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Transdiagnostic and disorder-specific models of intergenerational transmission of internalizing pathology

Published online by Cambridge University Press:  13 May 2013

L. R. Starr ,
C. C. Conway ,
C. L. Hammen  and
P. A. Brennan
L. R. Starr*
Affiliation:
University of California, Los Angeles, CA, USA
C. C. Conway
Affiliation:
University of California, Los Angeles, CA, USA
C. L. Hammen
Affiliation:
University of California, Los Angeles, CA, USA
P. A. Brennan
Affiliation:
Emory University, Atlanta, GA, USA
*
* Address for correspondence: L. R. Starr, Ph.D., Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA. (Email: [email protected])
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Abstract

Background

Numerous studies have supported an association between maternal depression and child psychiatric outcomes, but few have controlled for the confounding effects of both maternal and offspring co-morbidity. Thus, it remains unclear whether the correspondence between maternal and offspring depressive and anxiety disorders is better explained by associations between shared features of maternal and offspring internalizing disorders or by specific effects exerted by unique aspects of individual disorders.

Method

Pairs of mothers and offspring overselected for maternal depression (n = 815) were assessed at offspring age 15 years for anxiety and depressive disorders; 705 completed a follow-up at offspring age 20 years. For both mothers and offspring, structural equation modeling was used to distinguish transdiagnostic internalizing pathology – representing the overlap among all depressive and anxiety disorders – from diagnosis-specific forms of pathology. To discriminate between general versus specific pathways of intergenerational transmission of psychopathology, we examined (a) the general association between the maternal and offspring internalizing factors and (b) the correlations between maternal and offspring diagnosis-specific pathology for each disorder.

Results

For mothers and offspring, a unidimensional latent variable model provided the best fit to the correlations among depressive and anxiety disorders. The maternal transdiagnostic internalizing factor strongly predicted the corresponding factor among offspring. In addition, the unique component of post-traumatic stress disorder among offspring was significantly related to the analogous unique component among mothers, but specific components of other maternal disorders, including depression, did not predict corresponding offspring pathology.

Conclusions

Results suggest that intergenerational transmission of internalizing disorders is largely non-specific.

Keywords

Intergenerational transmissioninternalizing disordersmaternal anxiety disordersmaternal depression
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 1 , January 2014 , pp. 161 - 172
Copyright
Copyright © Cambridge University Press 2013 

