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Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid supplementation on maternal reproductive parameters

Published online by Cambridge University Press:  23 September 2022

Danielle Storino de Freitas ,
Guilherme Antonio de Gouvêa Lopes ,
Barbara Rodrigues Nascimento ,
Breno Augusto Magalhães Open the ORCID record for Breno Augusto Magalhães [Opens in a new window] ,
Ana Paula Madureira  and
Paulo Henrique Almeida Campos-Junior Open the ORCID record for Paulo Henrique Almeida Campos-Junior [Opens in a new window]
Danielle Storino de Freitas
Affiliation:
Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei. São João del-Rei, Minas Gerais, Brazil
Guilherme Antonio de Gouvêa Lopes
Affiliation:
Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei. São João del-Rei, Minas Gerais, Brazil
Barbara Rodrigues Nascimento
Affiliation:
Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei. São João del-Rei, Minas Gerais, Brazil
Breno Augusto Magalhães
Affiliation:
Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei. São João del-Rei, Minas Gerais, Brazil
Ana Paula Madureira
Affiliation:
Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei. São João del-Rei, Minas Gerais, Brazil
Paulo Henrique Almeida Campos-Junior*
Affiliation:
Laboratório de Pesquisa em Reprodução e Desenvolvimento, Universidade Federal de São João del Rei. São João del-Rei, Minas Gerais, Brazil
*
Author for correspondence: Paulo Henrique Almeida Campos-Junior. Universidade Federal de São João del Rei. Praça Dom Helvécio, 74 – Dom Bosco, São João del-Rei, MG, 36301-160, Brazil. E-mail: [email protected]
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Summary

Conjugated linoleic acid (CLA) is a mixture of positional isomers of linoleic acid found in ruminant products and meat. The diet supplementing with CLA is an emerging area, requiring studies to elucidate its effects on animals and human reproduction, as well as its side effects. Therefore, the aim of this study was to evaluate the effects of CLA gastric administration, during the pregestational and gestational period in biometric and reproductive parameters, as well as in ovarian morphophysiology. Animals were distributed in three groups: (1) control (n = 10); (2) fish oil (n = 10); and (3) CLA (n = 10), that daily received, by gavage, phosphate-buffered saline, fish oil and CLA, respectively, carried out over 50 days (before mating, mating and pregnancy). There was an increment in the nasoanal distance and Lee index of the CLA and fish oil-treated groups during the first weeks (P > 0.05). CLA administration did not affect the ovarian follicle mobilization (P > 0.05), the number of follicles (P > 0.05) and the integrated density of lipid content of oocytes included in antral follicles (P > 0.05). There was no effect of CLA administration on the litter weight (P > 0.05; F2 and F3), however, an increment (P < 0.05) in the number of pups per litter (F2) was observed. Overall, this study demonstrated the absence of side effects of the CLA gastric administration on mice reproductive performance and suggests that this treatment would transgenerationally enhance fertility in this species.

Keywords

CLAFertilityFolliculogenesisNutritionOvary
Type
Research Article
Information
Zygote , Volume 30 , Issue 6 , December 2022 , pp. 863 - 871
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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