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Radiofrequency tumor ablation system with a wireless or implantable probe

Published online by Cambridge University Press:  12 August 2020

Julian Moore ,
Sheng Xu ,
Bradford J. Wood ,
Hongliang Ren  and
Zion Tsz Ho Tse Open the ORCID record for Zion Tsz Ho Tse [Opens in a new window]
Julian Moore
Affiliation:
School of Electrical and Computer Engineering, The University of Georgia, Athens, GA30602, USA
Sheng Xu
Affiliation:
Center for Interventional Oncology, Radiology and Imaging Sciences, NIH Clinical Center, National Institute of Biomedical Imaging and Bioengineering, and National Cancer Institute Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA
Bradford J. Wood
Affiliation:
Center for Interventional Oncology, Radiology and Imaging Sciences, NIH Clinical Center, National Institute of Biomedical Imaging and Bioengineering, and National Cancer Institute Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA
Hongliang Ren
Affiliation:
Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore
Zion Tsz Ho Tse*
Affiliation:
Department of Electronic Engineering, University of York, Heslington, York, UK
*
Author for correspondence: Zion Tsz Ho Tse, Department of Electronic Engineering, University of York, Heslington, York, UK. E-mail: [email protected]
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Abstract

Radiofrequency ablation (RFA) is a non-invasive image-guided procedure where tumors are heated in the body with electrical current. RFA procedures are commonly indicated for patients with limited local disease or who are not surgical candidates. Current methods of RFA use multiple cords and wires that ergonomically complicate the procedure and present the risk of cutting or shorting the circuit if they are damaged. A wireless RFA technique based on electromagnetic induction is presented in this paper. The transmitting and receiving coils were coupled to resonate at the same frequency to ensure the highest power output. The receiving coil was connected to two insulated electrodes on a catheter, which allowed the current to flow to the targeted tissue. The prototype system was tested with ex-vivo bovine tissue, which has similar thermal and electrical properties to human tissue. The setup can monitor the received power, efficiency, temperature, and ablation zone during ablation procedures. The maximum received power was 15 W, and the average maximum efficiency was 63.27%. The novel system was also able to ablate up to a 2 cm ablation zone in non-perfused tissue. This proof of concept for performing RFA wirelessly with electromagnetic induction may merit further optimization.

Keywords

Medical devicesradiofrequency ablationtissue ablationwireless power transfer
Type
Research Article
Information
Wireless Power Transfer , Volume 7 , Issue 2 , September 2020 , pp. 95 - 105
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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References

