Hostname: page-component-6bf8c574d5-vmclg Total loading time: 0 Render date: 2025-02-17T15:40:34.032Z Has data issue: false hasContentIssue false
  • English
  • Français

A Clinical Trial of Phenelzine in Anxiety Depressive and Phobic Neuroses

Published online by Cambridge University Press:  29 January 2018

C. Q. Mountjoy ,
Martin Roth ,
R. F. Garside  and
I. M. Leitch
C. Q. Mountjoy
Affiliation:
University Department of Psychological Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP
Martin Roth
Affiliation:
University Department of Psychological Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP
R. F. Garside
Affiliation:
University Department of Psychological Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP
I. M. Leitch
Affiliation:
University Department of Psychological Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP
Get access Rights & Permissions [Opens in a new window]

Abstract

A double-blind clinical trial of phenelzine and diazepam against placebo and diazepam in neurotic patients over a four-week period showed phenelzine to be superior to placebo on three rating scales in some groups of patients who completed the trial. The findings suggest that phenelzine may exert a beneficial effect on some as yet undefined features of anxiety and depression which were not revealed by a multiple regression analysis of clinical symptomatology or premorbid personality.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 131 , Issue 5 , November 1977 , pp. 486 - 492
Copyright
Copyright © Royal College of Psychiatrists, 1977 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

British Pharmaceutical Codex (1968) London: The Pharmaceutical Press, pp 598–99.Google Scholar
Dally, P. J. & Rohde, P. (1961) Comparison of antidepressant drugs in depressive illness. Lancet, i, 18–20.Google Scholar
Gelder, M. G. & Marks, I. M. (1966) Severe agoraphobia: a controlled prospective trial of behaviour therapy. British Journal of Psychiatry, 112, 309–19.Google Scholar
Glick, B. S. (1964) Double-blind study of tranylcypromine and phenelzine in depression. Diseases of the Nervous System, 25, 617–19.Google Scholar
Goodman, L. S. & Gilman, A. (1970) The Pharmacological Basis of Therapeutics, 4th edition, p 184. London: Collier-MacMillan Ltd Google Scholar
Greenblatt, M., Grosser, G. H. & Wechsler, H. (1964) Differential response of hospitalized depressed patients to somatic therapy. American Journal of Psychiatry, 120, 935–43.Google Scholar
Gurney, C., Roth, M., Garside, R. F., Kerr, T. A. & Schapira, K. (1972) Studies in the classification of affective disorders and the relationship between anxiety states and depressive illness. II. British Journal of Psychiatry, 121, 162–6.CrossRefGoogle Scholar
Hamilton, M. (1959) The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50–5.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–61.Google Scholar
Hare, E. H., Dominian, J. & Sharps, L. (1962) Phenelzine and dexamphetamine in depressive illness. British Medical Journal, i, 9–12.Google Scholar
Imlah, N. W., Fahy, P. T. P. & Harrington, J. A. (1964) A comparison of two antidepressant drugs. Psychopharmacologia, 6, 472–4.Google Scholar
Johnstone, E. C. & Marsh, W. (1973) Acetylator status and response to phenelzine in depressed patients. Lancet, i, 567–70.Google Scholar
Kay, D. W. K., Garside, R. F. & Fahy, T. J. (1973) A double-blind trial of phenelzine and amitriptyline in depressed out-patients: a possible differential effect of the drugs on symptoms. British Journal of Psychiatry, 123, 63–7.CrossRefGoogle ScholarPubMed
Kelly, D., Guirguis, W., Frommer, E., Mitchell-Heggs, N. & Sargant, W. (1970) Treatment of phobic states with antidepressants: a retrospective study of 246 patients. British Journal of Psychiatry, 116, 387–98.CrossRefGoogle ScholarPubMed
Kerr, T. A., Roth, M., Schapira, K. & Gurney, C. (1972) The assessment and prediction of outcome in affective disorders. British Journal of Psychiatry, 121, 167–74.Google Scholar
King, P. D. (1959) Phenelzine and ECT in the treatment of depressions. American Journal of Psychiatry, 116, 64–5.Google Scholar
Levy, L. & Lohrenz, J. (1960) the use of phenelzine sulphate (Nardil) in depression. Canadian Medical Association Journal, 82, 1031–2.Google Scholar
Lipsedge, M. S., Rees, W. L. & Pike, D. J. (1971) A double blind comparison of dothiepin and amitriptyline for the treatment of depression with anxiety. Psychopharmacologia (Berlin), 19, 153–62.Google Scholar
Martin, M. E. (1963) A comparative trial of imipramine and phenelzine in the treatment of depression. British Journal of Psychiatry, 109, 279–85.Google Scholar
Medical Research Council Report (1965) Clinical trial of the treatment of depressive illness. British Medical Journal, i, 881–6.Google Scholar
Mountjoy, C. Q. & Roth, M. (1975) A controlled trial of phenelzine in anxiety, depressive and phobic neuroses. Proceedings of the IXth Congress of the Collegium Internationale Neuropsychopharmacologicum. Paris 7–12 July 1974 (eds Boissier, J. R., Hippius, H. and Pichot, P.) (Excerpta Medica International Congress Series 359), pp 778–81.Google Scholar
Rao, C. R. (1952) Advanced Statistical Methods in Biometric Research, pp 112–15. New York: John Wiley Google Scholar
Raskin, A., Schulterbrandt, J. G., Reatig, N., Crook, T. H. & Odle, D. (1974) Depression subtypes and response to phelelzine, diazepam and a placebo. Archives of General Psychiatry, 30, 66–75.Google Scholar
Ravaris, C. L., Nies, A., Robinson, D. S., Ives, J. O., Lamborn, K. R. & Korson, L. (1976) A multiple-dose, controlled study of phenelzine in depression-anxiety states. Archives of General Psychiatry, 33, 347–50.Google Scholar
Rees, L. & Davies, B. (1961) A controlled trial of phenelzine (Nardil) in the treatment of severe depressive illness. Journal of Mental Science, 107, 560–66.Google ScholarPubMed
Robinson, D. S., Nies, A., Ravaris, C. L. & Lamborn, K. R. (1973) The monoamine oxidase inhibitor, phenelzine, in the treatment of depressive anxiety states. Archives of General Psychiatry, 29, 407–13.Google Scholar
Sargant, W. & Dally, P. (1962) Treatment of anxiety states by antidepressant drugs. British Medical Journal, i, 7–9.Google Scholar
Sargant, W. & Slater, E. (1972) An Introduction to Physical Methods of Treatment in Psychiatry, 5th edition, p 45. Edinburgh and London: Churchill Livingstone Google Scholar
Snatch, R. P., Ahmed, S. N., Mehta, S. & Hamilton, M. (1971) Assessment of the severity of primary de-depressive illness. Wakefield self-assessment depression inventory. Psychological Medicine, 1, 143–9.Google Scholar
Solyom, L., Heseltine, G. F. D., McClure, D. J., Solyom, C., Ledwidge, B. & Steinberg, G. (1973) Behaviour therapy versus drug therapy in the treatment of phobic neurosis. Canadian Psychiatric Association Journal, 18, 25–32.CrossRefGoogle ScholarPubMed
Tyrer, P., Candy, J. & Kelly, D. (1973) Phenelzine in phobic anxiety: a controlled trial. Psychological Medicine, 3, 120–4.CrossRefGoogle ScholarPubMed
Tyrer, P. (1976) Towards rational therapy with monoamine oxidase inhibitors. British Journal of Psychiatry, 128, 354–60.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.