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Further Report on Prophylactic Lithium in Recurrent Affective Disorders

Published online by Cambridge University Press:  29 January 2018

R. P. Hullin ,
R. McDonald  and
M. N. E. Allsopp
R. P. Hullin
Affiliation:
Department of Biochemistry, University of Leeds, and Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, LS29 6AQ
R. McDonald
Affiliation:
High Royds Hospital
M. N. E. Allsopp
Affiliation:
Departments of Psychiatry and Biochemistry, University of Leeds, Leeds 2
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Extract

Evidence continues to accumulate for the proposition that lithium salts have a marked prophylactic effect on recurrent affective disorders. An earlier paper (1), together with reports from Baastrup et al. (2) and Coppen et al. (3) indicate that this effect is a strong one. This paper reports the current position regarding a trial in one centre which has been in progress for eight years, in which the effect of lithium was investigated on the frequency of admission to and time spent in psychiatric hospitals.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 126 , Issue 3 , March 1975 , pp. 281 - 284
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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References

Hullen, R. P., McDonald, R. & Allsopp, M. N. E. (1972) Prophylactic lithium in recurrent affective disorders. Lancet, i, 1044–6.Google Scholar
Baastrup, P. C., Poulsen, J. C., Schou, M., Thomsen, K. & Amdisen, A. (1970) Prophylactic lithium: Double-blind discontinuation in manic-depressive and recurrent depressive disorders. Lancet, ii, 326–30.Google Scholar
Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. S., Hare, E. H., Gardner, R. & Maggs, R. (1971) Prophylactic lithium in affective disorders. Controlled trial. Lancet, ii, 275–9.Google Scholar
Birch, N. J. & Hullin, R. P. (1972) The distribution and binding of lithium following its long-term administration. Life Science (II), 11, 1095–9.Google Scholar
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Hullin, R. P., Swinscoe, J. C., McDonald, R. & Dransfeld, G. A. (1968) Metabolic balance studies on the effect of lithium salts in manic-depressive psychosis. British J. Psychiat., 114, 1561–73.Google Scholar
Angst, J., Weis, P., Grof, P., Baastrup, P. C. & Schou, M. (1970) Lithium prophylaxis in recurrent affective disorders. Brit. J. Psychait., 116, 604–14.Google Scholar
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