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Psychiatry and the New Magnetic Resonance Era

Published online by Cambridge University Press:  06 August 2018

T. Lock ,
Mohammed T. Abou-Saleh  and
Richard H. T. Edwards
T. Lock*
Affiliation:
Magnetic Resonance Research Centre, University of Liverpool
Mohammed T. Abou-Saleh
Affiliation:
Department of Psychiatry, University of Liverpool
Richard H. T. Edwards
Affiliation:
Magnetic Research Centre, University of Liverpool
*
∗Box 147, University of Liverpool, Liverpool L69 3BX
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Extract

Psychiatry's lack of understanding of the pathogenesis of mental disorders has resulted in the attempt, within the antipsychiatry movement, to persuade the world that mental disorder does not exist (Szasz, 1961). Progress towards understanding the underlying biological bases of psychiatric syndromes has been impeded by two factors: (a) a most effective physical barrier – the skull; and (b) dichotomous thinking of structure on the one hand and function on the other.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 157 , Issue S9: Brain imaging in psychiatry , December 1990 , pp. 38 - 55
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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References

Ackermann, J., Grove, T., Wong, G., et al (1980) Mapping of metabolism in whole animals by 31P NMR using surface coils. Nature, 283, 167–170.Google Scholar
Arndt, D. C., Ratner, A. V., Faull, K. F., et al (1988) 19F magnetic resonance imaging and spectroscopy of a fluorinated neuroleptic ligand: in-vivo and in-vitro studies. Psychiatry Research, 25, 73–79.Google Scholar
Arnold, D. L., Matthews, P. M., Francis, G., et al (1989) Proton MR spectroscopy in the evaluation of multiple sclerosis in humans in-vivo: assessment of the load of disease. In Book of Abstracts: Society of Magnetic Resonance in Medicine; 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine; 8th Annual Meeting (vol. 2), p. 455. Berkeley, California: SMRM.Google Scholar
Azzopardi, D., Wyatt, J. S., Hamilton, P. A., et al (1989a) Phosphorus metabolites and intracellular pH in the brains of normal and small-for-gestational age infants investigated by magnetic resonance spectroscopy. Paediatric Research, 25, 440–444.Google Scholar
Azzopardi, D., Wyatt, J. S., Cady, E. B., et al (1989b) Prognosis of newborn infants with hypoxic-ischaemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Paediatric Research, 25, 445–451.Google Scholar
Bartels, M., Albert, K., Kruppa, G., et al (1986) Fluorinated psychopharmacological agents: non-invasive observation by fluorine-19 nuclear magnetic resonance. Psychiatry Research, 25, 73–79.Google Scholar
Bottomley, P. A. (1988) Human in-vivo NMR spectroscopy in diagnostic medicine: clinical tool or research probe? Radiology, 170, 1–15.Google Scholar
Bottomley, P. A., Hart, H. R., Edelstein, W. A., et al (1984) Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla. Radiology, 150, 441–446.Google Scholar
Bottomley, P. A., Drayer, B. P. & Smith, L. S. (1986) Chronic adult cerebral infarction studied by phosphorus NMR spectroscopy. Journal of Radiology, 160, 763–766.Google Scholar
Bottomley, P. A., Hardy, C. J., Cousins, J., et al (1989) Brain phosphate metabolite concentrations, not ratios, are reduced in AIDS dementia. In Book of Abstracts: Society of Magnetic Resonance in Medicine; 8th Annual Meeting (vol. 1), p. 369. Berkeley, California: SMRM.Google Scholar
Buchthal, S. D., Thoma, W. J., Taylor, J. S., et al (1989) In-vivo T 1 values of phosphate metabolites in human liver and muscle determined at 1.5T by chemical shift imaging. NMR in Biomedicine, 2, 298–304.Google Scholar
Cadoux-Hudson, T. A. D., Blackledge, R. B., Taylor, D. J., et al (1989) Human primary brain tumour metabolism in-vivo: a phosphorus magnetic resonance spectroscopy study. British Journal of Cancer, 60, 430–436.Google Scholar
Cady, E. B., Costello, A. M. de L., Dawson, M. J., et al (1983) Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet, i, 1059–1062.Google Scholar