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References

APA (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn, revised. American Psychological Association: Washington, DC.Google Scholar
Bedford, A, Foulds, G (1978). Delusions-Symptoms-States Inventory of Anxiety and Depression. NFER: Windsor.Google Scholar
Bentler, PM (1990). Comparative fit indexes in structural models. Psychological Bulletin 107, 238–246.CrossRefGoogle ScholarPubMed
Billings, AG, Moos, R (1985). Children of parents with unipolar depression: a controlled 1-year follow-up. Journal of Abnormal Child Psychology 14, 149–166.CrossRefGoogle Scholar
Brand, SR, Schechter, JC, Hammen, CL, Brocque, RL, Brennan, PA (2011). Do adolescent offspring of women with PTSD experience higher levels of chronic and episodic stress? Journal of Traumatic Stress 24, 399–404.CrossRefGoogle ScholarPubMed
Brennan, PA, Hammen, C, Katz, AR, Le Brocque, RM (2002). Maternal depression, paternal psychopathology, and adolescent diagnostic outcomes. Journal of Consulting and Clinical Psychology 70, 1075–1085.CrossRefGoogle ScholarPubMed
Brown, TA, Barlow, DH (2002). Classification of anxiety and mood disorders. In Anxiety and its Disorders: The Nature and Treatment of Anxiety and Panic (ed. Barlow, D. H.), pp. 292–327. Guilford Press: New York.Google Scholar
Browne, MW, Cudeck, R (1993). Alternative ways of assessing model fit. In Testing Structural Equation Models (ed. Bollen, K. A. and Long, J. S.), pp. 136–162. Sage: Newbury Park, CA.Google Scholar
Burt, KB, Van Dulmen, MHM, Carlivati, J, Egeland, B, Alan Sroufe, L, Forman, DR, Appleyard, K, Carlson, EA (2005). Mediating links between maternal depression and offspring psychopathology: the importance of independent data. Journal of Child Psychology and Psychiatry 46, 490–499.CrossRefGoogle ScholarPubMed
Conway, CC, Hammen, C, Brennan, PA (2012). Expanding stress generation theory: test of a transdiagnostic model. Journal of Abnormal Psychology 121, 754–766.CrossRefGoogle ScholarPubMed
Corley, RP, Zeiger, JS, Crowley, T, Ehringer, MA, Hewitt, JK, Hopfer, CJ, Lessem, J, McQueen, MB, Rhee, SH, Smolen, A, Stallings, MC, Young, SE, Krauter, K (2008). Association of candidate genes with antisocial drug dependence in adolescents. Drug and Alcohol Dependence 96, 90–98.CrossRefGoogle ScholarPubMed
Cox, AD, Puckering, C, Pound, A, Mills, M (1987). The impact of maternal depression in young children. Journal of Child Psychology and Psychiatry 28, 917–928.CrossRefGoogle ScholarPubMed
Cox, BJ, Clara, IP, Enns, MW (2002). Posttraumatic stress disorder and the structure of common mental disorders. Depression and Anxiety 15, 168–171.CrossRefGoogle ScholarPubMed
Craske, MG, Wolitzky-Taylor, KB, Mineka, S, Zinbarg, R, Waters, AM, Vrshek-Schalihorn, S, Epstein, A, Naliboff, B, Ornitz, E (2012). Elevated responding to safe conditions as a specific risk factor for anxiety versus depressive disorders: evidence from a longitudinal investigation. Journal of Abnormal Psychology 121, 315–324.CrossRefGoogle ScholarPubMed
Delahanty, DL, Raimonde, AJ, Spoonster, E, Cullado, M (2003). Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims. Journal of Anxiety Disorders 17, 149–164.CrossRefGoogle ScholarPubMed
Dick, DM, Aliev, F, Wang, JC, Grucza, RA, Schuckit, M, Kuperman, S, Kramer, J, Hinrichs, A, Bertelsen, S, Budde, JP (2008). Using dimensional models of externalizing psychopathology to aid in gene identification. Archives of General Psychiatry 65, 310.CrossRefGoogle ScholarPubMed
Eaton, DK, Kann, L, Kinchen, S, Shanklin, S, Flint, KH, Hawkins, J, Harris, WA, Lowry, R, McManus, T, Chyen, D, Whittle, L, Lim, C, Wechsler, H (2012). Youth risk behavior surveillance – United States, 2011. Morbidity and Mortality Weekly Report . Surveillance Summaries 61, 1– 162.Google Scholar
Eaton, NR, Krueger, RF, Markon, KE, Keyes, KM, Skodol, AE, Wall, M, Hasin, DS, Grant, BF (2013). The structure and predictive validity of the internalizing disorders. Journal of Abnormal Psychology 122, 86–92.CrossRefGoogle ScholarPubMed
