Field experiments were conducted to determine the influence of growth stage on tolerance of seeded tomatoes (Lycopersicon esculentum Mill.) and of eastern black nightshade (Solanum ptycanthum Dun. #3 SOLPT) to the sodium salt of acifluorfen {5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid} at low use rates. Tomatoes as young as the 2 true-leaf stage exhibited some tolerance to acifluorfen at rates of 0.14 kg ae/ha and less. Rates of 0.28 and 0.56 kg/ha caused increased phytotoxicity; however, yield was not greatly reduced. At the 8-leaf stage, foliar injury was slight and existed only at the highest rates tested; however, tomato yields were reduced. Control of black nightshade at the 2-leaf stage was acceptable at rates as low as 0.14 kg/ha. When nightshade was at the 5-leaf stage, 0.28 and 0.56 kg/ha rates provided acceptable control − 87% and 96%, respectively. Nightshade in the 10-leaf stage was not controlled effectively at rates below 0.56 kg/ha.