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Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk

Published online by Cambridge University Press:  16 June 2011

M. Konings ,
N. Stefanis ,
R. Kuepper ,
R. de Graaf ,
M. ten Have ,
J. van Os ,
C. Bakoula  and
C. Henquet
M. Konings
Affiliation:
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, The Netherlands Department of Psychiatry, GGZ Eindhoven, The Netherlands
N. Stefanis
Affiliation:
University of Mental Health Research Institute (UMHRI) and Department of Psychiatry, National and Kapodistrian University of Athens, Greece
R. Kuepper
Affiliation:
Department of Psychiatry, GGZ Eindhoven, The Netherlands
R. de Graaf
Affiliation:
Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
M. ten Have
Affiliation:
Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
J. van Os
Affiliation:
Department of Psychiatry, GGZ Eindhoven, The Netherlands Department of Psychosis Studies, Institute of Psychiatry, King's College London, King's Health Partners, London, UK
C. Bakoula
Affiliation:
First Department of Pediatrics, Athens University Medical School, ‘Aghia Sophia’ Children's Hospital, Athens, Greece
C. Henquet*
Affiliation:
Department of Psychiatry, GGZ Eindhoven, The Netherlands PsyQ Heerlen, Mondriaan, Zuid-Limburg, The Netherlands
*
*Address for correspondence: Dr C. Henquet, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, PO Box 616 (Vijverdal), 6200 MD Maastricht, The Netherlands. (Email: [email protected])
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Abstract

Background

There may be biological plausibility to the notion that cannabis use and childhood trauma or maltreatment synergistically increase the risk for later development of psychotic symptoms. To replicate and further investigate this issue, prospective data from two independent population-based studies, the Greek National Perinatal Study (n=1636) and The Netherlands Mental Health Survey and Incidence Study (NEMESIS) (n=4842), were analyzed.

Method

Two different data sets on cannabis use and childhood maltreatment were used. In a large Greek population-based cohort study, data on cannabis use at age 19 years and childhood maltreatment at 7 years were assessed. In addition, psychotic symptoms were assessed using the Community Assessment of Psychic Experiences (CAPE). In NEMESIS, the Composite International Diagnostic Interview (CIDI) was used to assess psychotic symptoms at three different time points along with childhood maltreatment and lifetime cannabis use.

Results

A significant adjusted interaction between childhood maltreatment and later cannabis use was evident in both samples, indicating that the psychosis-inducing effects of cannabis were stronger in individuals exposed to earlier sexual or physical mistreatment [Greek National Perinatal Study: test for interaction F(2, 1627)=4.18, p=0.02; NEMESIS: test for interaction χ2(3)=8.08, p=0.04].

Conclusions

Cross-sensitivity between childhood maltreatment and cannabis use may exist in pathways that shape the risk for expression of positive psychotic symptoms.

Keywords

Cannabischildhood traumainteractionpsychosisschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 1 , January 2012 , pp. 149 - 159
Copyright
Copyright © Cambridge University Press 2011