Elgar, FJ, McGrath, PJ, Waschbusch, DA, Stewart, SH, Curtis, LJ (2004). Mutual influences on maternal depression and child adjustment problems. Clinical Psychology Review 24, 441–459.CrossRefGoogle ScholarPubMed
Fergusson, DM, Horwood, LJ, Boden, JM (2006). Structure of internalising symptoms in early adulthood. British Journal of Psychiatry 189, 540–546.CrossRefGoogle ScholarPubMed
Goodman, SH, Gotlib, IH (1999). Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission. Psychological Review 106, 458–490.CrossRefGoogle ScholarPubMed
Goodman, SH, Rouse, MH, Connell, AM, Broth, MR, Hall, CM, Heyward, D (2011). Maternal depression and child psychopathology: a meta-analytic review. Clinical Child and Family Psychology Review 14, 1–27.CrossRefGoogle ScholarPubMed
Griffith, JW, Zinbarg, RE, Craske, MG, Mineka, S, Rose, RD, Waters, AM, Sutton, JM (2010). Neuroticism as a common dimension in the internalizing disorders. Psychological Medicine 40, 1125–1136.CrossRefGoogle ScholarPubMed
Halligan, SL, Murray, L, Martins, C, Cooper, PJ (2007). Maternal depression and psychiatric outcomes in adolescent offspring: a 13-year longitudinal study. Journal of Affective Disorders 97, 145–154.CrossRefGoogle ScholarPubMed
Hammen, C, Brennan, P, Keenan-Miller, D (2008). Patterns of adolescent depression to age 20: the role of maternal depression and youth interpersonal dysfunction. Journal of Abnormal Child Psychology 36, 1189–1198.CrossRefGoogle ScholarPubMed
Hammen, C, Brennan, PA (2001). Depressed adolescents of depressed and nondepressed mothers: tests of an interpersonal impairment hypothesis. Journal of Consulting and Clinical Psychology 69, 284–294.CrossRefGoogle ScholarPubMed
Hammen, C, Burge, D, Burney, E, Adrian, C (1990). Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder. Archives of General Psychiatry 47, 1112–1117.CrossRefGoogle ScholarPubMed
Hammen, C, Shih, JH, Brennan, PA (2004). Intergenerational transmission of depression: test of an interpersonal stress model in a community sample. Journal of Consulting and Clinical Psychology 72, 511–522.CrossRefGoogle Scholar
Haslam, N, Holland, E, Kuppens, P (2012). Categories versus dimensions in personality and psychopathology: a quantitative review of taxometric research. Psychological Medicine 42, 903–920.CrossRefGoogle ScholarPubMed
Hicks, BM, Krueger, RF, Iacono, WG, McGue, M, Patrick, CJ (2004). Family transmission and heritability of externalizing disorders: a twin-family study. Archives of General Psychiatry 61, 922–928.CrossRefGoogle ScholarPubMed
Kaufman, J, Birmaher, B, Brent, D, Rao, U (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry 36, 980–988.CrossRefGoogle ScholarPubMed
Keeping, JD, Najman, JM, Morrison, J, Western, JS, Anderson, MJ, Williams, GM (1989). A prospective longitudinal study of social, psychological, and obstetrical factors in pregnancy: response rates and demographic characteristics of the 8,556 respondents. British Journal of Obstetrics and Gynaecology 96, 289–297.CrossRefGoogle Scholar
Kendler, KS, Davis, CG, Kessler, RC (1997). The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: a family history study. British Journal of Psychiatry 170, 541–548.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, P, Demler, O, Jin, R, Walters, EE (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey replication. Archives of General Psychiatry 62, 593–602.CrossRefGoogle ScholarPubMed
Klein, DN, Lewinsohn, PM, Rohde, P, Seeley, JR, Olino, TM (2005). Psychopathology in the adolescent and young adult offspring of a community sample of mothers and fathers with major depression. Psychological Medicine 35, 353–365.CrossRefGoogle Scholar
Krueger, RF (1999). The structure of common mental disorders. Archives of General Psychiatry 56, 921–926.CrossRefGoogle ScholarPubMed
Krueger, RF, Caspi, A, Moffitt, TE, Silva, PA (1998). The structure and stability of common mental disorders (DSM-III-R): a longitudinal–epidemiological study. Journal of Abnormal Psychology 107, 216–227.CrossRefGoogle ScholarPubMed
