Greenhouse studies showed that the mixed function oxidase inhibitor, piperonyl butoxide (PBO), tank-mixed with the sulfonylurea herbicides, nicosulfuron, primisulfuron, and thifensulfuron, in the absence of effective adjuvants enhanced herbicide activity on both broadleaf and grass weed species. Effective adjuvants for nicosulfuron were K-3000 for common lambsquarters, Sylgard® 309 Surfactant for velvetleaf, K-2000 for barnyardgrass, and K-2000, K-3000, and Scoil® methylated seed oil for giant foxtail control. K-3000 and Sylgard 309 enhanced velvetleaf control with primisulfuron and thifensulfuron. The 28% urea and ammonium nitrate (UAN) was more effective as an adjuvant with thifensulfuron for velvetleaf than for common lambsquarters control. The enhancement of sulfonylurea herbicide activity with PBO was most apparent when other adjuvants were least effective.