Ren, H, Campos-Nanez, E, Yaniv, Z, Banovac, F, Abeledo, H, Hata, N and Cleary, K (2013) Treatment planning and image guidance for radiofrequency ablations of large tumors. IEEE Journal of Biomedical and Health Informatics 18(3), 920–928.Google ScholarPubMed
Blessing, E, Esler, MD, Francis, DP and Schmieder, RE (2013) Cardiac ablation and renal denervation systems have distinct purposes and different technical requirements. JACC: Cardiovascular Interventions 6(3), 314.Google ScholarPubMed
Pandina, GJ, Lindenmayer, JP and Lull, J and Lim, P and Gopal, S and Herben, V and Kusumakar, V and Yuen, E and Palumbo, J (2012) A randomized, placebo-controlled study to assess the efficacy and safety of 3 doses of paliperidone palmitate in adults with acutely exacerbated schizophrenia. Journal of Clinical Psychopharmacology 30(3), 235–244.CrossRefGoogle Scholar
Joo, Y-C, Park, J-Y and Kim, K-H (2013) Comparison of alcohol ablation with repeated thermal radiofrequency ablation in medial branch neurotomy for the treatment of recurrent thoracolumbar facet joint pain. Journal of Anesthesia 27(3), 390–395.CrossRefGoogle ScholarPubMed
Livraghi, T, Goldberg, SN, Lazzaroni, S, Meloni, F, Solbiati, L and Gazelle, GSJR (1999) Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 210(3), 655–661.Google ScholarPubMed
Pearson, AS, Izzo, F, Fleming, RD, Ellis, LM, Delrio, P, Roh, MS, Granchi, J and Curley, SA (1999) Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. The American Journal of Surgery 178(6), 592–598.CrossRefGoogle ScholarPubMed
Souchon, R, Rouvière, O, Gelet, A, Detti, V, Srinivasan, S, Ophir, J and Chapelon, JY (2003) Visualisation of HIFU lesions using elastography of the human prostate in vivo: preliminary results. Ultrasound in Medicine and Biology 29(7), 1007–1015.CrossRefGoogle ScholarPubMed
Vogel, A and Venugopalan, VJCR (2003) Mechanisms of pulsed laser ablation of biological tissues. Chemical Reviews 103(2), 577–644.CrossRefGoogle Scholar
Brace, CL (2009) Radiofrequency and microwave ablation of the liver, lung, kidney, and bone: what are the differences? Current Problems in Diagnostic Radiology 38(3), 135–143.Google ScholarPubMed
Curley, SA (2003) Radiofrequency ablation of malignant liver tumors. Annals of Surgical Oncology 10(4), 338–347.CrossRefGoogle Scholar
Mirza, AN, Fornage, BD, Sneige, N, Kuerer, HM, Newman, LA, Ames, FC and Singletary, SE (2001) Radiofrequency ablation of solid tumors. Cancer Journal (Sudbury, Mass.) 7(2), 95–102.Google ScholarPubMed
Goldberg, SN, Gazelle, GS, Solbiati, L, Rittman, WJ and Mueller, PR (1996) Radiofrequency tissue ablation: increased lesion diameter with a perfusion electrode. Academic Radiology 3(8), 636–644.CrossRefGoogle ScholarPubMed
Haines, DE (1993) The biophysics of radiofrequency catheter ablation in the heart: the importance of temperature monitoring. Pacing and Clinical Electrophysiology 16(3), 586–591.CrossRefGoogle ScholarPubMed
Moore, J, Nilsson, KR, Wood, B, Xu, S and Tse, ZTH (2018) Liver radiofrequency ablation using wirelessly powered catheter and generator. in 2018 IEEE PELS Workshop on Emerging Technologies: Wireless Power Transfer, Wow 2018, Montreal, Canada, July 2018: Institute of Electrical and Electronics Engineers Inc.CrossRefGoogle Scholar
Haemmerich, D (2010) Biophysics of radiofrequency ablation. Critical Reviews in Biomedical Engineering 38(1), 1–16.CrossRefGoogle ScholarPubMed
Morimoto, T, Kimura, S, Konishi, Y, Komaki, K, Uyama, T, Monden, Y, Kinouchi, DY and Iritani, DT (1993) A study of the electrical Bio-impedance of tumors. Journal of Investigative Surgery 6(1), 25–32.CrossRefGoogle ScholarPubMed
Haemmerich, D (2010) Mathematical modeling of impedance controlled radiofrequency tumor ablation and ex-vivo validation. in Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE, IEEE, pp. 1605–1608.CrossRefGoogle Scholar
Haemmerich, D, Staelin, T, Tungjitkusolmun, S, Lee, FT, Mahvi, DM and Webster, JG (2001) Hepatic bipolar radio-frequency ablation between separated multiprong electrodes. IEEE Transactions on Biomedical Engineering 48(10), 1145–1152.CrossRefGoogle ScholarPubMed
Nakada, SY, Jerde, TJ, Warner, TF, Wright, AS, Haemmerich, D, Mahvi, DM and Lee, FT Jr. (2003) Bipolar radiofrequency ablation of the kidney: comparison with monopolar radiofrequency ablation. Journal of Endourology 17(10), 927–933.CrossRefGoogle Scholar
