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1 results

  • Early development and unstable genes in schizophrenia: preliminary results

  • Agnes Ayton, Alex G. Morris, Philip J. Tyson, David Hunt, Ann M. Mortimer, David Cottrell
  • Journal:
    European Psychiatry / Volume 17 / Issue 6 / October 2002
    Published online by Cambridge University Press:
    16 April 2020, pp. 332-338
  • Background.

    Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.

    Aims.

    To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.

    Method.

    Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.

    Results.

    There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.

    Conclusions.

    CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.