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References

Abercrombie, ED, Keefe, KA, DiFrischia, DS, Zigmond, MJ (1989). Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex. Journal of Neurochemistry 52, 1655–1658.CrossRefGoogle ScholarPubMed
Arseneault, L, Cannon, M, Fisher, HL, Polanczyk, G, Moffitt, TE, Caspi, A (2011). Childhood trauma and children's emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. American Journal of Psychiatry 168, 65–72.CrossRefGoogle ScholarPubMed
Bijl, RV, Ravelli, A, van Zessen, G (1998 a). Prevalence of psychiatric disorder in the general population: results of The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Social Psychiatry and Psychiatric Epidemiology 33, 587–595.CrossRefGoogle ScholarPubMed
Bijl, RV, van Zessen, G, Ravelli, A, de Rijk, C, Langendoen, Y (1998 b). The Netherlands Mental Health Survey and Incidence Study (NEMESIS): objectives and design. Social Psychiatry and Psychiatric Epidemiology 33, 581–586.CrossRefGoogle ScholarPubMed
Bossong, MG, van Berckel, BN, Boellaard, R, Zuurman, L, Schuit, RC, Windhorst, AD, van Gerven, JM, Ramsey, NF, Lammertsma, AA, Kahn, RS (2009). Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 34, 759–766.CrossRefGoogle ScholarPubMed
Brenner, K, Schmitz, N, Pawliuk, N, Fathalli, F, Joober, R, Ciampi, A, King, S (2007). Validation of the English and French versions of the Community Assessment of Psychic Experiences (CAPE) with a Montreal community sample. Schizophrenia Research 95, 86–95.CrossRefGoogle ScholarPubMed
Cadoni, C, Pisanu, A, Solinas, M, Acquas, E, Di Chiara, G (2001). Behavioural sensitization after repeated exposure to Delta 9-tetrahydrocannabinol and cross-sensitization with morphine. Psychopharmacology (Berlin) 158, 259–266.CrossRefGoogle ScholarPubMed
Cadoni, C, Valentini, V, Di Chiara, G (2008). Behavioral sensitization to delta 9-tetrahydrocannabinol and cross-sensitization with morphine: differential changes in accumbal shell and core dopamine transmission. Journal of Neurochemistry 106, 1586–1593.CrossRefGoogle ScholarPubMed
Cheer, JF, Wassum, KM, Heien, ML, Phillips, PE, Wightman, RM (2004). Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. Journal of Neuroscience 24, 4393–4400.CrossRefGoogle ScholarPubMed
Clarke, MC, Tanskanen, A, Huttunen, M, Whittaker, JC, Cannon, M (2009). Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia. American Journal of Psychiatry 166, 1025–1030.CrossRefGoogle ScholarPubMed
Collip, D, Myin-Germeys, I, van Os, J (2008). Does the concept of ‘sensitization’ provide a plausible mechanism for the putative link between the environment and schizophrenia? Schizophrenia Bulletin 34, 220–225.CrossRefGoogle ScholarPubMed
Corcoran, C, Malaspina, D (2001). Traumatic brain injury and schizophrenia. International Journal of Mental Health 30, 17–33.CrossRefGoogle Scholar
Cougnard, A, Marcelis, M, Myin-Germeys, I, De Graaf, R, Vollebergh, W, Krabbendam, L, Lieb, R, Wittchen, HU, Henquet, C, Spauwen, J, van Os, J (2007). Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness-persistence model. Psychological Medicine 37, 513–527.CrossRefGoogle ScholarPubMed
Darroch, J (1997). Biologic synergism and parallelism. American Journal of Epidemiology 145, 661–668.CrossRefGoogle ScholarPubMed
Davis, KL, Kahn, RS, Ko, G, Davidson, M (1991). Dopamine in schizophrenia: a review and reconceptualization. American Journal of Psychiatry 148, 1474–1486.Google ScholarPubMed
de Graaf, R, Bijl, RV, Smit, F, Ravelli, A, Vollebergh, WA (2000). Psychiatric and sociodemographic predictors of attrition in a longitudinal study: The Netherlands Mental Health Survey and Incidence Study (NEMESIS). American Journal of Epidemiology 152, 1039–1047.CrossRefGoogle Scholar
Di Forti, M, Morgan, C, Dazzan, P, Pariante, C, Mondelli, V, Marques, TR, Handley, R, Luzi, S, Russo, M, Paparelli, A, Butt, A, Stilo, SA, Wiffen, B, Powell, J, Murray, RM (2009). High-potency cannabis and the risk of psychosis. British Journal of Psychiatry 195, 488–491.CrossRefGoogle ScholarPubMed
