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Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea

Published online by Cambridge University Press:  06 March 2023

A S Jaiswal Open the ORCID record for A S Jaiswal [Opens in a new window] ,
B V Valappil ,
Y Gupta ,
K Sikka Open the ORCID record for K Sikka [Opens in a new window] ,
A Thakar  and
H Verma Open the ORCID record for H Verma [Opens in a new window]
A S Jaiswal
Affiliation:
Otorhinolaryngology and Head-Neck Surgery, New Delhi, India
B V Valappil
Affiliation:
Otorhinolaryngology and Head-Neck Surgery, New Delhi, India
Y Gupta
Affiliation:
Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
K Sikka
Affiliation:
Otorhinolaryngology and Head-Neck Surgery, New Delhi, India
A Thakar
Affiliation:
Otorhinolaryngology and Head-Neck Surgery, New Delhi, India
H Verma*
Affiliation:
Otorhinolaryngology and Head-Neck Surgery, New Delhi, India
*
Corresponding author: Dr Hitesh Verma; E-mail: [email protected]
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Abstract

Objective

To evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea.

Methods

A prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy failed or was refused. All patients underwent polysomnography and serum insulin-like growth factor 1 evaluation pre-operatively and at three months post-operatively. The site of surgery was determined using Müller's manoeuvre and ApneaGraph AG 200.

Results

Fifteen patients were included with a mean age of 38 years: 11 males and 4 females. The mean pre-operative Apnoea–Hypopnoea Index using polysomnography was 53.7 events per hour, and the mean post-operative Apnoea–Hypopnoea Index at three months was 15.3 events per hour (p = 0.0001). The mean pre-operative serum insulin-like growth factor 1 was 160.2 μg/l, while the mean post-operative value was 236.98 μg/l (p = 0.005).

Conclusion

In adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy fails, site-specific surgical intervention to treat the obstruction leads to an increase in serum insulin-like growth factor 1 levels.

Keywords

Polysomnographyinsulin-like growth factormetabolic syndromeobstructive sleep apneaobesity
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 11 , November 2023 , pp. 1222 - 1225
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr H Verma takes responsibility for the integrity of the content of the paper

References

Chen, LD, Lin, L, Huang, JF, Chen, X, Xu, QZ, Liu, JN. Effect of continuous positive airway pressure on insulin growth factor-1 in patients with obstructive sleep apnea: a meta-analysis. Growth Horm IGF Res 2015;25:75–9CrossRefGoogle ScholarPubMed
Punjabi, NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 2008;5:136–43CrossRefGoogle ScholarPubMed
Blum, WF, Albertsson-Wikland, K, Rosberg, S, Ranke, MB. Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion. J Clin Endocrinol Metab 1993;76:1610–16Google ScholarPubMed
Boulware, SD, Tamborlane, WV, Rennert, NJ, Gesundheit, N, Sherwin, RS. Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults. J Clin Invest 1994;93:1131–9CrossRefGoogle Scholar
Sesti, G, Sciacqua, A, Cardellini, M, Marini, MA, Maio, R, Vatrano, M et al. Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance. Diabetes Care 2005;28:120–5CrossRefGoogle ScholarPubMed
Sandhu, MS, Heald, AH, Gibson, JM, Cruickshank, JK, Dunger, DB, Wareham, NJ. Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet 2002;359:1740–5CrossRefGoogle ScholarPubMed
Izumi, S, Ribeiro-Filho, FF, Carneiro, G, Togeiro, SM, Tufik, S, Zanella, MT. IGF-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea. J Clin Sleep Med 2016;12:487–93CrossRefGoogle ScholarPubMed
Zhu, J, Fang, Y, Wang, HF, Chen, X, Yu, DJ, Shen, Y. Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 concentrations in children with obstructive sleep apnea-hypopnea syndrome. Respir Care 2015;60:593–602CrossRefGoogle ScholarPubMed
Ursavas, A, Karadag, M, Ilcol, YO, Ercan, I, Burgazlioglu, B, Coskun, F et al. Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome. Lung 2007;185:309–14CrossRefGoogle ScholarPubMed
Grunstein, RR, Handelsman, DJ, Lawrence, SJ, Blackwell, C, Caterson, ID, Sullivan, CE. Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy. J Clin Endocrinol Metab 1989;68:352–8CrossRefGoogle ScholarPubMed
Gianotti, L, Pivetti, S, Lanfranco, F, Tassone, F, Navone, F, Vittori, E et al. Concomitant impairment of growth hormone secretion and peripheral sensitivity in obese patients with obstructive sleep apnea syndrome. J Clin Endocrinol Metab 2002;87:5052–7CrossRefGoogle ScholarPubMed
Juul, A, Scheike, T, Davidsen, M, Gyllenborg, J, Jørgensen, T. Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation 2002;106:939–44CrossRefGoogle ScholarPubMed
Janssen, JA, Stolk, RP, Pols, HA, Grobbee, DE, Lamberts, SW. Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease. Arterioscler Thromb Vasc Biol 1998;18:277–82. Erratum in: Arterioscler Thromb Vasc Biol 1998;18:1197CrossRefGoogle Scholar
Coughlin, SR, Mawdsley, L, Mugarza, JA, Calverley, PM, Wilding, JP. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J 2004;25:735–41CrossRefGoogle ScholarPubMed
Gruber, A, Horwood, F, Sithole, J, Ali, NJ, Idris, I. Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state. Cardiovasc Diabetol 2006;5:22CrossRefGoogle Scholar