Cady, E. B. & Azzopardi, D. (1989) Absolute quantitation of neonatal brain spectra acquired with surface coil localisation. NMR in Biomedicine, 2, 305–311.Google Scholar
Chance, B. (1989) What are the goals of magnetic resonance research? NMR in Biomedicine, 2, 179–187.Google Scholar
Chance, B., Leigh, J. S., Nioka, S., et al (1987) An approach to the problem of metabolic heterogeneity in brain ischemia and reflow after ischemia. Annals of the New York Academy of Science, 508, 309–320.Google Scholar
Drayer, B. P. (1988) Brain imaging and spectroscopy. In Biomedical Magnetic Resonance Imaging (eds Wehrli, F., Shaw, D. & Kneeland, J.), pp. 225–278. New York: VCH Publishers.Google Scholar
Edwards, R. H. T., Dawson, M. J., Wilkie, D. R., et al (1982) Clinical use of nuclear magnetic resonance in the investigation of myopathy. Lancet, i, 725–731.Google Scholar
Edwards, R. H. T., Griffiths, R. D., Radda, G. K., et al (1985) Physiological and metabolic consequences of a defect in mitochondrial pyruvate oxidation. In Book of Abstracts: Society for Magnetic Resonance in Medicine; 4th Annual Meeting (vol. 3), p. 1221. Berkeley, California: SMRM.Google Scholar
Eleff, S. M., Barker, P. B., Blackband, S. J., et al (1989) Phosphorus magnetic resonance spectroscopy of patients with mitochondrial encephalopathies. In Book of Abstracts: Society of Magnetic Resonance in Medicine; 8th Annual Meeting (vol. 2), p. 451. Berkeley, California: SMRM.Google Scholar
Frahm, J., Michaelis, T., Merboldt, K. D., et al (1989) Localized NMR spectroscopy in-vivo. NMR in Biomedicine, 2, 188–195.Google Scholar
Gadian, D. G. (1989) Overview of spectral localization techniques. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 78. Berkeley, California: SMRM.Google Scholar
Griffiths, R. D. & Edwards, R. H. T. (1988) The biomedical applications of spectroscopy and spectrally resolved imaging. In Biomedical Magnetic Resonance Imaging: Principles, Methodology and Applications (eds Wehrli, F., Shaw, D. & Kneeland, J.). New York: VCH Publishers.Google Scholar
Hamilton, P. A., Hope, P. L., Costello, A. M. de L., et al (1985) Relation between PCr/Pi ratio in the brain of newborn infants, survival and early neurodevelopmental outcome. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), pp. 724–725. Berkeley, California: SMRM.Google Scholar
Hope, P. L., Costello, A. M. de L., Cady, E. B., et al (1984) Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth asphyxiated infants. Lancet, ii, 366–370.Google Scholar
Hubesch, B., Sappey-Marinier, D., Deiken, R., et al (1989a) Regional differences of phosphorus metabolites in the human brain. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), p. 447. Berkeley, California: SMRM.Google Scholar
Hubesch, B., Sappey-Marinier, D., Roth, K., et al (1990) P-31 MR spectroscopy of normal human brain and brain tumours. Radiology, 174, 401–409.Google Scholar
Komoroski, R. A., Newton, J. E. O., Karson, C., et al (1989) Detection of psychoactive drugs in-vivo in human brain using 19F NMR spectroscopy. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), p. 444. Berkeley, California: SMRM.Google Scholar
Komoroski, R. A., Newton, J. E. O., Cardwell, D., et al (1990) 7Li imaging and localised spectroscopy in-vivo. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 478. Berkeley, California: SMRM.Google Scholar
Keshavan, M. S., Pettegrew, J. W., Panchalingam, K., et al (1989) In-vivo 31P nuclear magnetic resonance (NMR) spectroscopy of the frontal lobe metabolism in neuroleptic naive first episode psychoses: preliminary studies (abstract). Schizophrenia Research, 2, 122.Google Scholar
Jenson, J. A. L., Luten, P. R., Meiners, L. C., et al (1989) In-vivo 1H MRS in the study of basal ganglia pathology associated with inborn errors of metabolism: potential for clinical use. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 373. Berkeley, California: SMRM.Google Scholar
Lancet (1989) Schizophrenia and organic disease. Lancet, ii, 776–777.Google Scholar
Lear, J. L. (1990) Glycolysis: link between PET and proton MR spectroscopic studies of the brain. Radiology, 174, 328–330.Google Scholar
