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Non-Mendelian etiologic factors in neuropsychiatric illness: Pleiotropy, epigenetics, and convergence

Published online by Cambridge University Press:  24 October 2012

Curtis K. Deutsch  and
William J. McIlvane
Curtis K. Deutsch
Affiliation:
Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452. [email protected]@umassmed.edu
William J. McIlvane
Affiliation:
Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452. [email protected]@umassmed.edu
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Abstract

The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 35 , Issue 5 , October 2012 , pp. 363 - 364
Copyright
Copyright © Cambridge University Press 2012 

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