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Nelson's Syndrome and Behavioural Changes Reversed by Selective Adenomectomy

Published online by Cambridge University Press:  02 January 2018

Helen M. Buckler ,
Hugh Freeman ,
M. C. P. Chetty  and
D. C. Anderson
Helen M. Buckler
Affiliation:
Salford University
Hugh Freeman
Affiliation:
Salford University
M. C. P. Chetty
Affiliation:
Community Medicine
D. C. Anderson*
Affiliation:
Hope Hospital, Salford
*
∗Hope Hospital, Salford M6 8HD
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Abstract

A man with Nelson's syndrome developed severe associated behavioural and psychiatric problems, which completely resolved following selective resection of his pituitary tumour. It is postulated that ACTH, β-endorphin, or related peptides may have caused these problems.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 152 , Issue 3 , March 1988 , pp. 412 - 414
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Brambilla, F., Facchinetti, F., Petragla, F., Vanzulli, L. & Genazzani, A. (1984) Secretion pattern of endogenous opioids in chronic schizophrenia. American Journal of Psychiatry, 141, 1183–1189.Google Scholar
Boston Collaborative Drug Surveillance Programme (1972) Acute adverse reactions to prednisone in relation to dosage. Clinical Pharmacology and Therapeutics, 13, 694–698.Google Scholar
Cleghorn, R. A. (1951) Adrenal cortical insufficiency. Psychological and neurological observations. Canadian Medical Association Journal, 65, 449–454.Google Scholar
Cohen, S. (1980) Cushing's syndrome. A psychiatric study of 29 patients. British Journal of Psychiatry, 136, 120–124.CrossRefGoogle ScholarPubMed
De Kloet, E. R., Palkovits, M. & Mezey, E. (1986) Opioid peptides localisation, source, and avenues of transport. In Neuropeptides and Behaviour (eds Deweid, D. & Gispen, W. H.). New York: Pergamon.Google Scholar
De Weid, D. (1977) Peptides and behaviour. Life Sciences, 20, 195–204.Google Scholar
Hall, R. C. W., Popkin, M. K., Stickney, S. K. & Gardner, E. R. (1979) Presentation of the steroid psychoses. Journal of Nervous and Mental Diseases, 167, 229–236.CrossRefGoogle ScholarPubMed
Howlett, T. A., Drury, P. L., Perry, L., Doniach, I., Rees, L. H. & Besser, G. M. (1986) Diagnosis and management of ACTH dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production. Clinical Endocrinology, 24, 699–713.Google Scholar
Lindstrom, L. H., Widerlov, E., Gunne, L. M., Wahlström, A. & Terenius, L. (1978) Endorphins in human cerebrospinal fluid: clinical correlations to some psychotic states. Acta Psychiatrica Scandinavica, 57, 153–164.CrossRefGoogle ScholarPubMed
MacFarland, H. R. (1963) Addison's disease and related psychoses. Comprehensive Psychiatry, 4, 90–95.Google Scholar
Mattison, B. (1974) Addison's disease and psychoses. Acta Psychiatrica Scandinavica, 255, Suppl. 203–210.Google Scholar
Nakao, K., Nakai, Y. & Oki, S. (1978) Presence of immuno-reactive-endorphin in normal human plasma. Journal of Clinical Investigation, 68, 1395–1398.Google Scholar
Sandman, C. A., George, J. M., Nolan, J. D., Van Riezen, H. & Kastin, A. J. (1975) Enhancement of attention in man with ACTH/MSH 4–10. Physiology of Behaviour, 15, 427–431.Google Scholar
Sandman, C. A., Walker, B. B. & Lawton, C. A. (1980) An analog of MSH/ACTH 4–10 enhances interpersonal and environmental awareness in mentally retarded adults. Peptides, 1, 109–114.CrossRefGoogle Scholar
Starkman, M. & Schteingart, D. (1981) Neuropsychiatric manifestations of patients with Cushing's syndrome. Archives of Internal Medicine, 141, 215–219.Google Scholar
Suda, T., Abe, Y., Demura, H., Demura, R., Schizuma, K., Tamahashi, N. & Sassumo, N. (1979) ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of -LPH conversion to -endorphin. Journal of Clinical Endocrinology and Metabolism, 49, 475–477.Google Scholar
Terenius, L., Wahlstrom, A., Lindstrom, L. et al (1976) Increased CSF levels of endorphins in chronic psychosis. Neuroscience Letters, 3, 157–162.Google Scholar
Treadwell, B. L. J., Sever, E. D., Savage, O. & Copeman, W. S. C. (1964) Side effects of long-term treatment with corticosteroids and corticotrophin. The Lancet, i, 1121–1123.Google Scholar
Trethowan, W. H. & Cobb, S. (1952) Neuropsychiatric aspects of Cushing's syndrome. Archives of Neurology and Psychiatry, 67, 283–309.Google Scholar
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