Studies were conducted in 1999, 2000, and 2001 to evaluate broadleaf weed control in cotton from POST applications of trifloxysulfuron plus pyrithiobac. Trifloxysulfuron was applied at 2.5, 5, and 7.5 g ai/ha, and pyrithiobac was applied at 0, 17, and 35 g ai/ha in a factorial treatment arrangement. Cotton injury was affected by rates of both herbicides at 7 and 14 d after treatment (DAT) with injury ranging from 19 to 26%. Broadleaf weed control at 28 DAT from mixtures of the herbicides was generally commercially acceptable. Combinations of 17 or 35 g/ha pyrithiobac plus trifloxysulfuron controlled common ragweed, velvetleaf, common lambsquarters, annual morningglory species (ivyleaf morningglory, pitted morningglory, and tall morningglory), common cocklebur, spurred anoda, and jimsonweed at least 73% at 28 DAT. Trifloxysulfuron applied alone failed to control velvetleaf, spurred anoda, and jimsonweed. Cotton yield reflected weed control and yields increased with pyrithiobac rates. It is concluded that the spectra of the weeds controlled by trifloxysulfuron and pyrithiobac were highly complementary in these studies.

Greenhouse and laboratory experiments were conducted to investigate the response of common lambsquarters to POST applications of halosulfuron–methyl plus 2,4-D admixtures and to investigate the effects of 2,4-D on the absorption, translocation, and metabolism of halosulfuron. In the greenhouse, halosulfuron at 0, 4.5, 9, 18, and 36 g ai/ha was applied alone and mixed with 2,4-D at 0, 17, 35, and 70 g ai/ha POST to 7.5- to 9-cm seedlings, and plant fresh weights were determined 4 wk after treatment (WAT). Halosulfuron alone did not control this weed, while fresh weights of common lambsquarters treated with 2,4-D declined hyperbolically as rates increased. A synergistic response for mixtures of these herbicides occurred, as observed fresh weights for all combinations were less than expected based on independent action and the calibrated marginal responses. In the laboratory, 7.5- to 9-cm seedlings were treated POST with commercially formulated halosulfuron at 9 and 18 g/ha and 2,4-D at 0, 70, and 140 g/ha, respectively, followed by foliar-applied 14C-halosulfuron. Absorption of 14C-halosulfuron increased with time, and absorption and translocation were not influenced by the addition of 2,4-D. Results from these studies inferred that halosulfuron and 2,4-D were generally synergistic on common lambsquarters and that mechanisms other than absorption, translocation, and metabolism may explain this response.

Research was conducted to determine the minimum number of between-row mowings necessary to control annual weeds, chiefly giant foxtail and common waterhemp, without corn yield loss. Over 2 yr in Missouri, the between-row mowing systems that were evaluated consisted of a 38-cm band of PRE atrazine plus metolachlor at 2.2 plus 2.2 kg ai/ha applied over corn grown in 76-cm rows shortly after planting followed by one, two, or three between-row mowings close to the soil surface. Based on rated total weed control, between-row total weed cover, and corn yield, the weed-free check was statistically indistinguishable from a treatment in which banded PRE herbicide was followed by only one between-row mowing, late, when weeds were relatively large. When mowed once at 52 to 64 days after planting (DAP), giant foxtail and common waterhemp were greater than 85 cm tall. The yield was not increased by mowing earlier or more than once.

The “micro-rate” application, a POST combination of desmedipham plus phenmedipham at 0.045 + 0.045 kg ai/ha (desphen) or desmedipham plus phenmedipham plus ethofumesate (1:1: 1 ratio) (desphenetho) at 0.09 kg ai/ha plus triflusulfuron at 0.004 kg ai/ha plus clopyralid at 0.026 kg ae/ha plus 1.5% methylated seed oil received registration in 1998 and 2000 in North Dakota and Michigan, respectively. Herbicide rates are reduced by 80%, compared to standard-split applications, and growers typically apply the micro-rate three to five times to very small weeds that are 1 cm or less in height. In standard-split applications, growers make two sequential applications, the first when weeds are 1.5 cm tall and the sequential application usually 10 to 14 d later. Research was conducted in small plots and large grower plots in 2001 and 2002 to determine the effect of PRE herbicides on weed control and sugarbeet injury from micro-rates compared to standard-split POST herbicide applications. Sugarbeet populations were reduced in the cycloate treatment compared to all other PRE and the no-PRE treatment in 2001 and in the S-metolachlor compared to the ethofumesate treatment in 2002. Sugarbeet injury was 6% or less from POST-only treatments in 2001. Control of common lambsquarters and Amaranthus spp. by desphen and desphenetho treatments was similar. Sugarbeet injury in 2002 was 29 to 43% from POST-only treatments. The standard-split of desphenetho was more injurious than the standard-split of desphen. Common lambsquarters control was greater in both the standard-split and micro-rate of desphenetho compared to the standard-split of desphen in 2002. However, sugarbeet populations and recoverable white sucrose per hectare did not differ among POST herbicide treatments in either year. No herbicide program provided 100% control of all weeds in both years. In the seven large production fields, PRE herbicide treatments did not reduce sugarbeet populations or recoverable sucrose per hectare compared to the no-PRE control. Weed control from four POST micro-rate applications only was similar to weed control in instances in which PRE herbicides were applied prior to the POST micro-rate applications.

