National interest in the effects of the U.S. food system has risen to such a level that the Institute of Medicine (IOM) and National Research Council (NRC) of the National Academies was compelled recently to publish A Framework for Assessing Effects of the Food System (IOM/NRC 2015), focusing on health, environmental, and economic and social variables. While providing a useful framework, the volume stopped short of actually carrying out studies to validate or test the assumptions of the framework. In addition to having measurable societal effects, food systems are also being affected by powerful secular forces that range from rising income inequality, consolidation and rationalization in retailing, consumer preferences for local and regional foods, to changes in climate and competition for land associated with urbanization. In parallel, an expanding “food movement” has emerged that, with little formal or rigorous analysis, has become highly critical of the food system and its consequent health, environmental, and economic and social effects.