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Life Events and Maintenance Therapy in Schizophrenic Relapse

Published online by Cambridge University Press:  29 January 2018

J. P. Leff ,
S. R. Hirsch ,
R. Gaind ,
P. Rohde  and
B. C. Stevens
J. P. Leff
Affiliation:
Medical Research Council, Social Psychiatry Unit, Institute of Psychiatry; Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF
S. R. Hirsch
Affiliation:
Westminster Medical School, Queen Mary's Hospital, Roehampton, London, S.W.15
R. Gaind
Affiliation:
Guy's Hospital, London, S.E.1
P. Rohde
Affiliation:
St. Mary Abbot's Hospital, Marloes Road, London, W.8
B. C. Stevens
Affiliation:
Medical Research Council, General Practice Research Unit, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF
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Extract

The possible role of environmental stress in precipitating the onset or relapse of acute schizophrenia was investigated by Brown and Birley (1968), Birley and Brown (1970). They enquired about events which could be dated to a definite point in time and which usually involved either actual or threatened danger or important fulfilments or disappointments. They distinguished between independent events, which were outside the control of the subject, and possibly independent events, which were not so clearly out of his control but which seemed unlikely to be produced by unusual behaviour of the subject himself. In their main group of patients a significant concentration of independent events (about 60 per cent) was found in the three weeks preceding onset or relapse of schizophrenia. In examining two small sub-groups they found that 4 of 13 patients (31 per cent) who relapsed after reducing or discontinuing phenothiazine therapy had experienced a life event in the three weeks before relapse, compared with 3 of 5 patients (60 per cent) who had been taking phenothiazines regularly at the time of relapse. Although these proportions are very different, the numbers in the groups are too small for the difference to reach significance. Furthermore the groups were not matched in any way, and there may be important differences between patients who discontinue medication themselves and those who carry on taking it regularly.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 123 , Issue 577 , December 1973 , pp. 659 - 660
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

Brown, G. W., and Birley, J. L. T. (1968). ‘Crises and life changes and the onset of schizophrenia.’ Journal of Health and Social Behaviour, 9, 203–14.Google Scholar
Brown, G. W., Birley, J. L. T. and Wing, J. K. (1972). ‘Influence of family life on the course of schizophrenic disorders: a replication.’ British Journal of Psychiatry, 121, 241–58.Google Scholar
Birley, J. L. T., and Brown, G. W. (1970). ‘Crises and life changes preceding the onset or relapse of schizophrenia: clinical aspects.’ British Journal of Psychiatry, 116, 327–33.CrossRefGoogle ScholarPubMed
Hirsch, S. R., Gaind, R., Rohde, P. D., Stevens, B. C., and Wing, J. K. (1973). ‘Out-patient maintenance of chronic schizophrenic patients with long-acting fluphenazine: a double-blind placebo trial’. British Medical Journal. (627–688)Google Scholar
Left, J. P., and Wing, J. K. (1971). ‘Trial of maintenance therapy in schizophrenia.’ British Medical Journal, iii, 599–604.Google Scholar
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