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Macronutrients as sources of food energy

Published online by Cambridge University Press:  02 January 2007

Andrew M Prentice
Andrew M Prentice*
Affiliation:
MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK and MRC Keneba, The Gambia
*
*Corresponding author: Email [email protected]
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Abstract

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This background paper considers the extent to which the development of new recommendations for dietary energy requirements needs to account for the macronutrient (fat, carbohydrate, protein and alcohol) profiles of different diets. The issues are discussed from the dual perspectives of avoiding under-nutrition and obesity. It is shown that, in practice, human metabolic processes can adapt to a wide range of fuel supply by altering fuel selection. It is concluded that, at the metabolic level, only diets with the most extreme macronutrient composition would have any consequences by exceeding the natural ability to modify fuel selection. However, diets of different macronutrient composition and energy density can have profound implications for innate appetite regulation and hence overall energy consumption.

Keywords

EnergyMacronutrientsFatCarbohydrateProteinAlcohol
Type
Research Article
Information
Public Health Nutrition , Volume 8 , Issue 7a , October 2005 , pp. 932 - 939
Copyright
Copyright © The Author 2005

References

1FAO/WHO/UNU. Energy and Protein Requirements. Geneva: World Health Organization, 1985.Google Scholar
2FAO. Food Energy – Methods of Analysis and Conversion Factors. Rome: Food and Agriculture Organization, 2002.Google Scholar
3FAO/WHO. Fats and Oils in Human Nutrition. Report of a Joint Expert Consultation. Rome: Food and Agriculture Organization, 1994.Google Scholar
4FAO/WHO. Carbohydrates in Human Nutrition. Report of a Joint Expert Consultation. Rome: Food and Agriculture Organization, 1996.Google Scholar
5Suter, PM, Schutz, Y, Jequier, E. The effect of ethanol on fat storage in healthy subjects. New England Journal of Medicine 1992; 326: 983–7.CrossRefGoogle ScholarPubMed
6Sonko, BJ, Prentice, AM, Murgatroyd, PR, Goldberg, GR, van der Ven, MLH, Coward, WA. Effect of alcohol on post-meal fat storage. American Journal of Clinical Nutrition 1994; 59: 619–25.CrossRefGoogle Scholar
7Prentice, AM. Alcohol and obesity. International Journal of Obesity 1995; 19: S44–50.Google ScholarPubMed
8Lands, WEM, Zakhari, S. The case of the missing calories. American Journal of Clinical Nutrition 1987; 45: 47–8.Google Scholar
9Leiber, CS. Perspectives: do alcohol calories count? American Journal of Clinical Nutrition 1991; 54: 976–82.CrossRefGoogle Scholar
10Westerterp, KR, Prentice, AM, Jequier, E. Alcohol and body weight. In: Macdonald, I, ed. Health Issues Related to Alcohol Consumption. Oxford: Blackwell Science, 1999, 103–23.Google Scholar
11Rolland-Cachera, MF, Deheeger, M, Akrout, M, Bellisle, F. Influence of macronutrients on adiposity development: a follow-up study of nutrition and growth from 10 months to 8 years of age. International Journal of Obesity 1995; 19: 573–8.Google ScholarPubMed
12Dorosty, AR, Emmett, PM, Cowin, SD, Reilly, JJ. Factors associated with early adiposity rebound. ALSPAC Study Team. Pediatrics 2000; 105: 1115–8.CrossRefGoogle ScholarPubMed
13Stubbs, RJ. Macronutrient effects on appetite. International Journal of Obesity 1995; 19(Suppl. 5): S11–9.Google ScholarPubMed
14Skov, A, Toubro, S, Ronn, B, Astrup, A. The effect of a low-fat, high-protein vs. a low-fat, high carbohydrate diet on cardiovascular risk factors in obese subjects. International Journal of Obesity 1996; 20: 47.Google Scholar
15Skov, A, Toubro, S, Ronn, B, Holm, L, Astrup, A. Randomised trial on protein vs carbohydrate in ad libitum fat-reduced diet for treatment of obesity. International Journal of Obesity 1999; 23: 528–36.CrossRefGoogle ScholarPubMed
