Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-24T19:43:55.361Z Has data issue: false hasContentIssue false
  • English
  • Français

A Controlled Trial of L-Tryptophan in Mania

Published online by Cambridge University Press:  29 January 2018

C. A. Chambers  and
G. J. Naylor
C. A. Chambers
Affiliation:
Royal Dundee Liff Hospital, By Dundee
G. J. Naylor
Affiliation:
Department of Psychiatry, The University, Dundee
Get access Rights & Permissions [Opens in a new window]

Summary

A double-blind placebo-controlled trial of L-tryptophan, with pyridoxine and ascorbic acid, was carried out in 10 female patients suffering from mania.

In contrast to earlier studies led by Prange and Murphy, L-tryptophan was found to be no better than placebo.

Type
Papers
Information
The British Journal of Psychiatry , Volume 132 , Issue 6 , June 1978 , pp. 555 - 559
Copyright
Copyright © Royal College of Psychiatrists, 1978 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beigel, A., Murphy, D. L. & Bunney, W. E. Jnr. (1971) The Manic State Racing Scale. Archives of General Psychiatry, 25, 257–62.Google Scholar
Bowers, M. B. Jnr. (1970) Cerebrospinal fluid 5, hydroxyindoles and behaviour after L-tryptophan and pyridoxine administration to psychiatric patients. Neuropharmacology, 9, 599–604.CrossRefGoogle ScholarPubMed
Carroll, B. J., Mowbray, R. M. & Davies, B. (1970) Sequential comparison of L-tryptophan with ECT in severe depression. Lancet i, 967–9.Google Scholar
Coppen, A., Shaw, D. M. & Farrel, J. (1963) Potentiation of the antidrepressive effect of a monoamine oxidase inhibitor by tryptophan. Lancet i, 79–81.CrossRefGoogle Scholar
Coppen, A., Shaw, D. M. Herzberg, B. & Maggs, R. (1967) Tryptophan in the treatment of depression. Lancet, ii, 1178–80.Google Scholar
Coppen, A., Whybrow, P. C., Noguera, R., Maggs, R. & Prange, A. J. Jnr. (1972) The comparative antidepressant value of L-tryptophan and imipramine with and without the attempted potentiation of L-thyronine. Archives of General Psychiatry, 26, 234–41.Google Scholar
Gayford, J. J., Parker, A. L., Phillips, E. M. & Rowsell, A. R. (1973) Whole blood 5. hydroxytryptamine during treatment of endogenous depressive illness. British Journal of Psychiatry, 122, 597–8.Google ScholarPubMed
Classman, A. H. & Platman, S. R. (1969) Potentiation of monoamine oxidase inhibitor by tryptophan. Journal of Psychiatric Research, 7, 83–8.Google Scholar
Herrington, R. N., Bruce, A. & Johnston, E. C. (1974) Comparative trial of L-tryptophan and ECT in severe depressive illness. Lancet, ii 731–4.Google Scholar
Herrington, R. N., Bruce, A. Johnston, E. C. & Lader, M. N. (1976) Comparative trial of L-tryptophan and amitiiptyline in depressive illness. Psychological Mediant, 6, 673–8.Google ScholarPubMed
Jensen, K. S., Ahlfors, U. G., Ose, E. & Dencker, S. J. (1975) Tryptophan/imipramine in depression. Lancet ii 920.CrossRefGoogle Scholar
MacSweeney, D. A. (1975) Treatment of unipolar depression. Lancet, ii, 510–11.Google Scholar
Maxwell, A. E. & Pilliner, A. E. G. (1968) Deriving coefficients of reliability and agreement for ratings. British Journal of Mathematical and Statistical Psychology, 21, 105–16.CrossRefGoogle ScholarPubMed
Mendels, J., Stinnett, J. L., Burns, D. & Fraser, A. (1975) Amine precursors and depression. Archives of General Psychiatry, 32, 22–30.Google ScholarPubMed
Murphy, D. L., Baker, M., Goodwin, K., Miller, H., Kotin, J. & Bunney, W. E. Jnr. (1974) Tryptophan in affective disorders: indoleamine changes and differential clinical effects. Psychopharmacologia, Berlin, 34, 11–20.CrossRefGoogle ScholarPubMed
Prance, A. J., Wilson, I. C. & Lynn, C. W. (1974) L-tryptophan in mania. Archives of General Psychiatry, 30, 56–62.Google Scholar
Shaw, D. M., MacSweeney, D. A., Hewland, R. & Johnston, A. (1975) Tricyclic antidepressants and tryptophan in unipolar depression. Psychological Medicine, 5, 276–8.Google ScholarPubMed
Wålinder, J., Scott, A., Nagy, A., Carlsson, A. & Roos, B. E. (1975) Potentiation of antidepressant action of clomipramine by tryptophan. Lancet, ii, 984.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.