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Nutritional and osmoregulatory functions of betaine

Published online by Cambridge University Press:  18 September 2007

M.T. Kidd*
Affiliation:
Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27695-7608, USA
P.R. Ferket
Affiliation:
Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27695-7608, USA
J.D. Garlich
Affiliation:
Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27695-7608, USA
*
*Nutri-Quest Inc., 1400 Eldbridge Payne Road, Suite 110, Chesterfield, MO 63017, USA.
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Abstract

Betaine, a donor of labile methyl groups, can spare choline and methionine but cannot replace these compounds in poultry diets. Betaine is synthesized from choline by choline oxidase and it can donate methyl groups to homocysteine to form methionine. Physiologically, betaine is one of several compounds used by cells to regulate osmotic pressure. Among the potential benefits of its inclusion in poultry feeds are sparing choline, carcass fat reduction and aiding cell osmoregulation. Some feed ingredients are natural sources of betaine per se. This review considers the metabolism, functions and applications of betaine in poultry.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1997

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References

Almquist, H.J. and Grau, C.R. (1943) Growth-promoting activity of betaine in the chick. Journal of Biological Chemistry 149: 575576CrossRefGoogle Scholar
Almquist, H.J. and Grau, C.R. (1944) Interrelationship of methionine, choline, betaine, and arsenocholine in the chick. Journal of Nutrition 27: 263269CrossRefGoogle Scholar
Bagnasco, S., Balaban, R., Fales, H.M., Yang, Y. and Burg, M. (1986) Predominant osmotically active organic solutes in rat and rabbit renal medullas. Journal of Biological Chemistry 261: 58725877CrossRefGoogle ScholarPubMed
Baker, D.H. (1977) Sulfur in nonruminant nutrition. National Feed Ingredient Association Review, pp. 123Google Scholar
Barak, A.J. and Tuma, D.J. (1983) Betaine, metabolic by-product or vital methylating agent? Life Sciences 32: 771774CrossRefGoogle ScholarPubMed
Bell, A. (1995) What's the word on betaine? Pork95, February, pp. 2627Google Scholar
Burg, M.B. (1994) Molecular basis for osmoregulation of organic osmolytes in renal medullary cells. Journal of Experimental Zoology 268: 171175CrossRefGoogle ScholarPubMed
Cantey, J.R. (1993) Escherichia coli diarrhea. Gastroenterology Clinics of North America 22: 609622.CrossRefGoogle ScholarPubMed
Chadwick, A., Rapson, E.B., Carlos, G.M. and Lee, D.L. (1985) Circulating prolactin concentrations in chickens infected with Eimeria tenella. British Poultry Science 26: 1723CrossRefGoogle ScholarPubMed
Chambelaine, M.E. and Strange, K. (1989) Anisosmotic cell volume regulation: a comparative review. American Journal of Physiology 257 (Cell Physiology 26): C159–C173Google Scholar
Chambers, S.T. and Kunin, C.M. (1985) The osmoprotective properties of urine for bacteria: The protective effect of betaine and human urine against low pH and high concentrations of electrolytes, sugars, and urea. Journal of Infectious Diseases 152: 13081316CrossRefGoogle Scholar
Chambers, S.T. and Kunin, C.M. (1987) Osmoprotective activity for Escherichia coli in mammalian renal inner medulla and urine. Journal of Clinical Investigation 80: 12551260CrossRefGoogle ScholarPubMed
Chapman, H.D. (1988) Strategies for the control of coccidiosis in chickens. World's Poultry Science Journal 44: 187192CrossRefGoogle Scholar
Combs, G.F. (1992) The vitamins: fundamental aspects in nutrition and health. In: Quasi-Vitamins, Academic Press, New York, pp. 393431Google Scholar
Daily, J.W. and Sachan, D.S. (1995) Choline supplementation alters carnitine homeostasis in humans and guinea pigs. Journal of Nutrition 125: 19381944CrossRefGoogle ScholarPubMed
Dick, D.A.T. (1958) Osmotic equilibria in fibroblasts in tissue culture measured by immersion refractometry. Proceedings of Royal Society of London B 149: 130143Google ScholarPubMed
