Sleep-related vehicle accidents are prevalent early morning, especially in younger drivers. In two independent studies following a night of either restricted or nil sleep, young experienced drivers drove for 2 hr (0600–0800h) continuously in an immobile car on an interactive, computer-generated, dull, and monotonous roadway. This exercise followed ingestion (at 0530h) of 200 mg caffeine (= 2–3 cups coffee) versus placebo, counterbalanced, double blind. Driving incidents (lane drifting), subjective sleepiness, and 4–11 Hz electroencephalogram (EEG) activity were logged. In Study 1 (sleeping 0000–0500h), caffeine significantly reduced incidents and subjective sleepiness throughout the 2-hr drive, and EEG power for the second 30-min period. In Study 2 (no sleep), sleepiness affected all measures profoundly, and driving was terminated after 1 hr. Nevertheless, caffeine reduced incidents significantly for the first 30 min and subjective sleepiness for the hour. This caffeine dose, feasibly taken via coffee, effectively reduces early morning driver sleepiness for about 30 min following nil sleep, and for around 2 hr after sleep restriction.

M.E. Smith (1993) obtained event-related brain potentials (ERPs) from subjects performing a recognition memory task using “remember” (R) and “know” (K) judgments, and reported observing in the ERP a “neurophysiological manifestation of recollective experience” as a difference between the positive waveforms elicited by stimuli that yielded R and K judgments. We replicated his experiment and examined the componential structure of the R>K effect in two ways. First, we found that correction for P300 latency jitter eliminated the effect reported by Smith. Second, the application of principal component analysis indicated that the positive waveform elicited by the words in the test list was a P300. These analyses do not support the hypothesis that there is a new component (the “memory-evoked shift”) that is a specific manifestation of recollection.

Electrophysiological effects of aerobic fitness and maximal aerobic exercise were investigated by comparing P300 and N400 before and after a maximal cycling test. Event-related potentials (ERPs) were obtained from 20 students divided into two matched groups defined by their aerobic fitness level (cyclists vs. sedentary subjects). The session of postexercise ERPs was performed immediately after body temperature and heart rate returned to preexercise values. At rest, no significant differences were observed in ERP parameters between cyclists and sedentary subjects. This finding argued against the hypothesis that ERP modifications may be directly assumed by aerobic fitness level. The postexercise session of ERPs showed a significant P300 amplitude increase and a significant P300 latency decrease in all subjects. Similarly, N400 effect increased significantly after the maximal exercise in all subjects. ERP changes were of the same magnitude in the two groups. The present study argues for a general arousing effect of maximal aerobic exercise, independently of the aerobic fitness level.

The present study used the picture perception paradigm to examine the extent to which three well-documented psychophysiological measures demonstrate consistency across time in response to emotional stimuli. The three measures were the eye-blink startle response and the activation in two facial muscle regions (zygomatic and corrugator). Twenty-seven young women were assessed on two occasions, 2 weeks apart. Whereas activation in the corrugator and zygomatic muscle regions demonstrated the predicted patterns at both assessments (with some attenuation in the zygomatic muscle regions), the startle response had limited consistency across the two assessments. The startle response revealed the predicted linear pattern of valence modulation during the first assessment. During the second assessment, startle magnitude response was a quadratic function of valence ratings and a linear function of arousal ratings. The unexpected pattern of startle response during the second session appeared to be related to the content of the pleasant slides, with action slides generating quadratic valence modulation and erotic slides continuing to exhibit the expected linear valence modulation.

In the present study, we examined the stability of one measure of emotion, the emotion-modulated acoustic startle response, in an undergraduate sample. Using the acoustic startle paradigm on two different occasions, we measured stability of affective modulation of the startle response during and following the presentation of pictures selected to be of positive, negative, or neutral emotional valence. The two assessments were separated by 4 weeks. Two groups of subjects were compared: one group that viewed the same pictures at each assessment and a second group that viewed different pictures at the second assessment. We found that viewing different pictures at two assessments separated by 4 weeks yielded moderate stability of the emotion modulation of startle magnitude, whereas subjects who viewed the same pictures at both assessments showed poor stability. Furthermore, this difference was due to the stability of responses to high versus low arousal pictures, not to differences in valence.

