The healthcare sector has proven to be supportive in stimulating health through contact with nature (Robinson and Breed, 2019; Kondo et al., 2020). Despite the positive practice examples, we see several challenges. There is no clear consensus or common understanding on quality assurance and health impact assessment of green care: there still is a wide range of approaches within different health expert communities and contexts, either with or without some form of qualified support such as coaching. As there is no ‘one size’ prescription fit for all, green care needs to be tailored to individual characteristics and circumstances, both of which are dynamic, e.g., in an environmental sense due to climate change, or related to socio-cultural dynamics (Beute et al., 2020a,b; Superior Health Council Belgium 2021). Sustainable health-related nature contact is not always easy to achieve especially when there is no follow-up with either healthcare professionals or other supporting organizations through social prescription. Accessibility of natural areas is often quite unequally distributed, with the more vulnerable often benefitting least, especially in urbanized areas. Another challenge is to achieve a reciprocal health relationship with nature: a stronger connection with nature and caring for nature helps to sustain a positive healthy relationship (O’Brien et al., 2010; Kurt et al., 2018), which may also contribute to nature conservation in a One Health perspective. As such, the healthcare sector can act as ambassadors for ‘One Healthy’ natural environments.