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Psychological Effects, Compliance, and Response to Long-Term Lithium

Published online by Cambridge University Press:  29 January 2018

B. Müller-Oerlinghausen*
Affiliation:
Department of Psychiatry, Laboratory of Clinical Psychopharmacology, Free University of Berlin, Eschenallee 3, D-1000 Berlin 19 (West), Germany

Summary

The most relevant psychological and neuropsychophysiological effects induced by lithium in healthy volunteers or in patients during the free interval are changes of vigilance and possible changes in patients' personality. In EEG terms lithium acts as a “chopper” and induces left-hemispheric asymmetry. Interesting concepts for description of personality changes are the typus melancholicus of Tellenbach and the psychoanalytical view of depression. Effects in an individual patient are heterogeneous and cannot be predicted. Primary and secondary psychological effects may influence compliance, and a detailed analysis of compliance seems necessary.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

Arnold, O. H. (1974) Weitere Beobachtungen zum “automatenhaften Dasein” unter Lithium-Langzeit-Therapie. Drug Research, 24, 1125–7.Google Scholar
Aschayeri, H., Becker, W. & Bockenheimer, S. (1977) Wirkung von Lithium bei gesunden Probanden im Selbstversuch. Nervenarzt, 48, 575–7.Google Scholar
Bente, D. (1964) Die Insuffizienz des Vigilitätstonus. Erlangen: Habilitations Schrift.Google Scholar
Bente, D., Kriebitzsch, R. & Scheuler, W. (1980) Untersuchung zur Wirkung einer zweiwöchigen Lithiumapplikation auf die hirnelektrische Wachaktivität gesunder Probanden während der Durchführung einer visuo-motorischen Regelaufgabe. Drug Research, 30, 1223.Google Scholar
Bente, D., Scheuler, W., Ulrich, G. & Müller-Oerlinghausen, B. (1982) Effects of lithium on the EEG of healthy subjects and psychiatric patients: Methods, results, and hypotheses. In Electroencephalography in Drug Research (ed. Herrmann, W. M.). Stuttgart: G. Fischer.Google Scholar
Bonetti, U., Johansson, F., Von Knorring, L., Perris, C. & Strandman, E. (1977) Prophylactic lithium and personality variables. International Pharmacopsychiatry, 12, 1419.Google Scholar
Christodoulou, G. N., Kokkevi, A., Lykouras, E. P., Stefanis, C. N. & Papadimitriou, G. N. (1981) Effects of lithium on memory. American Journal of Psychiatry, 138, 847–8.Google Scholar
Czernik, A. (1978) EEG-Veränderungen unter lang-jähriger Lithium-behandlung. Psychiatria clinica, 11, 189–97.Google Scholar
Donnelly, E. F., Murphy, D. L. & Waldman, I. N. (1979) Obsessionalism and response to lithium. British Medical Journal, 1, 1627.Google Scholar
Düker, H. (1975) Untersuchungen über die Ausbildung des Wollens. Bern, Stuttgart, Vienna: Hans Huber.Google Scholar
Glatzel, J. (1974) Kritische Anmerkungen zum “Typus Melancholicus” “Tellenbach”. Archiv fur Psychiatrie und Nervenkrankenheit, 219, 197206.Google Scholar
Helmchen, H. & Kanowski, S. (1970) Ergebnisse elektroenzephalographischer Untersuchungen zur Lithiumwirkung. International Pharmacopsychiatry, 5, 149–61.Google Scholar
Herrmann, W. M., Kropf, D., Fichte, K. & Müller-Oerlinghausen, B. (1980) Electroenzephalographische und psychoexperimentelle Untersuchungen mit Lithium an gesunden Probanden. Pharmakopsychiatrie, 13, 200–12.Google Scholar
Insel, T. R., van Kammen, D. P., Cohen, R. M., Alterman, I. S. & Murphy, D. L. (1981) Lithium and mood change in affective disorder patients. Biological Psychiatry, 16, 1051–7.Google Scholar
Jamison, K. R., Gerner, R. H. & Goodwin, F. K. (1979) Patient and physician attitudes toward lithium. Archives of General Psychiatry, 36, 866–9.Google Scholar
Judd, L. L., Hubbard, B., Janowsky, D. S., Huey, L. Y. & Takahashi, K. I. (1977) The effect of lithium carbonate on the cognitive functions of normal subjects. Archives of General Psychiatry, 34, 355–7.Google Scholar
Judd, L. L. (1979) Effect of lithium on mood, cognition, and personality function in normal subjects. Archives of General Psychiatry, 36, 860–5.Google Scholar
Karniol, I. G., Dalton, J. & Lader, M. H. (1978) Acute and chronic effects of lithium chloride on physiological and psychological measures in normals. Psychopharmacology, 57, 289–94.Google Scholar
Kerry, R. J. & Orme, J. E. (1979) Lithium, manic-depressive illness, and psychological test performance. British Medical Journal, 1, 230–2.Google Scholar
Kropf, D. & Müller-Oerlinghausen, B. (1979) Changes in learning, memory, and mood during lithium treatment. Acta Psychiatrica Scandinavica, 59, 97124.Google Scholar
