Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-28T00:57:51.722Z Has data issue: false hasContentIssue false
  • English
  • Français

TRH Response Pattern in Adolescent Schizophrenic Males

Published online by Cambridge University Press:  29 January 2018

Lawrence DeMilio
Lawrence DeMilio*
Affiliation:
Fair Oaks Hospital, 19 Prospect Street, Summit, New Jersey 07901, USA
Get access Rights & Permissions [Opens in a new window]

Summary

A marked elevation in human growth hormone (GH) following intravenous infusion of thyrotropin releasing hormone (TRH) was seen in three of seven adolescent male schizophrenic patients receiving neuroleptic drugs, and in one of five controls matched for age, sex, and developmental stage, receiving the same drugs. A positive family history for schizophrenia was noted in all three schizophrenic ‘responders' but in only one of the remaining patients. The response patterns of thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4 following TRH infusion were not significantly different in the two groups. No significant correlations were found between T3, T4, TSH, or GH response patterns and age of patient, duration of illness, medication dose or duration, weight change, or hours of sleep preceding testing.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 6 , December 1984 , pp. 649 - 651
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Braddock, L. E. & Blake, I. M. (1981) Neuroendocrine tests during treatment with neuroleptic drugs: II. The TRH test. British Journal of Psychiatry, 139, 404–407.Google Scholar
Gil-Ad, I., Dickerman, Z., Weizman, R., Weizman, A., Tyano, S. & Laron, Z. (1981) Abnormal growth hormone response to LRH and TRH in adolescent schizophrenic boys. American Journal of Psychiatry, 138, 357–360.Google Scholar
Gold, M. S., Pottash, A. L. C., Extein, I., Martin, D. M., Howard, E., Mueller, E. A. & Sweeney, D. R. (1981) The TRH test in the diagnosis of major and minor depression. Psychoneuroendocrinology, 6, 159–169.CrossRefGoogle ScholarPubMed
Green, H. S. & Kane, J. (1982) Letter in Archives of General Psychiatry, 139, 1219–1220.CrossRefGoogle Scholar
Loosen, P. & Prange, A. (1982) Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: A review. American Journal of Psychiatry, 139, 405–416.Google Scholar
Martin, J. P., Reichlin, S. & Brown, G. M. (1977) Regulation of TSH secretion and its disorders. In Clinical Neuroendocrinology (ed. Plum, F.). Philadelphia: F. A. Davis.Google ScholarPubMed
Puig-Antich, J., Chambers, W., Orvaschel, H. & Tabrizi, M. A. (1978) The Schedule for Affective Disorders and Schizophrenia for School Age Children (Kiddie-SADS). Investigators wishing to use this instrument should contact Dr Puig-Antich at the Department of Child Psychiatry, New York State Psychiatric Institute, 722 West 168th Street, New York.Google Scholar
Puig-Antich, J. & Goetz, R. (1982) Sleep architecture and REM sleep measures in prepubertal children with major depression: A controlled study. Archives of General Psychiatry, 39, 932–939.CrossRefGoogle ScholarPubMed
Shopsin, B. (1970) Effects of lithium on thyroid function: A review. Diseases of the Nervous System, 31, 237–244.Google Scholar
Spitzer, R. L., Endicott, J. & Robbins, E. (1975) Research Diagnostic Criteria for a selected group of functional disorders. 2nd edition NYC: New York State Psychiatric Institute, Biometrics Research.Google Scholar
Weizman, R., Weizman, A., Gil-Ad, I., Tyano, S. & Laron, Z. (1982) Abnormal Growth hormone response to TRH in chronic adolescent schizophrenic patients. British Journal of Psychiatry, 141, 582–585.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.