Attention has been shown to modulate the amplitude of the mismatch negativity (MMN) elicited by a small deviation in auditory stimuli in adults. The present study examined the effects of attention and deviant size on MMN amplitude in children. Children and adults were presented with sequences of tones containing standards (1000 Hz) and three deviants varying in degree of deviance from the standard (1050, 1200, and 1500 Hz). Tones were presented in three conditions: (1) while participants ignored them; (2) while participants listened to them and responded to all three deviants; and (3) while participants again ignored them. We found that the MMNs elicited by the hard deviant (1050 Hz) were larger when the children were actively discriminating the stimuli than when they were ignoring them. However, the MMNs elicited by the easy and medium deviants (1500 and 1200 Hz, respectively) in the children and by all three deviants in the adults were not affected by attention.

Two experiments assessed the preparatory effects of advance information about response force and movement direction on the lateralized readiness potential (LRP). In a choice reaction time (RT) task, an imperative stimulus required an isometric flexion or an extension of the left or right index finger. Prior information about response force or about movement direction reduced RT and shortened the interval from the onset of the imperative stimulus up to the onset of the LRP. Advance information, however, about direction but not about force decreased the interval from LRP onset to the onset of the overt response. The identical pattern of results was obtained in a second experiment, in which each participant performed both precue conditions. The findings of both experiments support the notion that response force is specified before movement direction. These results are consistent with the view accordingly different mechanisms are involved in the specification of muscle force and movement direction.

Previous research on asymmetric effects of emotional expression and brain-hemispheric asymmetry has supported opposing theories of hemispheric dominance in the control of emotional reactions. In the present study, 32 subjects were exposed to pictures of happy and angry facial stimuli while facial electromyographic (EMG) activity from the zygomatic major and the corrugator supercilii muscle regions was detected from the left and right sides of the face. The subjects reacted spontaneously and rapidly with larger zygomatic EMG activity to happy facial stimuli and larger corrugator EMG activity to angry stimuli. These distinct reactions were significantly larger on the left side of the face. It is concluded that the present results support the hypothesis that the right brain hemisphere is predominantly involved in the control of spontaneously evoked emotional reactions.

Event-related potentials were recorded to investigate the mechanisms of hierarchical processing and level-repetition effect. Participants identified targets that appeared at global, local, or both levels of hierarchical patterns. Reaction times showed global precedence and level-repetition effects. An occipital P1 wave was enhanced to local relative to global targets. The P1 to local targets was also larger when preceded by global than local targets. Global and both-level target selections were indexed by two posterior negativities peaking at 130 and 190 ms poststimulus, whereas local target selection was indexed by a broad occipitotemporal negativity. A late selection positivity was observed over the left occipitotemporal site for global targets but over the central site for local targets. The findings suggest that sensory-perceptual mechanisms contribute to global precedence and level-repetition effects in hierarchical processing.

The prediction that orienting response (OR) reinstatement is negatively related to the measure of common features, shared by the stimulus input and representations of preceding events, and positively related to the measure of their distinctive features, was examined. A nonsignificant test stimulus (TS) was presented after nine repetitions of a standard stimulus (SS), followed by two additional repetitions of SS. TS was created by either substituting 0, 1, or 2 components of SS (Experiment 1), or by either adding or deleting 0, 1, or 2 components of SS (Experiment 2). Skin conductance changes to TS (OR reinstatement) and the subsequent SS (dishabituation) were used as dependent measures. The results of Experiment 1 supported the prediction that substituting components of neutral stimuli affects OR reinstatement, with a larger effect for between-categories than within-categories substitution. Experiment 2 demonstrated that adding and deleting components similarly affects OR reinstatement.