Lenkinski, R. E., Rango, M., Gennarelli, T., et al (1989) Integrated MRI/31-P MRS studies of patients with acute head injury. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 453. Berkeley, California: SMRM.Google Scholar
Levine, S. R., Welch, K. M. A., Helpern, J. A., et al (1987) Clinical investigation of ischaemic stroke by serial 31-phosphorus NMR spectroscopy. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 6th Annual Meeting (vol. 2), p. 536. Berkeley, California: SMRM.Google Scholar
Luvten, P. R., Van Rijen, P. C., Tulleken, C. A.F., et al (1989a) Metabolite mapping using 1H NMR spectroscopic imaging in patients with cerebrovascular disease. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 452. Berkeley, California: SMRM.Google Scholar
Luvten, P. R., Den Hollander, J. A., Bovee, W. M. M. J., et al (1989b) 31P and 1H NMR spectroscopy of the human brain in chronic hepatic encephalopathy. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 375. Berkeley, California: SMRM.Google Scholar
McCulloch, J. (1982) Mapping functional alterations in the CNS with 14C-deoxyglucose. In Handbook of Psychopharmacology, vol. 15; New Techniques in Psychopharmacology (eds Iverson, L. L. et al). New York: Plenum.Google Scholar
Martin, P. A., Griffiths, R. D., Smith, S. R., et al (1988) Metabolite ratios in human muscle with depth resolved 31P MRS. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 7th Annual Meeting (vol. 2), p. 939. Berkeley, California: SMRM.Google Scholar
Matthews, P. M. & Arnold, D. L. (1989) In-vivo proton magnetic resonance spectroscopy in the study of focal epilepsy in man. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 371. Berkeley, California: SMRM.Google Scholar
Mooyart, E. L., Kamman, R. L., Minderhoud, J. M., et al (1989) 31P NMR spectroscopy in patients with multiple sclerosis (MS). A correlation with clinical data. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 456. Berkeley, California: SMRM.Google Scholar
Narayana, P. A., Wolinsky, J. S. & Fenstermacher, M. J. (1989) Proton magnetic resonance spectroscopy in multiple sclerosis. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), p. 457. Berkeley, California: SMRM.Google Scholar
Noguchi, S. & Toshirou, F. (1989) Application of 31P magnetic resonance imaging to senile dementia of Alzheimer's type. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), p. 669. Berkeley, California: SMRM.Google Scholar
Novotny, E. J., Avison, M. J., Rothman, D. L., et al (1989) Detection of phenylalanine in the human brain. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), p. 441. Berkeley, California: SMRM.Google Scholar
O'Callaghan, E. M., Larkin, C., Redmond, O., et al (1989) 31P magnetic resonance spectroscopy of the left temporal lobe in schizophrenia: procedures and preliminary results (abstract). Schizophrenia Research, 2, 125.Google Scholar
Perman, W. H. & Turski, P. (1988) Multinuclear magnetic resonance imaging. In Biomedical Magnetic Resonance Imaging, pp. 421–468. New York: VCH Publishers.Google Scholar
Petroff, O. A. C., Prichard, J. W. & Behar, K. L. (1984) In-vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus. Annals of Neurology, 16, 169–177.Google Scholar
Petroff, O. A. C., Novotny, E. J., Avison, M. J., et al (1989) Cerebral lactate turnover after electroshock by proton observed carbon decoupled spectroscopy. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 332. Berkeley, California: SMRM.Google Scholar
Pettegrew, J. W., Withers, G., Panchalingam, K., et al (1987) 31P nuclear magnetic resonance (NMR) spectroscopy of brain in ageing and Alzheimer's disease. Journal of Neural Transmission (suppl.), 24, 261–268.Google Scholar
Pettegrew, J. W., Moossy, J., Withers, G., et al (1988) 31P nuclear magnetic resonance study of the brain in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology, 47, 235–248.Google Scholar
Pettegrew, J. W., Panchalingam, K., Moossy, J., et al (1988b) Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease. Archives of Neurology, 45, 1093–1096.Google Scholar
Radda, G. K. (1986) The use of NMR spectroscopy for the understanding of disease. Science, 233, 640–645.Google Scholar
