We describe a simple method for computer quantification
of eye movement (EM) potentials during REM sleep. This
method can be applied by investigators using either period-amplitude
(PA) or Fast Fourier Transform (FFT) spectral EEG analysis
without special hardware or computer programming. It provides
good correlations with visual ratings of EM in baseline
sleep and after administration of GABAergic hypnotics.
We present baseline data for both PA and FFT measures for
16 normal subjects, studied for 5 consecutive nights. Both
visually rated and computer-measured EM density (EMD) showed
high night-to-night correlations across baseline and drug
nights and the computer measures detected the EMD suppression
that is produced by GABAergic drugs. Measurement of EM
in addition to stage REM provides biologically significant
information and application of this simple computer method,
which does not require pattern recognition algorithms or
special hardware, could provide reliable data that can
be compared across laboratories.