Many physiological changes that occur contemporaneously with nausea are mediated by the autonomic nervous system, but the specific autonomic changes associated with nausea have not been characterized. Cardiac parasympathetic (vagal) activity as indicated by heart rate variability, measured as the standard deviation of successive differences (SDSD) in beat-to-beat intervals, was assessed in 24 women with ovarian cancer immediately prior to and accompanying nausea that occurred following anticancer chemotherapy. A progressive increase in SDSD followed infusion of the chemotherapy agent, indicating a rise in cardiac parasympathetic (vagal) activity, with onset of nausea consistently occurring after the peak activity had been reached, at a time when SDSD was decreasing. An increase in parasympathetic activity seems to set the stage for the expression of nausea but an additional stimulus is apparently needed to finally trigger the event.

Recent studies have shown that the late positive component of the event-related-potential (ERP) is enhanced for emotional pictures, presented in an oddball paradigm, evaluated as distant from an established affective context. In other research, with context-free, random presentation, affectively intense pictures (pleasant and unpleasant) prompted similar enhanced ERP late positivity (compared with the neutral picture response). In an effort to reconcile interpretations of the late positive potential (LPP), ERPs to randomly ordered pictures were assessed, but using the faster presentation rate, brief exposure (1.5 s), and distinct sequences of six pictures, as in studies using an oddball based on evaluative distance. Again, results showed larger LPPs to pleasant and unpleasant pictures, compared with neutral pictures. Furthermore, affective pictures of high arousal elicited larger LPPs than less affectively intense pictures. The data support the view that late positivity to affective pictures is modulated both by their intrinsic motivational significance and the evaluative context of picture presentation.

The aim of the present study was to investigate the modulations in amplitude of H reflexes elicited in a hand muscle, the flexor pollicis brevis, during the performance of a choice reaction time (RT) task in which this muscle was directly involved. Ten subjects were to choose between a left- or a right-thumb key-press according to the lateral location of a flash of light. The stimulus–response mapping was either compatible or incompatible. Hoffman reflexes were elicited at different times during the RT by stimulation of the median nerve. Twenty-five milliseconds before the voluntary response, the amplitude of the H reflex suddenly increased when the muscle was involved in the response and decreased symmetrically when the muscle was not involved in the response. Mapping compatibility exerted no detectable influence on the changes in spinal excitability. The latter result supports the assumptions that are at the core of Sternberg's additive factor method.

Although the generality of dyslexia and its devastating effects on the individual's life are widely acknowledged, its precursors and associated neural mechanisms are poorly understood. One of the two major competing views maintains that dyslexia is based primarily on a deficit in linguistic processing, whereas the other view suggests a more general processing deficit, one involving the perception of temporal information. Here we present evidence in favor of the latter view by showing that the neural discrimination of temporal information within complex tone patterns fails in dyslexic adults. This failure can be traced to early cortical mechanisms that process auditory information independently of attention.

In this study, we examined changes in the event-related potential (ERP) to stimuli with and without reproductive significance occurring during the menstrual cycle. Eleven spontaneously cycling women were tested during three menstrual phases (menses, ovulatory phase, luteal phase) differing in plasma concentrations of gonadal hormones. ERPs were recorded while subjects were presented with slides showing pictures from four different stimulus categories (sexual stimuli, babies, people occupied with body care, ordinary people). Slides were presented randomly in the context of two tasks, requiring either affective processing (i.e., to judge the emotional content of a slide as positive, neutral, or negative) or structural processing (i.e., to estimate the number of parallel thin lines inserted in each picture). Menstrual phase primarily affected a late positive component (LPC) peaking 550–600 ms poststimulus. The effects were as follows: (i) During the ovulatory phase, amplitude of the LPC to sexual stimuli was larger than that evoked by the other stimulus categories. (ii) This relationship was not apparent during the other menstrual phases or (iii) during the ovulatory phase when the task required structural processing. The ovulatory increase in LPC positivity to sexual stimuli suggests a greater valence of these stimuli during a phase of increased sexual desire. The data indicate a specific effect of the menstrual cycle on the processing of sexual stimuli that increases with deeper emotional processing.

