Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-30T19:07:52.623Z Has data issue: false hasContentIssue false

Side-effects of Antidepressants

Published online by Cambridge University Press:  06 August 2018

John Cookson*
Affiliation:
The Royal London Hospital, London

Extract

The adverse effects of antidepressants include their pharmacological side-effects, toxic effects, interactions with other drugs, and symptoms occurring during their withdrawal. The focus of this paper is on the pharmacological side-effects.

Type
Research Article
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baldwin, D., Fineberg, N. & Montgomery, S. (1991) Fluoxetine, fluvoxamine and extrapyramidal tract disorders. International Clinical Psychopharmacology, 6, 5158.CrossRefGoogle ScholarPubMed
Benfield, P. & Ward, A. (1986) Fluvoxamine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs, 32, 313334.CrossRefGoogle ScholarPubMed
Cohn, J. B. & Wilcox, C. (1985) Comparison of fluoxetine, imipramine and placebo in patients with major depressive disorder. Journal of Clinical Psychiatry, 46, 2631.Google Scholar
Cohn, J. B., Collins, G. A., Ashbrook, E., et al (1989) A comparison of fluoxetine, imipramine and placebo in patients with bipolar depressive disorder. International Clinical Psychopharmacology, 4, 313322.Google Scholar
Cooper, G. L. (1988) The safety of fluoxetine - an update. British Journal of Psychiatry, 153 (suppl. 3), 7786.Google Scholar
Committee On Safety Of Medicines (1988) Current Problems, 23.Google Scholar
Committee On Safety Of Medicines (1989) Current Problems, 26.Google Scholar
Davis, M. (1991) Hepatotoxicity of anti-depressants. International Clinical Psychopharmacology, 6, 97103.Google Scholar
Doogan, D. P. (1991) Toleration and safety of sertraline: experience world-wide. International Clinical Psychopharmacology, 6 (suppl. 2), 4756.Google Scholar
Dunbar, G. C., Cohn, J. B., Fabre, L. F., et al (1991) A comparison of paroxetine, imipramine and placebo in depressed outpatients. British Journal of Psychiatry, 159, 394398.Google Scholar
Feighner, J. P., Meredith, C. H., Dutt, J. E., et al (1982) A double-blind comparison of lofepramine, imipramine, and placebo in patients with primary depression. Acta Psychiatrica Scandinavica, 66, 100108.Google Scholar
Garvey, M. J. & Tollefson, G. D. (1986) Occurrence of myoclonus in patients with cyclic anti-depressants. Archives of General Psychiatry, 44, 269272.Google Scholar
Glassman, A. H., Roose, S. P., Giardin, E. V., et al (1981) Cardiovascular effects of tricyclic anti-depressants. In Psychopharmacology: the Third Generation of Progress (ed. Meltzer, H. Y.), pp. 14371442. New York: Raven Press.Google Scholar
Lejoyeux, M., Rouillon, F., Ades, J., et al (1992) Neural symptoms induced by tricyclic anti-depressants: phenomenology and pathophysiology. Acta Psychiatrica Scandinavica, 85, 249256.CrossRefGoogle ScholarPubMed
McCormick, S., Olin, J. & Brotman, A. W. (1990) Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients. Journal of Clinical Psychiatry, 51, 383384.Google Scholar
Modell, J. G. (1989) Repeated observations of yawning, clitoral enlargement, and orgasm associated with fluoxetine administration. Journal of Clinical Psychopharmacology, 9, 63.Google Scholar
Paykel, E. S., Mueller, P. S. & La Vergne, P. M. (1973) Appetite, weight gain and carbohydrate craving. British Journal of Psychiatry, 123, 501507.Google Scholar
Rickels, K., Amsterdam, J. D. & Avallone, M. F. (1986) Fluoxetine in major depression: a controlled study. Current Therapeutic Research, 30, 559563.Google Scholar
Stark, P. & Hardison, C. D. (1985) A review of multicentre controlled studies of fluoxetine vs imipramine and placebo in outpatients with major depressive disorder. Journal of Clinical Psychiatry, 148, 705713.Google Scholar
Sternbach, H. (1991) The serotonin syndrome. American Journal of Psychiatry, 148, 705713.Google ScholarPubMed
Versiani, M., Nardi, A. E., Figueira, I. L. V., et al (1990) Tolerability of moclobemide, a new reversible inhibitor of monoamine oxidase A, compared with other anti-depressants and placebo. Acta Psychiatrica Scandinavica (suppl. 360), 2428.Google Scholar
Wakelin, J. (1986) Fluvoxamine in the treatment of the older depressed patient: double-blind placebo controlled data. International Clinical Psychopharmacology, 1, 221230.CrossRefGoogle ScholarPubMed
Warner, M. D., Peabody, C. A., Whiteford, H. A., et al (1987) Trazodone and priapism. Journal of Clinical Psychiatry, 48, 244.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.