16Hill, JO, Prentice, AM. Sugar and body weight regulation. American Journal of Clinical Nutrition 1995; 62: 264S–74S.CrossRefGoogle ScholarPubMed
17Bolton-Smith, C, Woodward, M. Dietary composition and fat to sugar ratios in relation to obesity. International Journal of Obesity 1994; 18: 820–8.Google ScholarPubMed
18Ludwig, DS, Peterson, KE, Gortmaker, SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective observational analysis. Lancet 2001; 17: 505–8.CrossRefGoogle Scholar
19Drewnowski, A, Popkin, B. The nutrition transition: New trends in global diet. Nutrition Review 1997; 55: 31–43.CrossRefGoogle ScholarPubMed
20Ferro-Luzzi, A, Sette, S, Franklin, M, James, WP. A simplified approach to assessing adult chronic energy deficiency. European Journal of Clinical Nutrition 1992; 46: 173–86.Google ScholarPubMed
21Prentice, AM. Are all calories equal? In: Cottrell, R, ed. Weight Control: The Current Perspective. London: Chapman & Hall, 1995, 8–33.CrossRefGoogle Scholar
22McNeill, G, Morrison, DC, Davidson, L, Smith, JS. The effect of changes in dietary carbohydrate v. fat intake on 24-h energy expenditure and nutrient oxidation in post-menopausal women. Proceedings of the Nutrition Society 1992; 51: 91A.Google Scholar
23Prentice, AM. Manipulation of dietary fat and energy density: effect on substrate flux and food intake. American Journal of Clinical Nutrition 1998; 67(Suppl.): 535S–41S.CrossRefGoogle ScholarPubMed
24Schutz, Y, Flatt, JP, Jequier, E. Failure of dietary fat intake to promote fat oxidation: a factor favouring the development of obesity. American Journal of Clinical Nutrition 1989; 50: 307–14.CrossRefGoogle ScholarPubMed
25Shetty, PS, Prentice, AM, Goldberg, GR, Murgatroyd, PR, McKenna, APM, Stubbs, RJ, Volschenk, PA. Alterations in fuel selection and voluntary food intake in response to isoenergetic manipulation of glycogen stores in humans. American Journal of Clinical Nutrition 1994; 60: 534–43.CrossRefGoogle ScholarPubMed
26Stubbs, RJ, Murgatoyd, PR, Goldberg, GR, Prentice, AM. Carbohydrate balance and the regulation of day-to-day food intake in humans. American Journal of Clinical Nutrition 1993; 57: 897–903.CrossRefGoogle ScholarPubMed
27Thomas, CD, Peters, JC, Reed, GW, Abumrad, NN, Sun, M, Hill, JO. Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. American Journal of Clinical Nutrition 1992; 55: 934–42.CrossRefGoogle ScholarPubMed
28Jebb, SA, Prentice, AM, Goldberg, GR, Murgatroyd, PR, Black, AE, Coward, WA. Changes in macronutrient balance during over- and under-nutrition assessed by 12-d continuous whole-body calorimetry. American Journal of Clinical Nutrition 1996; 64: 259–66.CrossRefGoogle Scholar
29Schutz, Y, Acheson, KJ, Jequier, E. Twenty-four hour energy expenditure and thermogenesis: response to progressive carbohydrate overfeeding in man. International Journal of Obesity 1984; 9: 111–4.Google Scholar
30Hellerstein, MK, Christiansen, M, Kaempler, S, Kletke, C, Wu, K, Reid, JS, Mulligan, K, Hellerstein, NS, Shackleton, CH. Measurement of de novo hepatic lipogensis in humans using stable isotopes. Journal of Clinical Investigation 1991; 87: 1841–52.CrossRefGoogle Scholar
31Blaxter, K. Energy Metabolism in Animals and Man. Cambridge: Cambridge University Press, 1989.Google Scholar
32Flatt, J-P. The difference in storage capacities for carbohydrate and for fat and its implications for the regulation of body weight. Annals of the New York Academy of Sciences 1987; 499: 104–23.CrossRefGoogle ScholarPubMed
33Flatt, J-P. Importance of nutrient balance in body weight regulation. Diabetes 1988; 4: 571–81.Google ScholarPubMed
34Prentice, AM. Substrate balance and dietary intake: clinical relevance of the glycogenostatic theory. In: Guy-Grand, B, Ailhaud, G, eds. Progress in Obesity Research 8. London: John Wiley, 1999, 453–8.Google Scholar
35Blundell, JE, MacDiarmid, JI. Fat as a risk factor for overconsumption: satiation, satiety and patterns of eating. Journal of American Dietetic Association 1997; 97: S63–9.CrossRefGoogle ScholarPubMed