Dick, D.A.T. (1979) Structural and properties of water in the cell. In: Mechanisms of Osmoregulation in Animals (Ed. Gilles, R.), John Wiley and Sons, New York, pp. 345Google Scholar
Dragolovich, J. (1994) Dealing with salt stress in animal cells: the role and regulation of glycine betaine concentrations. Journal of Experimental Zoology 168: 139144CrossRefGoogle Scholar
De Ridder, J.J.M. and Van Dam, K. (1973) The efflux of betaine from rat-liver mitochondria, a possible regulating step in choline oxidation. Biochimica et Biophysica Acta 291: 557563CrossRefGoogle ScholarPubMed
De Ridder, J.J.M. and Van Dan, K. (1975) Control of choline oxidation by rat-liver mitochondria. Biochimica et Biophysica Acta 408: 112122CrossRefGoogle ScholarPubMed
Du Vigneaud, V., Chandler, J.P., Moyer, A.W. and Keppel, D.M. (1939) The effect of choline on the ability of homocystine to replace methionine in the diet. journal of Biological Chemistry 131: 5776CrossRefGoogle Scholar
Ensingmer, A.H., Ensminger, M.E., Konlande, J.E. and Robson, J.R.K. (1986) Choline. In: Food for Health: A Nutrition Encyclopedia, Pegus Press, Clovis, California, pp. 194196.Google Scholar
Ferket, P.R. (1995) Flushing syndrome in commercial turkeys during the grow-out stage. In: Proceedings, Smithkline Beeclzain Pacesetter Conference, National Turkey Federation Annual Meeting, 10 January, pp. 514Google Scholar
Finkelstein, J.D., Martin, J.J., Harris, B.J. and Kyle, W.E. (1982) Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochemical and Biophysical Research Communications 108: 344348CrossRefGoogle ScholarPubMed
Finkelstein, J.D., Martin, J.J., Harris, B.J. and Kyle, W.E. (1983) Regulation of hepatic-homocysteine methyltransferase by dietary betaine. Journal of Nutrition 113: 519521CrossRefGoogle Scholar
Fondacaro, J.D. (1986) Intestinal ion transport and diarrheal disease. American Journal of Physiology 250 (Gasrointestinal Liver Physiology 13) Gl–G8Google ScholarPubMed
Gilles, R. (1979) Intracellular organic osmotic effectors. In: Mechanisms of Osmoregulation in Animals (ed. Gilles, R.), John Wiley and Sons, New York, pp. 111154Google Scholar
Gwyther, M.J. and Britton, W.M. (1989) The influence of coccidial infections and ionophore treatment on tissue cations and anions in broiler chicks. In: Coccidia and Intestinal Coccidiomorphs, INRA Publication, Tours, France, pp. 279284Google Scholar
Handler, J.S. and Kwon, H.M. (1993) Regulation of renal cell organic osmolyte transport by tonicity. American journal of Physiology 265 (Cell Physiology) 34: C1449–C1455CrossRefGoogle ScholarPubMed
Hanson, A.D., Rathinasabapathi, B., Rivoal, J., Burnet, M., Dillon, M.O., Gage, D.A. (1994) Osmoprotective compounds in the Plumbaginacae: a natural experiment in metabolic engineering of stress tolerance. Proceedings of the National Academy of Sciences USA 91: 306310CrossRefGoogle ScholarPubMed
Hegsted, D.M., Milles, R.C., Elvehjem, C.A. and Hart, E.B. (1941) Choline in the nutrition of chicks. Journal of Biological Chemistry 138: 459466CrossRefGoogle Scholar
Hippel, P.H., Von and Schleich, T. (1969) The effects of neutral salts on the structure and conformational stability of macromolecules. In: Structure and Stability of Biological Macromolecules (Eds Timsheff, S.N. and Fasman, G.D.), Dekker, New York, pp. 417569Google Scholar
Imhoff, J.F. and Rodriguez-Valera, F. (1984) Betaine is the main compatible solute of halophilic eubacteria. Journal of Bacteriology 160: 478479CrossRefGoogle ScholarPubMed
Jukes, T.H. and Welch, A.D. (1942) The effect of certain analogues of choline on perosis. Journal of Biological Chemistry 146: 1924CrossRefGoogle Scholar
Keshavarz, K. and Austic, R.E. (1985) An investigation concerning the possibility of replacing supplemental methionine with choline in practical laying rations. Poultry Science 64: 114118CrossRefGoogle Scholar
