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Are there differential effects of fluoxetine in retarded/blunted affect versus agitated/anxious depressives? A clinical study

Published online by Cambridge University Press:  16 April 2020

A Partiot ,
R Jouvent ,
A Pierson ,
P Baruch ,
JN Beuzen ,
S Ammar  and
D Widlöcher
A Partiot
Affiliation:
Laboratoire Lilly France, 203, Bureaux de la Colline, 92213Saint-Cloud
R Jouvent*
Affiliation:
CNRS URA 1957
A Pierson
Affiliation:
Laboratoire Lilly France, 203, Bureaux de la Colline, 92213Saint-Cloud
P Baruch
Affiliation:
Département de Psychiatrie, Hôpital de l'Enfant-Jésus, 1401, 18e rue, Québec, G1J 1Z4, Canada
JN Beuzen
Affiliation:
Laboratoire Lilly France, 203, Bureaux de la Colline, 92213Saint-Cloud
S Ammar
Affiliation:
CNRS URA 1957
D Widlöcher
Affiliation:
Service de Psychiatrie Adulte, Hôpital de La Salpêtrière, Pavillon Clérambault, 47, boulevard de l'Hôpital, 75013Paris, France
*
*Correspondence and reprints: R Jouvent, CNRS URA 1957, Personnalité et Conduites Adaptives, Pavilion Clérambault, Hôpital de La Salpêtrière, 47, boulevard de l'Hôspital,75013 Paris, France.
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Summary

Background

Clinical selectivity of antidepressants with pharmacological specificity still remains under debate.

Method

In the open trial presented below, the effects of fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), were compared across two groups of depressive inpatients contrasted on their symptomatological expression (agitated/anxious versus retarded/blunted affect). Sixteen patients (8 in each groups) were included in the 4-weeks treatment period and submitted to a weekly-based evaluation. Global depression, retardation, emotional blunting, agitation, anxiety and mood profile were assessed.

Results

Significant improvements of the HDRS and MADRS scores were observed in both groups. Although no group x treatment interaction was found on the global scores of depression, a differential effect according to the group was observed on anxiety, agitation, irritability and emotional lability.

Discussion

These preliminary results support the hypothesis that the effect of fluoxetine on positive clinical dimensions could lead to a differential effect in patients with agitation/anxiety when compared with patients with retardation/blunted affect.

Keywords

depressionSSRIclinical dimensionsanxietyblunted-affectagitationretardationantidepressants
Type
Original article
Information
European Psychiatry , Volume 12 , Issue 1 , 1997 , pp. 21 - 27
Copyright
Copyright © Elsevier, Paris 1997

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