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PET Analysis Indicates Atypical Central Dopamine Receptor Occupancy in Clozapine-Treated Patients

Published online by Cambridge University Press:  06 August 2018

Lars Farde  and
A-L Nordstrom
Lars Farde*
Affiliation:
The Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01 Stockholm, Sweden
A-L Nordstrom
Affiliation:
The Ulf Lundahl Research Unit, Department of Psychiatry and Psychology, The Karolinska Institute, S-104 01 Stockholm, Sweden
*
Correspondence
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Abstract

D1 and D2 dopamine (DA) receptor occupancy was determined by PET in the basal ganglia of drug-treated schizophrenic patients. In 22 patients treated with classical neuroleptics at conventional doses, the average D2 occupancy was 78% (s.d. 6%). In five patients treated with the prototype atypical antipsychotic drug clozapine, a lower D2 occupancy of 48% (s.d. 11%, P<0.01) was found. Accordingly, clozapine is ‘atypical’ with respect to the striatal D2 DA receptor occupancy induced in patients. No obvious D1 DA receptor occupancy was induced by the classical neuroleptics haloperidol or sulpiride. The thioxanthene flupenthixol induced a 36-44% D1 occupancy in individual patients. In four patients treated with clozapine the D1 occupancy was 38-52%.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 160 , Issue S17: Clozapine - The Atypical Antipsychotic , May 1992 , pp. 30 - 33
Copyright
Copyright © The Royal College of Psychiatrists 

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