Trials were conducted under weed-free conditions in 2001, 2002, and 2003 on a loamy sand soil in Georgia to investigate the phytotoxicity of flumioxazin on peanut, and in separate trials, the effects on peanut maturity. The first study evaluated time of flumioxazin application (0, 2, 4, 6, 8, and 10 d after planting [DAP]) and flumioxazin rate (nontreated, 71, and 105 g ai/ha). Peanut (variety ‘C99R’) were seeded 3.2 cm deep and irrigated immediately after seeding. Flumioxazin applied to peanut 6, 8, and 10 DAP significantly injured peanut (20 to 59%) early season, with more phytotoxicity from flumioxazin at 105 g/ha than 71 g/ha. However, peanut stand was not reduced by any of the times of application or rates. Peanut recovered by midseason, except in cases of severe (up to 49%) visual phytotoxic injury. Peanut yields were not affected by either flumioxazin application timing or rate. The second study (variety ‘Georgia Green’) evaluated flumioxazin applied at 105 g/ha at varying intervals after planting to determine the phytotoxic effects on peanut maturity using the hull-scrape method. Peanut maturity was delayed by flumioxazin when applied 1 d after planting and later. These results show that the optimum time of application is from immediately after planting to 2 d after planting, but ideally, the application should be made immediately after planting. The highest recommended flumioxazin rate, 105 g/ha, is not significantly phytotoxic when applied within the recommended range of timings and has no effect on yield. However, there is potential for yield loss as peanut maturity is delayed in cases of severe injury.

Greenhouse and field experiments were conducted near Knoxville, TN, during 2002 and 2003 to investigate the effects of calcium and magnesium ions on the performance of three glyphosate formulations with and without diammonium sulfate (AMS). Weed species investigated in the greenhouse were broadleaf signalgrass, pitted morningglory, Palmer amaranth, and yellow nutsedge. Three glyphosate formulations (isopropylamine salt, diammonium salt, and potassium salt) and two glyphosate application rates (0.42 and 0.84 kg ae/ha) were applied to weeds in water fortified with either calcium or magnesium at concentrations of 0, 250, 500, 750, and 1,000 ppm. In all comparisons, there were no differences in the three glyphosate formulations. Glyphosate activity was reduced only when cation concentration was >250 ppm, and this antagonism was not observed when 2% w/ w AMS was added to the spray solution. A chemical analysis of the calcium and magnesium concentrations in water collected from farmers indicated that water samples from eight different producers contained relatively low amounts of cations, with calcium at <40 ppm and magnesium at <8 ppm. In the field results using these and other waters as the herbicide carrier, broadleaf signalgrass control was greater with the 0.84 kg ae/ha than 0.42 kg ae/ha glyphosate rate regardless of water source or addition of AMS. Pitted morningglory responded similarly to glyphosate with water from all farms and with AMS added, and the addition of AMS gave similar results for both glyphosate rates. In 2003, common cocklebur was evaluated and control was >93% regardless of glyphosate rate, water source, or AMS addition. Based on these results, the addition of AMS-based adjuvants to many glyphosate applications may not be warranted.

