Mediterranean saltwort has become an established weed in the upper San Joaquin Valley and the Temblor Range areas of California. Fifteen herbicides were evaluated to determine their effects on 6- to 8-week-old plants grown in the greenhouse. Mediterranean saltwort was killed by chlorsulfuron3, hexazinone, and metribuzin at low rates. Triclopyr4 (Garlon 3A and Garlon 4), atrazine, imazapyr, glyphosate, dicamba, bromacil, karbutilate, and simazine were effective at higher rates. Four herbicides, asulam, pendimethalin, amitrole, and fosamine, did not kill Mediterranean saltwort at the rates tested.