Law, R.O. and Burg, M.B. (1991) The role of organic osmolytes in the regulation of mammalian cell volume. In: Advances in Comparative and Environmental Physiology Vol. 9, Volume and Osmolality Control in Animal Cells (Eds Gilles, R., Hoffmann, E.K. and Bolis, L.), Springer-Verlag, New York, pp. 189225CrossRefGoogle Scholar
Le Rudulier, D., Strom, A.R., Dandekar, A.M., Smith, L.T. and Valentine, R.C. (1984) Molecular biology of osmoregulation. Science 224: 10641068CrossRefGoogle ScholarPubMed
Lombardi, B., Pani, P. and Schlunk, F.F. (1968) Choline-deficiency fatty liver: impaired release of hepatic triglycerides. Journal of Lipid Research 9: 437446CrossRefGoogle ScholarPubMed
Lowry, K.R., Izquierdo, Q.A. and Baker, D.H. (1987) Efficacy of betaine relative to choline as a methyl donor. Poultry Science 55 (Supplement 1): 135Google Scholar
Lucas, H.L., Norris, L.C. and Heuser, G.F. (1946) Observations on the choline requirements of hens. Poultry Science 25: 373375CrossRefGoogle Scholar
Mann, P.J.G., Woodward, H.E. and Quastel, J.H. (1938) Hepatic oxidation of choline and arsenocholine. Biochemistry Journal 32: 10241032CrossRefGoogle ScholarPubMed
Mcdougald, L.R. and Reid, W.M. (1991) Coccidiosis. In: Diseases of Poultry (Ed. Calnek, B.W.), 9th ed. Iowa State University Press, Ames, Iowa, pp. 780797Google Scholar
Mcginnis, J., Norris, L.C. and Heuser, G.F. (1942) Effect of ethanolamine and betaine on perosis in chicks. Experimental Biology and Medicine 51: 293294CrossRefGoogle Scholar
Molitoris, B.A. and Baker, D.H. (1976) The choline requirement of broiler chicks during the seventh week of life. Poultry Science 55: 220224CrossRefGoogle ScholarPubMed
Nakanishi, T., Balaban, R.S. and Burg, M.B. (1988) Survey of osmolytes in renal cell lines. American Journal of Physiology 255 (Cell Physiology 24): C181–C191CrossRefGoogle ScholarPubMed
Nakanishi, T., Turner, R.J. and Burg, M.B. (1990) Osmoregulation of betaine transport in mammalian renal medullary cells. American Journal of Physiology 258 (Renal Fluid Electrolyte Physiology 27): F1061–F1067Google ScholarPubMed
Nesheim, M.C., Norvell, M.J., Ceballos, E. and Leach, R.M. Jr. (1971) The effect of choline supplementation of diets for growing pullets and laying hens. Poultry Science 50: 820831CrossRefGoogle ScholarPubMed
Parsons, C.M. and Leeper, R.W. (1984) Choline and methionine supplementation of layer diets varying in protein content. Poultry Science 63: 16041609CrossRefGoogle ScholarPubMed
Pellerdy, L.P. (1974) Coccidia and Coccidiosis. 2nd ed. Akademiai Kiado, Budapest, Hungary and Paul Parey, Berlin, Germany.Google Scholar
Pesti, G.M., Harper, A.E. and Sunde, M.L. (1979) Sulfur amino acid and methyl donor status of corn-soy diets fed to starting broiler chicks and poults. Poultry Science 58: 15411547CrossRefGoogle ScholarPubMed
Pesti, G.M., Harper, A.E. and Sunde, M.L. (1980) Choline/methionine nutrition of starting broiler chicks. Three models for estimating the choline requirement with economic considerations. Poultry Science 59: 10731081CrossRefGoogle ScholarPubMed
Pesti, G.M., Benevenga, N.J., Harper, A.E. and Sunde, M.L. (1981) Factors influencing the assessment of the availability of choline in feedstuffs. Poultry Science 60: 188196CrossRefGoogle ScholarPubMed
Petronini, P.G., Deangelis, E.M., Borghetti, P., Borghetti, A.F. and Wheeler, K.P. (1992) Modulation by betaine of cellular responses to osmotic stress. Biochemistry Journal 282: 6973CrossRefGoogle ScholarPubMed
Petronini, P.G., Deangelis, E.M., Borghetti, A.F. and Wheeler, K.P. (1994) Osmotically inducible uptake of betaine via amino acid transport system A in SV-3T3 cells. Biochemistry Journal 300: 4550CrossRefGoogle ScholarPubMed
Robertson, J.D. (1965) Studies on the chemical composition of muscle tissue. 111. The mantle muscle of cephalopod mollusks. Journal of Experimental Biology 42: 153175CrossRefGoogle Scholar
Ruiz, N., Miles, R.D. and Harms, R.H. (1983) Choline, methionine, and sulfate interrelationships in poultry nutrition: a review. World/s Poultry Science Journal 39: 185198Google Scholar
Saunderson, C.L. and Mackinlay, J. (1990) Changes in body-weight, composition and hepatic enzyme activities in response to dietary methionine, betaine and choline levels in growing chicks. British Journal of Nutrition 63: 339349CrossRefGoogle ScholarPubMed