Herbicide-resistant corn hybrids offer additional options for POST weed control in corn, and growers may benefit from information on the consistency of these weed-control strategies. Studies were conducted in Indiana, Illinois, Michigan, and Ohio, in 2000 and 2001, to evaluate weed control among herbicide strategies for imidazolinone-resistant, glufosinate-resistant, glyphosate-resistant, and conventional corn. Isogenic hybrids were utilized to minimize variation in growth and yield potential among hybrids. The glyphosate-resistant corn postemergence (glyphosate-POST) treatment provided more consistent control of giant foxtail than the PRE, conventional corn postemergence (conventional-POST), glufosinate-resistant corn postemergence (glufosinate-POST), and imidazolinone-resistant corn postemergence (imi-POST) treatments. All four POST treatments were more consistent and provided greater control than the PRE treatment of the large-seeded broadleaf weeds velvetleaf, giant ragweed, common cocklebur, and morningglory species. Conventional-POST and imi-POST were more consistent than glufosinate-POST and glyphosate-POST treatments in controlling giant ragweed. There were no statistical differences in the variability of PRE or POST treatments for control of common lambsquarters, common ragweed, and redroot pigweed. Corn yield varied among locations and years. The glyphosate-POST treatment did not reduce yield relative to the weed-free treatment, the imi-POST and glufosinate-POST treatments each reduced yield in one of eight locations, and the conventional-POST treatment reduced yield in three of eight locations.

Greenhouse studies were conducted to determine the effect of 1-aminomethanamide dihydrogen tetraoxosulfate (AMADS) as a spray adjuvant on the efficacy of three different glyphosate formulations, the isopropylamine salt (glyphosate-IPA), potassium salt (glyphosate-K), and the acid of glyphosate dissolved in AMADS (glyphosate-A). All formulations were tested at multiple rates with and without AMADS (2% v/v) on greenhouse-grown corn, and growth inhibition was determined by measuring the elongation of the newest emerging leaf between 1 and 7 d after treatment. AMADS increased the efficacy of all three glyphosate formulations by threefold to fourfold. The IC50 values for glyphosate-IPA, glyphosate-K, and glyphosate-A without AMADS on corn were 77, 54, and 53 g ae/ha, respectively; and with AMADS the values were 20, 18, and 21 g/ha, respectively. AMADS was more effective than ammonium sulfate (2% w/v) in overcoming the antagonism of hard water (200 parts per million Ca+2) on glyphosate-K efficacy on corn. The rainfastness of glyphosate-IPA, glyphosate-A, and glyphosate-K was improved with AMADS.

There is a high potential for inadvertent herbicide injury to crops in western Canada on an annual basis because of the diversity of crops grown in close proximity to each other, although accurate data regarding the annual number of injury incidents is not available. A field study was conducted at two locations in southern Manitoba, Canada, in 2001 and 2002, to investigate the effects of a range of dosages of MCPA ester, glyphosate, and thifensulfuron:tribenuron (2:1) applied to the seedling growth stage of conventional (nongenetically engineered) canola and white bean on subsequent shoot dry matter and crop yield. Similar to other studies that utilized sublethal herbicide dosages, results between site-years were variable, particularly for crop yield. Where possible, a nonlinear log-logistic model was fitted to the data. Generally, canola was more sensitive than white bean to the herbicides used in this study. Based on the fitted regression equations and recorded mean values for canola, 10% of the commercial herbicide dosage normally applied in other (possibly adjacent) crops caused greater than 10% canola yield loss for 9 of 12 unique combinations of herbicide-site-year. For white bean, 10% of the commercial herbicide dosage caused yield losses greater than 10% for only 4 of 13 unique combinations of herbicide-site-year. Spray drift is probably the most common source of inadvertent application of herbicide to sensitive crops; generally, only a fraction of the herbicide dosage applied on an adjacent crop drifts off-target. The results of this study indicate that for any of the three herbicides investigated on canola and white bean, it is difficult to accurately predict eventual crop yield loss based on early season sublethal herbicide injury symptoms due to site-year variability and the potential for crop recovery and compensatory growth. This response was particularly true for white bean in this study.

A 3-yr dryland study was initiated in 1999 at Munday, TX, on an Altus fine sandy loam to determine the most appropriate cotton growth stage or stages at which to apply glyphosate. The objectives were: (1) to evaluate control of silverleaf nightshade in the cotton and (2) to determine the effect on yield. Treatments were: (1) control (C; two cultivations), (2) early glyphosate at the four-leaf stage (E), (3) early glyphosate followed by a midseason application 21 d later (E+M), (4) two cultivations plus late glyphosate at 20% open bolls (L), (5) treatment E+L, and (6) treatment E+M+L. In fall 1999 and 2001, silverleaf nightshade stem numbers decreased in the plots sprayed early and midseason, and increased in plots receiving only late or no applications when compared with the counts in the spring of those years. However, in fall 2000, nightshade numbers were less than in early spring 2000 regardless of treatment, probably because of hot and dry weather. In fall 2001, silverleaf nightshade populations had increased 13-fold and twofold for the C and L treatments, respectively, when compared with populations at the beginning of the study. Other treatments had population decreases of 10 to 90%. Three-year average lint yields were higher with early or early plus midseason applications. Lint yields were similar with early or early plus midseason sprays. Lint yields were higher when nightshade/cotton biomass competition was lower. Early application of glyphosate can effectively control silverleaf nightshade populations and can increase yield when compared to no application or a late application.