Krueger, RF, Finger, MS (2001). Using item response theory to understand comorbidity among anxiety and unipolar mood disorders. Psychological Assessment 13, 140–151.CrossRefGoogle ScholarPubMed
Krueger, RF, Markon, KE (2006). Reinterpreting comorbidity: a model-based approach to understanding and classifying psychopathology. Annual Review of Clinical Psychology 2, 111–133.CrossRefGoogle ScholarPubMed
Krueger, RF, Markon, KE (2011). A dimensional-spectrum model of psychopathology: progress and opportunities. Archives of General Psychiatry 68, 10–11.CrossRefGoogle ScholarPubMed
Last, CG, Hersen, M, Kazdin, AE, Francis, G, Grubb, HJ (1987). Psychiatric illness in the mothers of anxious children. American Journal of Psychiatry 144, 1580–1583.Google ScholarPubMed
Lewinsohn, PM, Rohde, P, Seely, JR (1998). Major depressive disorder in older adolescents: prevalence, risk factors, and clinical implications. Clinical Psychology Review 18, 765–794.CrossRefGoogle ScholarPubMed
Lieb, R, Isensee, B, Hofler, M, Pfister, H, Wittchen, HU (2002). Parental major depression and the risk of depression and other mental disorders in offspring: a prospective-longitudinal community study. Archives of General Psychiatry 59, 365–374.CrossRefGoogle ScholarPubMed
Markon, KE (2010). Modeling psychopathology structure: a symptom-level analysis of Axis I and II disorders. Psychological Medicine 40, 273–288.CrossRefGoogle ScholarPubMed
McClure, EB, Brennan, PA, Hammen, C, Le Brocque, RM (2001). Parental anxiety disorders, child anxiety disorders, and the perceived parent–child relationship in an Australian high-risk sample. Journal of Abnormal Child Psychology 29, 1–10.CrossRefGoogle Scholar
McLaughlin, KA, Gadermann, AM, Hwang, I, Sampson, NA, Al-Hamzawi, A, Andrade, LH, Angermeyer, MC, Benjet, C, Bromet, EJ, Bruffaerts, R, Caldas-de-Almeida, JM, de Girolamo, G, de Graaf, R, Florescu, S, Gureje, O, Haro, JM, Hinkov, HR, Horiguchi, I, Hu, C, Karam, AN, Kovess-Masfety, V, Lee, S, Murphy, SD, Nizamie, SH, Posada-Villa, J, Williams, DR, Kessler, RC (2012). Parent psychopathology and offspring mental disorders: results from the WHO World Mental Health Surveys. British Journal of Psychiatry 200, 290–299.CrossRefGoogle ScholarPubMed
Merikangas, KR, He, J-P, Burstein, M, Swanson, SA, Avenevoli, S, Cui, L, Benjet, C, Georgiades, K, Swendsen, J (2010). Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A). Journal of the Academy of Child and Adolescent Psychiatry 49, 980–989.CrossRefGoogle ScholarPubMed
Milne, BJ, Caspi, A, Crump, R, Poulton, R, Rutter, M, Sears, MR, Moffitt, TE (2009). The validity of the Family History Screen for assessing family history of mental disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B, 41–49.CrossRefGoogle ScholarPubMed
Muthén, LK, Muthén, BO (1998–2011). Mplus User's Guide, 6th edn. Muthén & Muthén: Los Angeles, CA.Google Scholar
Pettit, JW, Olino, TM, Roberts, RE, Seeley, JR, Lewinsohn, PM (2008). Intergenerational transmission of internalizing problems: effects of parental and grandparental major depressive disorder on child behavior. Journal of Clinical Child and Adolescent Psychology 37, 640–650.CrossRefGoogle ScholarPubMed
Prenoveau, JM, Zinbarg, RE, Craske, MG, Mineka, S, Griffith, JW, Epstein, AM (2010). Testing a hierarchical model of anxiety and depression in adolescents: a tri-level model. Journal of Anxiety Disorders 24, 334–344.CrossRefGoogle ScholarPubMed
Prisciandaro, JJ, Robert, JE (2009). A comparison of the predictive abilities of dimensional and categorical models of unipolar depression in the National Comorbidity Survey. Psychological Medicine 39, 1087–1096.CrossRefGoogle ScholarPubMed
Raison, CL, Miller, AH (2003). When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. American Journal of Psychiatry 160, 1554–1565.CrossRefGoogle ScholarPubMed