Decadt, B and Siriwardena, AK (2004) Radiofrequency ablation of liver tumours: systematic review. The Lancet Oncology 5(9), 550–560.CrossRefGoogle ScholarPubMed
McGahan, JP and Dodd, G III (2001) Radiofrequency ablation of the liver: current status. American Journal of Roentgenology 176(1), 3–16.CrossRefGoogle Scholar
Boeti, MPS, Grigorie, RZ and Popescu, I (2013) Laparoscopic radiofrequency ablation of liver tumors. Hepatic Surgery. Available at https://www.intechopen.com/books/hepatic-surgery/laparoscopic-radiofrequency-ablation-of-liver-tumors.CrossRefGoogle Scholar
Machi, J, Uchida, S, Sumida, K, Limm, WM, Hundahl, SA, Oishi, AJ, Furumoto, NL and Oishi, RH (2001) Ultrasound-guided radiofrequency thermal ablation of liver tumors: percutaneous, laparoscopic, and open surgical approaches. Journal of Gastrointestinal Surgery 5(5), 477–489.CrossRefGoogle ScholarPubMed
Simon, CJ, Dupuy, DE and Mayo-Smith, WW (2005) Microwave ablation: principles and applications. Radiographics 25(suppl_1), S69–S83.CrossRefGoogle Scholar
Meloni, MF, Chiang, J, Laeseke, PF, Dietrich, CF, Sannino, A, Solbiati, M, Nocerino, E, Brace, CL and Lee, FT Jr. (2017) Microwave ablation in primary and secondary liver tumours: technical and clinical approaches. International Journal of Hyperthermia 33(1), 15–24.CrossRefGoogle ScholarPubMed
Hoffmann, R, Rempp, H, Keßler, DE, Weiß, J, Pereira, PL, Nikolaou, K and Clasen, S (2017) MR-guided microwave ablation in hepatic tumours: initial results in clinical routine. European Radiology 27(4), 1467–1476.CrossRefGoogle Scholar
Lachenmayer, A, Tinguely, P, Maurer, MH, Frehner, L, Knöpfli, M, Peterhans, M, Weber, S, Dufour, JF, Candinas, D and Banz, V (2019) Stereotactic image-guided microwave ablation of hepatocellular carcinoma using a computer-assisted navigation system. Liver International 39(10), 1975–1985.CrossRefGoogle ScholarPubMed
Dou, J-P, Liang, P and Yu, J (2016) Microwave ablation for liver tumors. Abdominal Radiology 41(4), 650–658.CrossRefGoogle ScholarPubMed
Sidoff, L and Dupuy, DE (2017) Clinical experiences with microwave thermal ablation of lung malignancies. International Journal of Hyperthermia 33(1), 25–33.CrossRefGoogle ScholarPubMed
Wu, X, Liu, B and Xu, B (2016) Theoretical evaluation of high frequency microwave ablation applied in cancer therapy. Applied Thermal Engineering 107, 501–507.CrossRefGoogle Scholar
Agbinya, JI (2015) Wireless Power Transfer. Gistrup, Denmark: River Publishers.Google Scholar
Kim, KY (2012) Wireless power transfer-principles and engineering explorations.CrossRefGoogle Scholar
Stielau, OH and Covic, GA (2000) Design of loosely coupled inductive power transfer systems. in PowerCon 2000. 2000 International Conference on Power System Technology. Proceedings (Cat. No. 00EX409), vol. 1: IEEE, pp. 85–90.CrossRefGoogle Scholar
William, BT (1995) Advanced Electromagnetism: Foundations: Theory and Applications. New Jersey, USA: World Scientific Publishing Co., Inc.Google Scholar
Costanzo, A, Dionigi, M, Mastri, F and Mongiardo, M (2013) Rigorous modeling of mid-range wireless power transfer systems based on Royer oscillators. in 2013 IEEE Wireless Power Transfer (WPT), IEEE, pp. 69–72.CrossRefGoogle Scholar
Mastri, F, Costanzo, A, Dionigi, M and Mongiardo, M (2012) Harmonic balance design of wireless resonant-type power transfer links. in 2012 IEEE MTT-S International Microwave Workshop Series on Innovative Wireless Power Transmission: Technologies, Systems, and Applications, IEEE, pp. 245–248.CrossRefGoogle Scholar
Kovoor, P, Daly, M, Pouliopoulos, J, Dewsnap, MB, Eipper, V and Ross, DL (2005) Effect of inter-electrode distance on bipolar intramural radiofrequency ablation. Pacing and Clinical Electrophysiology 28(6), 514–520.CrossRefGoogle ScholarPubMed
DeltaTrak. “FlashCheck® Jumbo Display Auto-Cal Needle Probe Thermometer.” DeltaTrak. Available at https://www.deltatrak.com/digital-min-max-thermometers/11063-flashcheck-jumbo-display-auto-cal-needle-probe-thermometer (accessed 4-3-2020, 2020).Google Scholar
Council, NR (1996) Mathematics and Physics of Emerging Biomedical Imaging. Washington, D.C: National Academies Press.Google Scholar