36Stubbs, RJ, Harbron, CG, Murgatroyd, PR, Prentice, AM. Covert manipulation of dietary fat and energy density: effect on substrate flux and food intake in men eating ad libitum. American Journal of Clinical Nutrition 1995; 62: 316–29.CrossRefGoogle ScholarPubMed
37Kendall, A, Levitsky, DA, Strupp, BJ, Lissner, L. Weight-loss on a low fat diet: consequence of the imprecision of the control of food intake in humans. American Journal of Clinical Nutrition 1991; 53: 1124–9.CrossRefGoogle ScholarPubMed
38Lissner, L, Levitsky, DA, Strupp, BJ, Kalkwarf, HJ, Roe, DA. Dietary fat and regulation of energy intake in human subjects. American Journal of Clinical Nutrition 1987; 46: 886–92.CrossRefGoogle ScholarPubMed
39Stubbs, RJ, Harbron, CG, Prentice, AM. Covert manipulation of the dietary fat to carbohydrate ratio of isoenergentically dense diets: effect on food intake in feed men ad libitum. International Journal of Obesity 1996; 20: 651–60.Google Scholar
40van Stratum, P, Lussenburg, RN, van Wezel, LA, Vergroesen, AJ, Cremer, HD. The effect of dietary carbohydrate: fat ratio on energy intake by adult women. American Journal of Clinical Nutrition 1978; 31: 206–12.CrossRefGoogle ScholarPubMed
41Poppitt, SD, Prentice, AM. Energy density and its role in the control of food intake: Evidence from metabolic and community studies. Appetite 1996; 26: 153–74.CrossRefGoogle ScholarPubMed
42Prentice, AM, Poppitt, SD. Importance of energy density and macronutrients in the regulation of energy intake. International Journal of Obesity 1996; 20(Suppl. 2): S18–23.Google ScholarPubMed
43Stubbs, RJ, Johnstone, AM, O'Reilly, LM, Barton, K, Reid, C. The effect of covertly manipulating the energy density of mixed diets on ad libitum food intake in ‘pseudo free-living’ humans. International Journal of Obesity 1998; 22: 980–7.CrossRefGoogle ScholarPubMed
44Blundell, J, Burley, V, Cotton, J, Delargy, H, Green, S, Greenough, A, King, N, Lawton, C. The fat paradox: fat-induced satiety signals but overconsumption on high fat foods. International Journal of Obesity 1995; 19: 832–5.Google Scholar
45Lissner, L, Heitmann, BL. Dietary fat and obesity: evidence from epidemiology. European Journal of Clinical Nutrition 1995; 49: 79–90.Google ScholarPubMed
46Dreon, DM, Frey-Hewitt, R, Ellsworth, N, Williams, PT, Terry, RB, Wood, PD. Dietary fat: carbohydrate ratio and obesity in middle-aged men. American Journal of Clinical Nutrition 1988; 47: 995–1000.CrossRefGoogle ScholarPubMed
47Heini, AF, Weinsier, RL. Divergent trends in obesity and fat intake patterns: the American paradox. American Journal of Medicine 1997; 102: 259–64.CrossRefGoogle ScholarPubMed
48Astrup, A. The American paradox: the role of energy-dense fat-reduced food in increasing prevalence of obesity. Current Opinion in Clinical Nutrition and Metabolic Care 1998; 1: 573–7.CrossRefGoogle ScholarPubMed
49Astrup, A, Grunwald, GK, Melanson, EL, Saris, WH, Hill, JO. The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies. International Journal of Obesity 2000; 24: 1545–52.CrossRefGoogle ScholarPubMed
50Bray, GA, Popkin, BA. Dietary fat intake does affect obesity. American Journal of Clinical Nutrition 1998; 68: 1157–73.CrossRefGoogle ScholarPubMed
51Katan, MB, Grundy, SM, Willett, WC. Should low-fat, high-carbohydrate diet be recommended for everyone? Beyond low-fat diets. New England Journal of Medicine 1997; 337: 563–6.Google ScholarPubMed
52Cox, D, Mela, DJ. Determination of energy density of freely selected diets: methodological issues and implications. International Journal of Obesity 2000; 24: 49–54.CrossRefGoogle ScholarPubMed
53Drewnowski, A, Holden-Wiltse, J. Taste responses and food preferences in obese women: effects of weight cycling. International Journal of Obesity 1992; 16: 639–72.Google ScholarPubMed
54Mela, DJ. Fat and sugar substitutes: implications for dietary intake and energy balance. Proceedings of the Nutrition Society 1997; 56: 827–40.CrossRefGoogle ScholarPubMed