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Ethanol Retards Desensitisation of Simple Phobias in Non-alcoholics

Published online by Cambridge University Press:  02 January 2018

O. G. Cameron*
Affiliation:
University of Michigan
M. R. Liepman
Affiliation:
University of Michigan
G. C. Curtis
Affiliation:
University of Michigan
B. A. Thyer
Affiliation:
University of Michigan
*
University of Michigan, Ann Arbor, MI, USA, 48109

Abstract

Twenty non-alcoholic patients with DSM-III defined simple phobias for small animals received behavioural approach tests and exposure therapy while under the influence of a moderately intoxicating dose of ethanol or after placebo administration. Ethanol did not demonstrate any acute anti-anxiety effect, but retarded the rate of behavioural in vivo desensitisation, without changing the final treatment outcome. State-dependent effects of ethanol on anxiety were not demonstrated. This study supports prior research indicating no anti-anxiety or ‘tension-reducing’ effects of ethanol for simple phobias.

Type
Research Article
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Barry, H. & Krimmer, E. C. (1978) Similarities and differences in discriminative stimulus effects of chlordiazepoxide, pentobarbital, ethanol and other sedatives. In Stimulus Properties of Drugs: Ten Years of Progress (eds Colpaert, F. C., Rosecrans, J. H.). New York: Elsevier/North Holland Biomedical Press.Google Scholar
Baum, M. (1969) Paradoxical effect of alcohol on the resistance to extinction of an avoidance response in rats. Journal of Comparative and Physiological Psychology; 69, 238240.CrossRefGoogle ScholarPubMed
Baum, M. (1970) Effect of alcohol on the acquisition and resistance-to-extinction of avoidance responses in rats. Psychological Reports, 26, 759765.CrossRefGoogle ScholarPubMed
Baum, M. (1971) Effect of alcohol on the resistance-to-extinction of an avoidance response: replication with mice. Physiology and Behavior, 6, 307309.Google Scholar
Bernhardt, B. W., Silverstone, T. & Singleton, W. (1980) Behavioural and subjective effects of beta-adrenergic blockade in phobic subjects. British Journal of Psychiatry, 137, 452457.Google Scholar
Bowen, R. C, Cipywnyk, D., D'Arcy, C. & Keegan, D. (1984) Alcoholism, anxiety disorders, and agoraphobia. Alcoholism: Clinical and Experimental Research, 8, 4850.CrossRefGoogle ScholarPubMed
Cappell, H. & Herman, P. (1972) Alcohol and tension reduction: a review. Quarterly Journal of Studies on Alcohol, 33, 3364.Google Scholar
Crow, L. T. & Ball, C. (1975) Alcohol state-dependency and autonomic reactivity. Psychophysiology, 12, 702706.Google Scholar
Curtis, G. C, Nesse, R. M., Buxton, M., Wright, J. & Lippman, D. (1976) Flooding in vivo as a research tool and treatment method of phobias: a preliminary report. Comprehensive Psychiatry, 11, 101107.Google Scholar
Derogatis, L., Lipman, R. & Covi, L. (1973) SCL-90: an out-patient psychiatric rating scale – preliminary report. Psycho-pharmacology Bulletin, 19, 1328.Google Scholar
Goodwin, D. W., Powell, B., Bremer, D., Hoine, H. & Stern, J. (1969) Alcohol and recall: state-dependent effects in man. Science, 163, 13581360.CrossRefGoogle ScholarPubMed
Goodwin, D. W., Powell, B., Bremer, D., Hoine, H. & Guze, S. B. (1979) Psychiatric Diagnosis, 2nd edn. New York: Oxford University Press.Google Scholar
Hafner, R. J. & Marks, I. M. (1976) Exposure in vivo of agoraphobics: contributions of diazepam, group exposure and anxiety evocation. Psychological Medicine, 6, 7188.Google Scholar
Hodgson, R. J., Stockwell, T. R. & Rankin, J. H. (1979) Can alcohol reduce tension? Behaviour Research and Therapy, 17, 459466.CrossRefGoogle ScholarPubMed
Hoffman, F. G. (1983) A Handbook on Drug and Alcohol Abuse: the Biomedical Aspects, 2nd edn. New York: Oxford University Press.Google Scholar
Klein, D. F. (1964) Delineation of two drug-responsive anxiety syndromes. Psychopharmacologia, 5, 397408.Google Scholar