The effects of spring tillage sequence on summer annual weed populations were evaluated over two cycles of a 3-yr crop rotation of snap beans, sweet corn, and winter wheat. Continuous no-till (N) planting of vegetable crops each spring (NNNN) reduced summer annual weed density 63 to 86% compared to that of continuous conventional tillage (CCCC), depending upon site and herbicide level. Hairy nightshade populations were reduced by 88 to 96% when spring tillage was eliminated from the crop rotation. The effects of the NNNN spring tillage sequence on weed density were similar at two sites even though the crop rotations at the two sites began with different crops. The rotational tillage sequence of NCNC at the East site, in a crop rotation that began with corn, reduced summer annual weed density by 46 to 51% compared to that of continuous conventional tillage and planting (CCCC) at low and medium herbicide rates, respectively. In contrast, the tillage sequence of CNCN in the same crop rotation and at the same site increased weed density by 80% compared to that of CCCC at a low herbicide rate. The effects of the NCNC and CNCN rotational tillage sequences on weed density were reversed at the West site, and was probably caused by pairing sweet corn with conventional tillage rather than no tillage. The reduction in summer annual weed density caused by reduced spring tillage frequency did not significantly increase crop yields.

Three field experiments were conducted to evaluate efficacy of BAS 625, cyhalofop, and fenoxaprop plus isoxadifen when applied alone or with acifluorfen plus bentazon, acifluorfen, bentazon, triclopyr, bensulfuron, halosulfuron, carfentrazone, and propanil. Broadleaf signalgrass control with fenoxaprop plus isoxadifen was reduced by triclopyr and halosufuron. None of these herbicides reduced Amazon sprangletop control by fenoxaprop plus isoxadifen. Barnyardgrass control with fenoxaprop plus isoxadifen was reduced by halosulfuron and propanil. Barnyardgrass and Amazon sprangletop control by cyhalofop was reduced by bentazon plus acifluorfen, bentazon, acifluorfen, triclopyr, bensulfuron, or halosulfuron. Broadleaf signalgrass control with cyhalofop was reduced by triclopyr and halosulfuron. Amazon sprangletop control by cyhalofop was reduced by all herbicides. Barnyardgrass control with BAS 625 was reduced when applied with propanil, bentazon, or bentazon plus acifluorfen. Broadleaf signalgrass control with BAS 625 was reduced when applied with bentazon plus acifluorfen. Amazon sprangletop control with BAS 625 was reduced when applied with bentazon, acifluorfen, halosulfuron, or propanil.

Field experiments were conducted at three locations in 2003 and 2004 to examine clethodim and quizalofop-P efficacy on spring wheat seedlings when applied alone or in tank mixtures with herbicides used to control broadleaf weeds. Clethodim at the recommended rate of 30 g/ha reduced spring wheat biomass by 63 to 98% and was only >90% in three of six site years. In contrast, quizalofop-P at the recommended rate of 36 g/ha reduced wheat biomass >90% in all cases. Clethodim or quizalofop-P could be tank mixed with 2,4-D ester, bromoxynil, or bromoxynil plus MCPA ester with little risk of reduced efficacy on wheat. However, 2,4-D amine was highly antagonistic to both herbicides. The commercial mixture of thifensulfuron plus tribenuron reduced clethodim, but not quizalofop-P, efficacy on wheat. Herbicide options exist for simultaneous control of volunteer glyphosate-resistant canola and glyphosate-resistant wheat if the latter technology were to be commercialized in the future.

