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Chapter 8 - General Pharmacology
- By David Convissar, Victoria Nguyen, Shaji Faisal, Ben Toure
Edited by Dharti Patel, Mount Sinai West and Morningside Hospitals, New York, Sang J. Kim, Hospital for Special Surgery, New York, Himani V. Bhatt, Mount Sinai West and Morningside Hospitals, New York, Alopi M. Patel, Rutgers Robert Wood Johnson Medical School, New Jersey
Book:

BASIC Essentials

Published online:

21 February 2025

Print publication:

13 March 2025, pp 41-44
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Summary

One of the core principles essential to an anesthesiologist’s fund of knowledge is that of general pharmacology. The aim of this chapter is to provide a foundation of key pharmacology principles necessary for the clinical application of anesthesia. The understanding of pharmacokinetics and pharmacodynamics is fundamental to maintaining anesthesia in a safe manner. This chapter will present basic pharmacological principles that govern anesthetic drug behavior, such as absorption, volume of distribution, clearance, metabolism, context sensitive half-time, extrahepatic modes of metabolism, and the impact of liver and renal dysfunction on anesthetic pharmacology.