Lipscomb, T. R., Nathan, P. E., Wilson, G. T. & Abrams, D. B. (1980) Effects of tolerance on the anxiety-reducing function of alcohol. Archives of General Psychiatry, 37, 577582.CrossRefGoogle ScholarPubMed
Marks, I. M. (1981) Cure and Care of Neurosis. New York: Wiley.Google Scholar
Marks, I. M. (1985) Behavioral psychotherapy of phobic disorders. In The Psychiatric Clinics of North America: Anxiety Disorders (eds Curtis, G.C., Rainey, J. M., Thyer, B. A.). Philadelphia, PA: Saunders.Google Scholar
Marks, I. M. Viswanathan, R., Lipsedge, M. S. & Gardner, R. (1972) Enhanced relief of phobias by flooding during waning diazepam effect. British Journal of Psychiatry, 121, 493506.CrossRefGoogle ScholarPubMed
Mullaney, J. A. & Trippett, C. J. (1979) Alcohol dependence and phobias: clinical description and relevance. British Journal of Psychiatry, 135, 565573.Google Scholar
Overton, D. H. (1972) State-dependent learning produced by alcohol and its relevance to alcoholism. In The Biology of Alcoholism, Vol. 2: Physiology and behavior (eds Kissin, B., Begleiter, H.). New York: Plenum.Google Scholar
Pohorecky, L. A. (1981) The interaction of alcohol and stress: a review. Neuroscience and Behavioral Reviews, 5, 209229.Google Scholar
Quitkin, F. M., Rifkin, A., Kaplan, J. & Klein, D. F. (1972) Phobic anxiety syndrome complicated by drug dependence and addiction. Archives of General Psychiatry, 27, 159162.Google Scholar
Rimm, D., Briddell, D., Zimmerman, M. & Caddy, G. (1981) The effects of alcohol and the expectancy of alcohol on snake fear. Addictive Behaviors, 6, 4751.CrossRefGoogle ScholarPubMed
Schechter, M. D. (1978) Stimulus properties of ethanol and depressant drugs. In Drug Discrimination and State-Dependent Learning (eds Ho, B. T., Richards, D. W. & Chute, D. L.). New York: Academic Press.Google Scholar
Skurdal, A. J., Eckardt, M. J. & Brown, J. S. (1975) The effects of alcohcol on escape learning and on regular and punished extinction in a self-punitive situation with rats. Physiological Psychology, 3, 2934.Google Scholar
Smail, P., Stockwell, T., Canter, S. & Hodgson, R. (1984) Alcohol dependence and phobic anxiety states – I: A prevalence study. British Journal of Psychiatry, 144, 5357.Google Scholar
Snell, D. & Harris, R. A. (1980) Impairment of avoidance behavior following short-term ingestion of ethanol, tertiary-butanol, or pentobarbital in mice. Psychopharmacology, 69, 5357.CrossRefGoogle ScholarPubMed
Spielberger, C, Gorsuch, R. & Lushene, R. (1970) The State-Trait Anxiety (STAI) Manual for Form X. Palo Alto, CA: Consulting Psychologist's Press.Google Scholar
Stockwell, T., Smail, P., Hodgson, R. & Canter, S. (1984) Alcohol dependence and phobic anxiety states – II: A retrospective study. British Journal of Psychiatry, 144, 5863.Google Scholar
Task Force on Nomenclature and Statistics (1980) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn (DSM-III). Washington, DC: American Psychiatric Press.Google Scholar
Thyer, B. A. & Curtis, G. C. (1984) The effects of ethanol intoxication on phobic anxiety. Behaviour Research and Therapy, 22, 599610.CrossRefGoogle ScholarPubMed
Thyer, B. A. Parrish, R. T., Himle, J., Cameron, O. G., Curtis, G. C. & Nesse, R. M. (1986) Alcohol abuse among clinically anxious patients. Behavior Research and Therapy, 24, 357359.Google Scholar
Weingartner, H., Adefus, W., Eich, J. E. & Murphy, D. L. (1976) Encoding-imagery specificity in alcohol state-dependent learning. Journal of Experimental Psychology: Human Learning and Memory, 2, 8387.Google Scholar
Whitehead, W., Blackwell, B. & Robinson, A. (1978) Effects of diazepam on phobic avoidance behavior and phobic anxiety. Biological Psychiatry, 13, 5964.Google Scholar
Wolpe, J. & Lang, P. (1969) Manual for the Fear Survey Schedule. San Diego, CA: Edits.Google Scholar
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