Field studies were conducted to determine the effect of season-long interference of smooth pigweed or livid amaranth on the shoot dry weight and fruit yield of cucumber. Smooth pigweed or livid amaranth densities as low as 1 to 2 weeds per m2 caused a 10% yield reduction in cucumber. The biological threshold of smooth pigweed or livid amaranth with cucumber is between 6 to 8 weeds per m2. Consequently, weed interference resulted in a reduction in cucumber fruit yield. Smooth pigweed, livid amaranth, and cucumber plant dry weight decreased as weed density increased. Evaluation of smooth pigweed, livid amaranth, and cucumber mean dry weights in interspecific competition studies indicated that cucumber reduced the dry weight of both species of amaranths.

Five studies were conducted at Clayton, Rocky Mount, and Lewiston-Woodville, NC, in 2001 and 2002, to evaluate weed management, crop tolerance, and yield in strip- and conventional-tillage glyphosate-resistant cotton. Cotton was treated with two glyphosate formulations; glyphosate-IP (isopropylamine salt) or glyphosate-TM (trimethylsulfonium salt), early postemergence (EPOST) alone or in a mixture with S-metolachlor. Early season cotton injury was minimal (3%) with either glyphosate formulation alone or in mixture with S-metolachlor. Weed control and cotton yields were similar for both glyphosate formulations. The addition of S-metolachlor to either glyphosate formulation increased control of broadleaf signalgrass, goosegrass, large crabgrass, and yellow foxtail 14 to 43 percentage points compared with control by glyphosate alone. S-metolachlor was not beneficial for late-season control of entireleaf morningglory, jimsonweed, pitted morningglory, or yellow nutsedge. The addition of S-metolachlor to either glyphosate formulation increased control of common lambsquarters, common ragweed, Palmer amaranth, smooth pigweed, and velvetleaf 6 to 46 percentage points. The addition of a late postemergence-directed (LAYBY) treatment of prometryn plus MSMA increased control to greater than 95% for all weed species regardless of EPOST treatment, and control was similar with or without S-metolachlor EPOST. Cotton lint yield was increased 220 kg/ha with the addition of S-metolachlor to either glyphosate formulation compared with yield from glyphosate alone. The addition of the LAYBY treatment increased yields 250 and 380 kg/ha for glyphosate plus S-metolachlor and glyphosate systems, respectively. S-metolachlor residual activity allowed for an extended window for more effective LAYBY application to smaller weed seedlings instead of weeds that were possibly larger and harder to control.

Roots of Canada thistle were excavated from the soil monthly from 1999 to 2001 near Scottsbluff, NE, to quantify the influence of changing soil temperature on free sugars and fructans in roots. Sucrose concentrations were low from May through August then increased in the fall and remained at high levels during winter and then declined in April as plants initiated spring growth. Changes in sucrose, 1-kestose (DP 3) and 1-nystose (DP 4) were shown to be closely associated with changes in soil temperature. During the second year of the study, average soil temperatures during the winter were colder than the first year and resulted in an increase of sucrose in Canada thistle roots. Experiments were conducted from 2001 to 2004 to determine whether there was a correlation between herbicide efficacy, time of herbicide application, and the resulting herbicide effect on root carbohydrate and Canada thistle control. Clopyralid applied in the fall reduced Canada thistle density 92% 8 months after treatment (MAT) whereas treatment made in the spring reduced plant density 33% 11 MAT. Fall application of clopyralid increased the activity of fructan 1-exohydrolase (1-FEH) in roots and was associated with a decline in sucrose, DP 4, and 1-fructofuranosyl-nystose (DP 5) 35 d after treatment (DAT). Spring application of clopyralid also resulted in a decrease of the same carbohydrates 35 DAT, but by 98 DAT, or early October, sucrose level in roots had recovered and was similar to nontreated plants. Fall application of 2,4-D or clopyralid reduced Canada thistle density 39 and 92% respectively, 8 MAT, but only clopyralid resulted in a reduction of sucrose, DP 4, DP 5, and total sugar and an increase of 1-FEH compared with nontreated plants.