Schexnailder, R. and Griffith, M. (1973) Liver fat and egg production of laying hens influenced by choline and other nutrients. Poultry Science 52: 11881194CrossRefGoogle ScholarPubMed
Scott, M.L., Nesheim, M.C. and Young, R.J. (1982) The vitamins. In: Nutrition of the Chicken. M.L. Scott and Associates, Ithaca, New York, pp. 119276Google Scholar
Shoemaker, V.H. (1972) Osmoregulation and excretion in birds. In: Avian Biology, Vol. II. (Eds Farner, D.S., King, J.R. and Parkes, K.C.), Academic Press, New York, pp. 527574CrossRefGoogle Scholar
Staurnes, M. and Eliassen, R. (1986) Smoltifisering og sjovannstoleranse II. (Smoltification and seawater tolerance II.) Norsk Fiskeoppdrett 9: 5253Google Scholar
Stekol, J.A., Hsu, P.T., Weiss, S. and Smith, P. (1953) Labile methyl group and its synthesis denovo in relation to growth in chicks. Journal of Biological Chemistry 203: 763773CrossRefGoogle Scholar
Stryer, L. (1988) Biosynthesis of amino acids and heme. In: Biochemistry, 3rd ed, W.H. Freeman and Company, New York, pp. 575626Google Scholar
Sutherland, L., Cairney, J., Elmore, M., Booth, I. and Higgins, C. (1986) Osmotic regulation of transcription: induction of the proU betaine transport gene is dependent on accumulation of intracellular potassium. Journal of Bacteriology 168: 805814CrossRefGoogle ScholarPubMed
Tyler, D.D. (1977) Transport and oxidation of choline by liver mitochondria. Biochemistry Journal 166: 571581CrossRefGoogle ScholarPubMed
Virtanen, E., Junnila, M. and Soivio, A. (1989) Effects of food containing betaine/amino acid additive on the osmotic adaptation of young atlantic salmon, Salmo salar L. Aquaculture 83: 109122CrossRefGoogle Scholar
Vertanen, E. (1993) Analyzed values for betaine in feedstuffs. Personal communication, Finnsugar Bioproducts, Helsinki, Finland.Google Scholar
Voet, D. and Voet, J.G. (1995) Transport through membranes. In: Biochemistry, 2nd ed., John Wiley and Sons, New York, pp. 484505Google Scholar
Westberg, J.K. (1951) Betaine in the nutrition of chickens and turkeys. International Minerals and Chemical Corporation, Chicago, Illinois, pp. 3Google Scholar
Wolford, J.H. and Polin, D. (1975) Effect of inositol, lecithin, vitamins (812 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens. Poultry Science 54: 981991CrossRefGoogle Scholar
Wright, S.H., Wunz, T.M. and Silva, A.L. (1992) Betaine transport in the gill of a marine mussel, Mytilus cafifornianus. American Journal of Physiology 263 (Regulatory Integrative Comparative Physiology 32): R226–R232Google Scholar
Wunz, T.M. and Wright, S.H. (1993) Betaine transport in rabbit and renal brush-border membrane vesicles. Biochimica et Biophysica Acta 1062: 123132Google Scholar
Yancey, P.H. and Burg, M.B. (1989) Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis. American Journal of Physiology 257 (Renal Fluid Electrolyte Physiology 26): F602–F607Google ScholarPubMed
Yancey, P.H. and Burg, M.B. (1990) Counteracting effects of urea and betaine in mammalian cells in culture. American Journal of Physiology 258 (Regulatory Integrative Comparative Physiology 27): R198–R204Google ScholarPubMed
Yancey, P.H. and Somero, G.H. (1979) Counteracting of urea destabilization of protein structureby methylamine osmoregulatory compounds of elasmobranch fishes. Biochemical Journal 183: 317323CrossRefGoogle Scholar
Yancey, P.H., Clark, M.E., Hand, S.C., Bowlus, R.D. and Somero, G.N. (1982) Living with water stress: evolution of osmolyte systems. Science 217: 12141222CrossRefGoogle ScholarPubMed
Yao, Z. and Vance, D.E. (1989) Head group specificity in the requirement of phosphatidylcholine biosynthesis for very low density lipoprotein secretion from cultured hepatocytes. Journal of Biological Chemistry 264: 1137311380CrossRefGoogle ScholarPubMed
Zeisel, S.H. (1981) Dietary choline: biochemistry, physiology, and pharmacology. Annual Reviezu of Nutrition 1: 95121CrossRefGoogle ScholarPubMed