Simms, LJ, Grös, DF, Watson, D, O'Hara, MW (2008). Parsing the general and specific components of depression and anxiety with bifactor modeling. Depression and Anxiety 25, E34–E46.CrossRefGoogle ScholarPubMed
Simms, LJ, Prisciandaro, JJ, Krueger, RF, Goldberg, DP (2012). The structure of depression, anxiety and somatic symptoms in primary care. Psychological Medicine 42, 15–28.CrossRefGoogle ScholarPubMed
Slade, T, Watson, D (2006). The structure of common DSM-IV and ICD-10 mental disorders in the Australian general population. Psychological Medicine 36, 1593–1600.CrossRefGoogle ScholarPubMed
South, SC, Krueger, RF, Iacono, WG (2011). Understanding general and specific connections between psychopathology and marital distress: a model based approach. Journal of Abnormal Psychology 120, 935.CrossRefGoogle ScholarPubMed
Spitzer, RL, Williams, JBW, Gibbon, M, First, M (1995). Structured Clinical Interview for DSM-IV (SCID-IV). American Psychiatric Association: Washington, DC.Google Scholar
Tully, EC, Iacono, WG, McGue, M (2008). An adoption study of parental depression as an environmental liability for adolescent depression and childhood disruptive disorders. American Journal of Psychiatry 165, 1148.CrossRefGoogle ScholarPubMed
Turner, SM, Beidel, DC, Costello, A (1987). Psychopathology in the offspring of anxiety disorders patients. Journal of Consulting and Clinical Psychology 55, 229–235.CrossRefGoogle ScholarPubMed
Vollebergh, WAM, Iedema, J, Bijl, RV, de Graaf, R, Smit, F, Ormel, J (2001). The structure and stability of common mental disorders: the NEMESIS study. Archives of General Psychiatry 58, 597.CrossRefGoogle ScholarPubMed
Walton, KE, Ormel, J, Krueger, RF (2011). The dimensional nature of externalizing behaviors in adolescence: evidence from a direct comparison of categorical, dimensional, and hybrid models. Journal of Abnormal Child Psychology 39, 553–561.CrossRefGoogle ScholarPubMed
Warner, V, Weissman, MM, Mufson, L, Wickramaratne, PJ (1999). Grandparents, parents, and grandchildren at high risk for depression: a three-generation study. Journal of the American Academy of Child and Adolescent Psychiatry 38, 289–296.CrossRefGoogle ScholarPubMed
Watson, D (2005). Rethinking the mood and anxiety disorders: a quantitative hierarchical model for DSM-V. Journal of Abnormal Psychology 114, 522–536.CrossRefGoogle ScholarPubMed
Watson, D, Clark, LA, Weber, K, Assenheimer, JS, Strauss, ME, McCormick, RA (1995). Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples. Journal of Abnormal Psychology 104, 15–25.CrossRefGoogle ScholarPubMed
Weissman, MM, Leckman, JF, Merikangas, KR, Gammon, GD, Prusoff, BA (1984). Depression and anxiety disorders in parents and children: results from the Yale family study. Archives of General Psychiatry 41, 845–852.CrossRefGoogle ScholarPubMed
Weissman, MM, Wickramaratne, P, Nomura, Y, Warner, V, Pilowsky, D, Verdeli, H (2006). Offspring of depressed parents: 20 years later. American Journal of Psychiatry 163, 1001–1008.CrossRefGoogle ScholarPubMed
Wright, AGC, Krueger, RF, Hobbs, MJ, Markon, KE, Eaton, NR, Slade, T (2013). The structure of psychopathology: toward an expanded quantitative empirical model. Journal of Abnormal Psychology 122, 281–294.CrossRefGoogle ScholarPubMed
Yehuda, R, Engel, SM, Brand, SR, Seckl, J, Marcus, SM, Berkowitz, GS (2005). Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. Journal of Clinical Endocrinology and Metabolism 90, 4115–4118.CrossRefGoogle Scholar
Yehuda, R, Halligan, SL, Bierer, LM (2001 a). Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring. Journal of Psychiatric Research 35, 261–270.CrossRefGoogle ScholarPubMed
Yehuda, R, Halligan, SL, Grossman, R (2001 b). Childhood trauma and risk for PTSD: relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion. Development and Psychopathology 13, 733–753.CrossRefGoogle ScholarPubMed
Yehuda, R, Teicher, MH, Seckl, JR, Grossman, RA, Morris, A, Bierer, LM (2007). Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors. Archives of General Psychiatry 64, 1040–1048.CrossRefGoogle ScholarPubMed