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Measuring renal function in old age

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  11 August 2004

Indrajit Chattopadhyay
Indrajit Chattopadhyay
Affiliation:
Glan Clwyd Hospital, Rhyl, Denbighshire, UK
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Extract

The kidneys undergo a multitude of structural and functional changes with advancing age. Structurally, there is a progressive loss of predominantly cortical renal mass, a decrease in the number of glomeruli, an increase in the proportion of sclerotic glomeruli, atherosclerotic vascular changes and interstitial changes resulting in atrophy and fibrosis. Functionally, there is a decline in the glomerular filtration rate (GFR), resulting primarily from a decrease in the number of functioning nephrons.

Type
Research Article
Information
Reviews in Clinical Gerontology , Volume 13 , Issue 4 , November 2003 , pp. 297 - 302
Copyright
© 2003 Cambridge University Press

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