Event-related potential (ERP) evidence for the existence of cross-modal links in endogenous spatial attention between vision and touch was obtained in an experiment where participants had to detect tactile or visual targets on the attended side and to ignore the irrelevant modality and stimuli on the unattended side. For visual ERPs, attentional modulations of occipital P1 and N1 components were present when attention was directed both within vision and within touch, indicating that links in spatial attention from touch to vision can affect early stages of visual processing. For somatosensory ERPs, attentional negativities starting around 140 ms poststimulus were present at midline and lateral central electrodes when touch was relevant. No attentional somatosensory ERP modulations were present when vision was relevant and tactile stimuli could be entirely ignored. However, in another task condition where responses were also required to infrequent tactile targets regardless of their location, visual-spatial attention modulated somatosensory ERPs. Unlike vision, touch apparently can be decoupled from attentional orienting within another modality unless it is potentially relevant.

This study investigated the relationship between resistive load magnitude, load magnitude estimation, and the respiratory-related evoked potential. In Part 1, 10 healthy subjects estimated the magnitude of five inspiratory resistive loads. Two subjects were shown to have a markedly reduced slope of the magnitude estimation-resistive load relationship and were suggested to be “poor perceivers” of respiratory stimuli. In Part 2, evoked potentials were recorded from the same 10 subjects using the same resistive loads as Part 1. A log-log plot of the group averaged P1 amplitudes showed a linear relationship with resistive load. Aberrant P3 components were seen in the 2 poor perceiving subjects and one of the 2 showed no late response. In the other 8 subjects, P3 varied as a function of resistive load, being augmented to larger loads. These results provide evidence that P3 may be a key index of the perception of respiratory sensitivity and effort.

Despite the prominence of emotional dysfunction in psychopathology, relatively few experiments have explicitly studied emotion regulation in adults. The present study examined one type of emotion regulation: voluntary regulation of short-term emotional responses to unpleasant visual stimuli. In a sample of 48 college students, both eyeblink startle magnitude and corrugator activity were sensitive to experimental manipulation. Instructions to suppress negative emotion led to both smaller startle eyeblinks and decreased corrugator activity. Instructions to enhance negative emotion led to larger startle eyeblinks and increased corrugator activity. Several advantages of this experimental manipulation are discussed, including the use of both a suppress and an enhance emotion condition, independent measurement of initial emotion elicitation and subsequent regulation of that emotion, the use of a completely within-subjects design, and the use of naturalistic emotion regulation strategies.

In two previous experiments, we studied how stimulus motion affects both the self-report of emotion experience and the physiological sequelae of emotion. In both studies, image motion intensified emotional responding, and the effect of motion was relatively specific to the arousal dimension of the emotion; there was little evidence that image motion altered the valence of the image. Moving images also appeared to sustain the attention of the participants for a longer period of time than did the still images. In these two experiments, however, image motion was manipulated within participants. In the present experiment, we used a between-subjects manipulation of image motion and found a nearly identical pattern of results. These data indicate that motion inherently increments the arousal value of an image and that this increment is not dependent on the context in which motion is introduced.

With the advent of dense sensor arrays (64–256 channels) in electroencephalography and magnetoencephalography studies, the probability increases that some recording channels are contaminated by artifact. If all channels are required to be artifact free, the number of acceptable trials may be unacceptably low. Precise artifact screening is necessary for accurate spatial mapping, for current density measures, for source analysis, and for accurate temporal analysis based on single-trial methods. Precise screening presents a number of problems given the large datasets. We propose a procedure for statistical correction of artifacts in dense array studies (SCADS), which (1) detects individual channel artifacts using the recording reference, (2) detects global artifacts using the average reference, (3) replaces artifact-contaminated sensors with spherical interpolation statistically weighted on the basis of all sensors, and (4) computes the variance of the signal across trials to document the stability of the averaged waveform. Examples from 128-channel recordings and from numerical simulations illustrate the importance of careful artifact review in the avoidance of analysis errors.