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The VEP thresholds for full-field stimuli in dark-adapted infants

Published online by Cambridge University Press:  02 June 2009

Ronald M. Hansen  and
Anne B. Fulton
Ronald M. Hansen
Affiliation:
Department of Ophthalmology, Children's Hospital & Harvard Medical School, 300 Longwood Avenue, Boston
Anne B. Fulton
Affiliation:
Department of Ophthalmology, Children's Hospital & Harvard Medical School, 300 Longwood Avenue, Boston
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Abstract

Dark-adapted adults' electroretinographic b−wave thresholds are —2 log units below a−wave thresholds and ~3 log units above the perceptual threshold, and their perceptual and the visually evoked cortical potential (VEP) thresholds are similar. Dark-adapted infants' scotopic a− and b−wave thresholds for full-field stimuli are both about 0.5 log units above those of adults, but their scotopic VEP thresholds for such stimuli have not been studied. We obtained scotopic VEP thresholds for brief, full-field stimuli from dark-adapted, infants and adults to consider the relationships of the cortical responses to the responses of more distal structures, namely the rod photoreceptors (scotopic a−wave) and ON-bipolars (scotopic b−wave). The median VEP threshold of infants is 0.5 log unit above that of adults. Thus, the relationships of a− and b−wave and VEP thresholds in infants are similar to those in adults. These results are consistent with rod cell immaturities being the primary determinant of the difference between infants' and adults' thresholds.

Keywords

Human developmentRodsScotopic thresholdsVisual evoked cortical potential (VEP)
Type
Research Articles
Information
Visual Neuroscience , Volume 12 , Issue 2 , March 1995 , pp. 223 - 228
Copyright
Copyright © Cambridge University Press 1995

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References

Adams, W.L., Arden, G.B. & Behrman, J. (1969). Response of thè human visual cortex following excitation of peripheral retinal rods. British Journal of Ophthalmology 53, 539–452.CrossRefGoogle ScholarPubMed
Apkarian, P., Mirmiran, M. & Tijssen, R. (1991). Effects of behavioral state on visual processing in neonates. Neuropediatricia 22, 85–93.CrossRefGoogle ScholarPubMed
Brindley, G.S. & Westheimer, G. (1965). The spatial properties of the human electroretinogram. Journal of Physiology (London) 179, 518–537.CrossRefGoogle ScholarPubMed
Brown, A.M. (1990). Development of visual sensitivity to light and color in human infants: A critical review. Vision Research 30, 1159–1188.CrossRefGoogle ScholarPubMed
Brown, A.M., Dobson, V. & Maier, J. (1987). Visual acuity of human infants at scotopic, mesopic, and photopic luminances. Vision Research 27, 1845–1858.CrossRefGoogle ScholarPubMed
Frishman, L.J., Reddy, M.G., Robson, J.G. & Du, L. (1994). A comparison of human ERG with the psychophysical threshold in a Ganzfeld: Dark-adapted responses and effects of background light. Vision Science and Its Applications, Optical Society of America, 1994 Technical Digest Series 2, 276–279.Google Scholar
Fulton, A.B. & Hansen, R.M. (1992). The rod sensitivity of darkadapted human infants. Current Eye Research 11, 1193–1198.CrossRefGoogle Scholar
Fulton, A.B. & Hansen, R.M. (1994). Testing the possibly blind child. In The Eye in Infancy, ed. Isenberg, S.J., (second edition), pp. 547–560. St. Louis: Mosby.Google Scholar
Fulton, A.B., Dodge, J., Hansen, R.M., Schremser, J.-L. & Williams, T.P. (1991). The quantity of rhodopsin in young human eyes. Current Eye Research 10, 977–982.CrossRefGoogle ScholarPubMed
Fulton, A.B., Hansen, R.M., Dorn, E. & Hendrickson, A.E. (1994). Development of structure and function of the primate retina. Proceedings for Child Vision Research, Lyon, France (in press).Google Scholar
Hansen, R.M. & Fulton, A.B. (1993). Development of scotopic retinal sensitivity. In Infant Vision: Basic and Clinical Research, ed. Simons, K., pp. 130–142. New York: Oxford.Google Scholar
Hansen, R.M., Petersen, R.A. & Fulton, A.B. (1993). Retinopathy of prematurity (ROP), even if mild, perturbs the development of scotopic thresholds. Investigative Ophthalmology and Visual Science (Suppl.) 34, 1446.Google Scholar
Hansen, R.M., Fulton, A.B. & Harris, S.J. (1986). Background adaptation in human infants. Vision Research 26, 771–779.CrossRefGoogle ScholarPubMed
Hendrickson, A.E. & Drucker, D. (1992). The development of parafoveal and mid-peripheral human retina. Behavioral Brain Research 49, 21–31.CrossRefGoogle ScholarPubMed
Kojima, M. & Zrenner, E. (1980). Determination of local thresholds in the visual field by recording the scotopic visually evoked cortical potential in man. Ophthalmic Research 12, 1–8.CrossRefGoogle Scholar
Packer, O., Hendrickson, A.E. & Curcio, C.A. (1990). Developmental redistribution of photoreceptors across the Macaca nemestrina (Pigtail Macaque) retina. Journal of Comparative Neurology 298, 472–493.CrossRefGoogle Scholar
Pugh, E.N. Jr, & Lamb, T.D. (1993). Amplification and kinetics of the activation steps in phototransduction. Biochemica et Biophysica Acta 1141, 111–149.CrossRefGoogle ScholarPubMed
Sieving, P.A. & Nino, C. (1988). Scotopic threshold response (STR) of the human electroretinogram. Investigative Ophthalmology and Visual Science 29, 1608–1614.Google ScholarPubMed
Stockton, R. & Slaughter, M.M. (1989). B-wave of the electroretinogram: A reflection of ON-bipolar cell activity. Journal of General Physiology 93, 101–122.CrossRefGoogle ScholarPubMed
Werner, J.S. (1982). Development of scotopic sensitivity and the absorption spectrum of the human ocular media. Journal of the Optical Society of America, 72, 247–258.CrossRefGoogle ScholarPubMed
Wooten, B.R. (1972). Photopicand scotopic contributions to the human visually evoked cortical potential. Vision Research 12, 1647–1660.CrossRefGoogle Scholar