation/blunted affect.

  • Loss of automatic processes and blunted-affect in depression: a P3 study

  • A Partiot, A Pierson, J Le Houezec, V Dodin, B Renault, R Jouvent
  • Journal:
    European Psychiatry / Volume 8 / Issue 6 / 1993
    Published online by Cambridge University Press:
    16 April 2020, pp. 309-318

  • The P3 components (P3a and P3b) of the event-related potentials have been analysed in sixteen in-patients with a major depressive episode (DSM III-R) according to their subtype - anxious-agitated and impulsive versus retarded and blunted-affect - assuming that these two opposite dimensions of the depressive mood would rely on different physiopathological mechanisms. The P3a component, which indexes automatic cognitive processes, was dramatically decreased in the retarded and blunted-affect group. This suggests that this special type of cognitive dysfunction in depression is rather related to negative symptoms than to depression itself.