Pettegrew, J. W., (1990) some new insights in biology and medicine through NMR spectroscopy. In Proceedings from The Royal Society Discussion Meeting: June 1990; NMR Imaging; Recent Developments and Future Prospects. London: Royal Society.Google Scholar
Pettegrew, J. W., Rajagopalan, B. & Taylor, D. J. (1989) Biochemistry in-vivo: an appraisal of chemical magnetic resonance spectroscopy. Magnetic Resonance Quarterly, 9, 122–151.Google Scholar
Renshaw, P. F., Haselgrove, J. C., Leigh, J. S., et al (1985) In vivo nuclear magnetic resonance imaging of lithium. Magnetic Resonance, 2, 572.Google Scholar
Renshaw, P. F. & Wicklund, S. (1988) In-vivo measurement of lithium in humans by nuclear magnetic resonance spectroscopy. Biological Psychiatry, 23, 465–475.Google Scholar
Ross, B. & Naraimhan, P. T. (1989) Amplification or obfuscation: is localisation improving our clinical understanding of phosphorus metabolism? NMR in Biomedicine, 2, 340–345.Google Scholar
Sappey-Marinier, D., Hubesch, B., Fine, G., et al (1989) Altered 31P metabolites and pH in chronic stroke and deep white matter lesions. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 2), p. 1070. Berkeley, California: SMRM.Google Scholar
Segebarth, C. M., Baleriaux, D. F., Arnold, D. L., et al (1987) MR image-guided P-31 MR spectroscopy in the valuation of brain tumor treatment. Radiology, 165, 215–219.Google Scholar
Shulman, R. G., Rothman, D. L., Sulman, G. I., et al (1990) 13C and 1H NMR studies of metabolic rates in humans. In Proceedings from The Royal Society Discussion Meeting, June 1990: NMR Imaging: Recent Developments and Future Prospects in Proceedings from The Royal Society Discussion Meeting, June 1990: NMR Imaging: Recent Developments and Future Prospects. London: Royal Society.Google Scholar
Shaw, D. (1988) The fundamental principles of nuclear magnetic resonance. In Biomedical Magnetic Resonance Imaging (eds Wehrli, F., Shaw, D. & Kneeland, J. B.), pp. 1–45. New York: VCH Publishers.Google Scholar
Smith, L. S., Bottomley, P. A., Drayer, B. P., et al (1986) Localised clinical 31P NMR spectroscopy in Huntington's, Parkinson's, Alzheimer's and Binswanger's diseases. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 5th Annual Congress (vol. 4), p. 1386–1387. Berkeley, California: SMRM.Google Scholar
Szasz, T. S. (1961) The Myth of Mental Illness. London: Secher & Warburg.Google Scholar
Tofts, P. S. & Wray, S. (1987) Noninvasive measurement of molar concentrations of 31P metabolites in vivo, using surface coil NMR spectroscopy. Magnetic Resonance in Medicine, 6, 84–86.Google Scholar
Tofts, P. S. & Wray, S. (1988) A critical assessment of methods of measuring metabolite concentrations by NMR spectroscopy. NMR in Biomedicine, 1, 1–10.Google Scholar
Thorp, D., Owens, R. G., Whitehouse, G., et al (1990) Subjective experiences of magnetic resonance imaging. Clinical Radiology, 41, 276–278.Google Scholar
Van Rijen, P. C., Luyten, P. R., Den Hollander, J. A., et al (1989) Prolonged elevation of cerebral lactate detected with 1H NMR spectroscopy in patients with local cerebral ischaemia. In Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting in Book of Abstracts: Society of Magnetic Resonance in Medicine, 8th Annual Meeting (vol. 1), p. 374. Berkeley, California: SMRM.Google Scholar
Weiner, M. W., Hetherington, H., Hubesch, B., et al (1989) Clinical magnetic resonance spectroscopy of brain, heart, liver, kidney and cancer. NMR in Biomedicine, 2, 290–297.Google Scholar
Welch, K. M. A., Helpern, J. A., Robertson, W. M., et al (1985) 31P topical magnetic resonance measurement of high energy phosphates in normal and infarcted brain. Stroke, 16, 151.Google Scholar
Wirwicz, A. M., Pszenny, M. H., Schofield, J. C., et al (1983) Noninvasive observations of fluorinated anaesthetics in rabbit brain by fluorine 19 nuclear magnetic resonance. Science, 222, 428–431.Google Scholar
Young, I. R., Cox, I. J., Coutts, G. A., et al (1989) Some considerations concerning susceptibility, longitudinal relaxation time constants and motion artifacts in-vivo human spectroscopy. NMR in Biomedicine, 2, 329–339.Google Scholar
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