Field research was conducted for 3 yr to evaluate crop response and weed control under conventional and reduced tillage in drill- and water-seeded imidazolinone-tolerant (IT) rice culture. Imazethapyr was applied at 70 g ai/ha PRE followed by (fb) imazethapyr at 70 g/ha applied POST to three- to four-leaf rice or at 105 g/ha PRE fb 70 g/ha POST. In both conventional and reduced tillage systems, imazethapyr applied PRE fb POST at 70 g ai/ha controlled red rice, barnyardgrass, Amazon sprangletop, and rice flatsedge 87 to 99% 35 d after POST treatment (DAT). At 35 DAT, Indian jointvetch control with sequential applications of imazethapyr was as high as 70% in water-seeded rice but no more than 54% in drill-seeded rice. Tillage, seeding method, and imazethapyr rate had no effect on days to 50% heading, seeds per panicle, seed weight per panicle, or percentage of seed harvest. However, a reduction of 27% in days to 50% heading, 80% in seeds per panicle, 84% in seed weight per panicle, and 100% in percentage seed harvest index occurred when imazethapyr was not applied because of weed interference. Culm number was reduced 28%, and culm weight 32% under reduced tillage compared with conventional tillage. With sequential applications of imazethapyr at 70 g/ha, rice yield was 63% greater when rice was water-seeded compared with drill-seeded. No differences in tillage systems for weed control, days to 50% heading, seed number, seed weight per panicle, percent seed, panicle height, lodging, or yield were observed. Results of these experiments demonstrate imazethapyr will effectively control weeds in both water- and drill-seeded rice and that reduced tillage can be used without negatively affecting rice production.

The suitability of a bioherbicide as a component of an integrated weed management program not only relies on its field efficacy, but also on its compatibility with other pest control measures that may be employed during the cropping season. The effects of selected pesticides applied according to label rates on Dactylaria higginsii, a biological control agent for purple nutsedge, were determined using mycelial growth on pesticide-amended potato dextrose agar (PDA) and conidial germination as indicators of pesticide sensitivity. Among the pesticides tested, the herbicides oxyfluorfen and sethoxydim and the fungicides fosetyl-Al and thiophanate methyl inhibited D. higginsii mycelial growth and reduced or completely inhibited conidial germination; the herbicide diuron, the fungicides metalaxyl and copper hydroxide, and the insecticide cyromazine reduced mycelial growth but did not reduce conidial germination. The miticide dicofol reduced mycelial growth and completely inhibited conidial germination while the herbicide imazapyr had no adverse effect on either the mycelial growth or conidial germination of D. higginsii.

Volunteer corn in soybean can reduce yields, interfere with harvest, and cause unacceptable levels of contamination by its presence in the harvested soybean. In Ontario, soybean frequently follow corn in rotation. The use of glyphosate-resistant corn and soybean varieties has increased dramatically in Ontario. Field studies were conducted at two locations in southwestern Ontario to determine whether quizalofop-p-ethyl, clethodim, and fenoxaprop-p-ethyl can be tank mixed with glyphosate to provide effective control of volunteer glyphosate-resistant corn in glyphosate-resistant soybean. Soybean plots were overseeded with glyphosate-resistant corn and treatments consisting of glyphosate applied alone and tank mixed with full and reduced rates of each graminicide with and without a recommended surfactant. Tank mixing the graminicides and adjuvants with glyphosate did not affect glyphosate weed control or crop tolerance. Use of a recommended adjuvant significantly improved the effectiveness of the graminicides, particularly when reduced rates were applied. Quizalofop-p-ethyl was the most effective graminicide for controlling glyphosate-resistant volunteer corn, followed by clethodim and fenoxaprop-p-ethyl.

Photosystem II (PS II) inhibitors halt electron flow within the photosynthetic electron transport chain, thereby leading to increased oxidative stress. As a result, their addition to mesotrione, which inhibits carotenoid biosynthesis by inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), is complementary. Field and greenhouse experiments were conducted in 2002 and 2003 to investigate the joint action of POST mesotrione plus PS II inhibitor herbicide combinations. The joint action of mesotrione plus PS II inhibitors was investigated across five plant species, three PS II inhibitors, and two moisture environments to determine their influence on the joint action response. Rates of mesotrione evaluated ranged from 4.4 to 87.6 g ai/ha alone and in combination with reduced rates of atrazine, bromoxynil, and metribuzin. In the field, all combinations of mesotrione at 8.8, 17.5, and 35.0 g/ha plus atrazine, bromoxynil, or metribuzin were synergistic for necrosis 6 d after treatment (DAT) on sunflower. Addition of atrazine at 280 g/ha to mesotrione at 8.8 g/ha increased velvetleaf leaf necrosis by 18 to 47%. In the greenhouse, the addition of bromoxynil at 70 g/ha to mesotrione at 17.5 g/ha increased leaf necrosis by 23 to 34% and biomass reduction by 38 to 47%. Synergism on Palmer amaranth occurred similarly under both normal and dry moisture environments at application. Plant height at application was found to influence detection of synergism on the whole-plant level.