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Sulpiride and Haloperidol in Schizophrenia: A Double-blind Cross-over Study of Therapeutic Effect, Side Effects and Plasma Concentrations

Published online by Cambridge University Press:  29 January 2018

Jes Gerlach ,
Kirsten Behnke ,
Jon Heltberg ,
Ebbe Munk-Andersen  and
Henrik Nielsen
Jes Gerlach*
Affiliation:
Sct. Hans Hospital, Dept. AEH, 4000 Roskilde, Denmark
Kirsten Behnke
Affiliation:
Sct. Hans Hospital, Dept. AEH, 4000 Roskilde, Denmark
Jon Heltberg
Affiliation:
Sct. Hans Hospital, Dept. AEH, 4000 Roskilde, Denmark
Ebbe Munk-Andersen
Affiliation:
Sct. Hans Hospital, Dept. AEH, 4000 Roskilde, Denmark
Henrik Nielsen
Affiliation:
Sct. Hans Hospital, Dept. AEH, 4000 Roskilde, Denmark
*
∗Correspondence
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Summary

In a double-blind cross-over trial, 20 chronic schizophrenic patients were treated with sulpiride and haloperidol in two 12-week periods. The final median dose of sulpiride was 2000 mg/day (range 800–3200) and of haloperidol 12 mg/day (range 6–24). Sulpiride had an antipsychotic effect and therapeutic profile not significantly different from that of haloperidol. In spite of the high doses of sulpiride, extrapyramidal side-effects were seen less frequently during the first four weeks of the sulpiride period than during the corresponding haloperidol period (P < 0.05), whereas autonomic side-effects were equally rare for both drugs. A positive correlation was found between daily dose and plasma concentration of both sulpiride (P < 0.001) and haloperidol (P < 0.05), but no correlation could be established between clinical effects and plasma levels of either neuroleptic.

Type
Papers
Information
The British Journal of Psychiatry , Volume 147 , Issue 3 , September 1985 , pp. 283 - 288
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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