Kropf, D. (1980) Probleme und Konzepte der Lithium-Forschung aus psychologischer Sicht. Pharmakopsychiatrie, 13, 168–74.Google Scholar
Kropf, D. (1981) Wirkung von Lithium auf normale psychische Funktionen als Bedingungen für die Prophylaxe. In Aktuelle Perspektiven der Lithiumprophylaxe (ed. Berner, P.). Bibliotheca. psychiatrica , 161, 141–51. Basel: Karger.Google Scholar
Kropf, D. & Müller-Oerlinghausen, B. (1982) Studies on psychic conditions of the prevention of manic-depressive psychoses by lithium salts. Drug Research, 32, 883–4.Google Scholar
Linden, M. (1979) Therapeutische Ansätze zur Verbesserung von “Compliance”. Nervenarzt, 50, 109–14.Google Scholar
Linden, M. (1981) Definition of compliance. International Journal of Clinical Pharmacology, 19, 8690.Google Scholar
Loomis, A. L., Harvey, E. N. & Hobart, G. A. (1937) Cerebral states during sleep as studied by human brain potentials. Journal of Experimental Psychology, 21, 127–44.Google Scholar
Luccioni, H., Dufour, H., Warnery, F. & Scotto, J.-C. (1978) Psychological effects of lithium salts. Paper presented at the 11th C.I.N.P. Congress, Vienna.Google Scholar
Müller-Oerlinghausen, B. (1981) Probleme der Langzeitprophylaxe. In Aktuelle Perspektiven der Lithiumprophylaxe (ed. Berner, P.). Bibliotheca psychiatrica , 161, 224–26. Basel: Karger.Google Scholar
Müller-Oerlinghausen, B., Bauer, H., Girke, W., Kanowski, S. & Goncalves, N. (1977) Impairment of vigilance and performance under lithium-treatment. Studies in patients and normal volunteers. Pharmakopsychiatrie, 10, 6778.Google Scholar
Müller-Oerlinghausen, B. & Kropf, D. (1979) Effects of lithium on normal experience and behaviour. Conditional and descriptive approach to the structure of its action. In Origin Prevention and Treatment of Affective Disorders (eds. Stromgren, E. and Schou, M.). New York: Academic Press.Google Scholar
Müller-Oerlinghausen, B., Hamann, S., Herrmann, W. M. & Kropf, D. (1979) Effects of lithium on vigilance, psychomotoric performance, and mood. Pharmakopsychiatrie, 12, 388–96.Google Scholar
Opgenoorth, E., Erbich-Baumhackl, E., Lenz, G., Perlich, S. & Wyter, R. (1980) Reaktionsfähigkeit bei Lithiumprophylaxe. Pharmakopsychiatrie, 13, 182–99.Google Scholar
Pflug, B., Hartung, M. & Klemke, W. (1980) Die Beeinflussung von Befindlichkeit und Leistungsfähigkeit gesunder Versuchspersonen durch Lithiumkarbonat. Pharmakopsychiatrie, 13, 175–81.Google Scholar
Reus, V. I., Targum, S. D., Weingartner, H. & Post, R. M. (1979) Effect of lithium carbonate on memory processes of bipolar affectively ill patients. Psychopharmacology, 63, 3942.Google Scholar
Roth, B. (1961) The clinical and theoretical importance of EEG rhythms corresponding to states of lowered vigilance. Electroencephalography and Clinical Neurophysiology, 13, 395–9.Google Scholar
Rüger, U. (1977a) Intrapsychische und familiendynamische Prozesse vor der manifesten Erkrankung und während der Lithium-Therapie einer endogenen Depression. Zeitschrift für Psychosomatische Medizin und Psychoanalyse, 23, 329–50.Google Scholar
Rüger, U. (1977b) Modification of psychodynamic processes during long-term lithium therapy. Pharmakopsychiatrie, 10, 334–5.Google Scholar
Schou, M. (1968) Lithium in psychiatric therapy and prophylaxis. Journal of Psychiatric Research, 6, 6795.Google Scholar
Tellenbach, H. (1974) “Melancholie”. Berlin: Springer-Verlag.Google Scholar
Ulrich, G. (1979) Der Lateralitätsaspekt in der psychiatrischen Forschung. Fortschritte der Neurologie und Psychiatric, 47, 418–30.Google Scholar
Ulrich, G. (1980) Lateralization of hand-movements in patients with affective psychoses during an interview situation: An attempt at a physiological interpretation. Psychological Research, 41, 249–58.Google Scholar
Ulrich, G., Scheuler, W. & Müller-Oerlinghausen, B. (1982) Zur visuell-morphologischen Analyse des hirnelektrischen Verhaltens bei Patienten mit manischdepressiven und schizo-affektiven Psychosen unter Lithiumprophylaxe. Fortschritte der Neurologie und Psychiatrie, in press.Google Scholar
Van Putten, T. (1975) Why do patients with manic-depressive illness stop their lithium? Comprehensive Psychiatry, 16, 179–82.Google Scholar
Zerbi, F., Clemente, E., Bezzi, G. & Tosca, P. (1981) Memory performances in depressed patients during prophylactic treatment with lithium salts. In Aktuelle Perspektiven der Lithiumprophylaxe (ed. Berner, P.). Bibliotheca psychiatrica , 161, 190–6. Basel: Karger.Google Scholar
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