Early canopy closure and manipulation of crop row spacing or density can reduce the amount and frequency of herbicide use in corn. Field studies were conducted at Woodstock, ON from 1996 to 1999 to evaluate the effect of corn row spacing, plant density, and frequency of glufosinate application on weed biomass and corn yield in glufosinate-resistant corn. Treatments included row width, corn density, and herbicide. The effect of row width and corn density on weed biomass was variable among years. In a wet year (1996), narrow (38 cm) rows provided greater weed suppression than wide (76 cm) rows regardless of crop density. In a dry year (1998), narrow-row high-density (100,000 plants/ha) corn had the lowest weed biomass. In other years, either narrow row or high density was equally successful in suppressing weeds. Effectiveness of herbicides in reducing weed biomass was not influenced by row width or corn density. Corn yield was influenced by row width or corn density. Although weed biomass was lowered by two applications of glufosinate in comparison with a single application, corn grain yields were similar between the two treatments. Planting corn at higher densities may help in reducing early-season weed competition, whereas narrow rows may help in controlling later-emerging species.