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Volume 127 - August 1975

Contents

Page 6 of 9

Papers

  • A Statistical Review of Controlled Trials of Imipramine and Placebo in the Treatment of Depressive Illnesses

  • S. C. Rogers, P. M. Clay
  • Published online by Cambridge University Press:
    29 January 2018, pp. 599-603

  • A method of reviewing a series of clinical trials by extracting the basic data in the form of 2 × 2 tables and analysing these by Fisher's two-tailed Exact Test is described, and illustrated by published imipramine-placebo trials.

    The results suggest that the benefit of this drug in patients with endogenous depression who have not become institutionalized is indisputable, and that further drug-placebo trials in this condition are not justified.

    Two of the three trials of imipramine in neurotic depression gave results showing significant improvement.

    Possible explanations of the apparent failure of this drug in groups of patients with undifferentiated depression are discussed.

Addiction

Book Reviews

Papers

  • Intravenous Tranquillization with ECT

  • Joan Gomez, Peter Dally
  • Published online by Cambridge University Press:
    29 January 2018, pp. 604-608

  • Forty depressed in-patients for whom electro-convulsive therapy had been prescribed were rated before treatment on depression and anxiety scales. Side effects, post-operative agitation and retrograde memory impairment were assessed in each patient after each of several treatments. Results were compared when no tranquillizer was given and when either diazepam or haloperidol was administered intravenously immediately before the anaesthetic. It was found than when ECT was given without tranquillization, the incidence and severity of post-operative agitation and of side effects were significantly greater in those patients with a high level of anxiety before treatment. Both diazepam and haloperidol were found to be effective in subduing agitation and side effects in anxious, depressed patients, but with diazepam recovery time was longer.

Prison After-Care

Book Reviews

Child Care

Book Reviews

Addiction

Book Reviews

Therapeutic Methods

Book Reviews

Research Methods

Book Reviews

Papers

  • Subjective Side-Effects of ECT

  • Joan Gomez
  • Published online by Cambridge University Press:
    29 January 2018, pp. 609-611

  • The incidence of side-effects present 24 hours after electroconvulsive therapy was studied in 96 patients who between them received 500 treatments in a consecutive series. None of the side-effects occurred frequently: headache was experienced after 2·6 per cent and subjective memory impairment after 3 per cent of treatments. None of the unwanted effects held any serious physical threat. The aspect of ECT most disliked by the patients in this study, and mentioned by 16 per cent of them, was the fear of permanent memory upset.

Books Received

Anna Freud

Book Reviews

Book Reviews

Books Received

Textbook

Book Reviews

Books Received

Szasz

Book Reviews

Front matter

  • BJP volume 127 issue 1 Cover and Front matter

  • Published online by Cambridge University Press:
    29 January 2018, pp. f1-f2
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Correction

Bereavement

Book Reviews

Page 6 of 9