Dill, DL, Chu, JA, Grob, MC, Eisen, SV (1991). The reliability of abuse history reports: a comparison of two inquiry formats. Comprehensive Psychiatry 32, 166–169.CrossRefGoogle ScholarPubMed
Dominguez, MD, Wichers, M, Lieb, R, Wittchen, HU, van Os, J (2010). Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study. Schizophrenia Bulletin 37, 84–93.CrossRefGoogle Scholar
D'Souza, DC, Abi-Saab, WM, Madonick, S, Forselius-Bielen, K, Doersch, A, Braley, G, Gueorguieva, R, Cooper, TB, Krystal, JH (2005). Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biological Psychiatry 57, 594–608.CrossRefGoogle ScholarPubMed
Elklit, A, Shevlin, M (2010). Female sexual victimization predicts psychosis: a case-control study based on the Danish Registry System. Schizophrenia Bulletin. Published online: 20 May 2010. doi:10.1093/schbul/sbq048.Google ScholarPubMed
Engert, V, Joober, R, Meaney, MJ, Hellhammer, DH, Pruessner, JC (2009). Behavioral response to methylphenidate challenge: influence of early life parental care. Developmental Psychobiology 51, 408–416.CrossRefGoogle ScholarPubMed
Fergusson, DM, Lynskey, MT (1997). Physical punishment/maltreatment during childhood and adjustment in young adulthood. Child Abuse and Neglect 21, 617–630.CrossRefGoogle ScholarPubMed
Fisher, HL, Jones, PB, Fearon, P, Craig, TK, Dazzan, P, Morgan, K, Hutchinson, G, Doody, GA, McGuffin, P, Leff, J, Murray, RM, Morgan, C (2010). The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychological Medicine 40, 1967–1978.CrossRefGoogle ScholarPubMed
Freeman, D, Fowler, D (2009). Routes to psychotic symptoms: trauma, anxiety and psychosis-like experiences. Psychiatry Research 169, 107–112.CrossRefGoogle ScholarPubMed
French, ED, Dillon, K, Wu, X (1997). Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport 8, 649–652.CrossRefGoogle ScholarPubMed
Glenthoj, BY (1995). The brain dopaminergic system. Pharmacological, behavioural and electrophysiological studies. Danish Medical Bulletin 42, 1–21.Google ScholarPubMed
GROUP (2011). Evidence that familial liability for psychosis is expressed as differential sensitivity to cannabis: an analysis of patient-sibling and sibling-control pairs. Archives of General Psychiatry 68, 138–147.CrossRefGoogle Scholar
Hanssen, M, Bak, M, Bijl, R, Vollebergh, W, van Os, J (2005). The incidence and outcome of subclinical psychotic experiences in the general population. British Journal of Clinical Psychology 44, 181–191.CrossRefGoogle ScholarPubMed
Hanssen, M, Peeters, F, Krabbendam, L, Radstake, S, Verdoux, H, van Os, J (2003). How psychotic are individuals with non-psychotic disorders? Social Psychiatry and Psychiatric Epidemiology 38, 149–154.CrossRefGoogle ScholarPubMed
Harley, M, Kelleher, I, Clarke, M, Lynch, F, Arseneault, L, Connor, D, Fitzpatrick, C, Cannon, M (2010). Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. Psychological Medicine 40, 1627–1634.CrossRefGoogle ScholarPubMed
Henquet, C, Krabbendam, L, de Graaf, R, ten Have, M, van Os, J (2006). Cannabis use and expression of mania in the general population. Journal of Affective Disorders 95, 103–110.CrossRefGoogle ScholarPubMed
Henquet, C, Krabbendam, L, Spauwen, J, Kaplan, C, Lieb, R, Wittchen, HU, van Os, J (2005). Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. British Medical Journal 330, 11.CrossRefGoogle ScholarPubMed
Henquet, C, Di Forti, M, Morrison, P, Kuepper, R, Murray, RM (2008). Gene-environment interplay between cannabis and psychosis. Schizophrenia Bulletin 34, 1111–1121.CrossRefGoogle ScholarPubMed
Henquet, C, van Os, J, Kueper, R, Delespaul, P, Smits, M, Campo, JA, Myin-Germeys, I (2010). Psychosis reactivity to cannabis use in daily life: an experience sampling study. British Journal Psychiatry 196, 447–453.CrossRefGoogle ScholarPubMed
Houston, JE, Murphy, J, Adamson, G, Stringer, M, Shevlin, M (2008). Childhood sexual abuse, early cannabis use, and psychosis: testing an interaction model based on the National Comorbidity Survey. Schizophrenia Bulletin 34, 580–585.CrossRefGoogle ScholarPubMed
Janssen, I, Krabbendam, L, Bak, M, Hanssen, M, Vollebergh, W, de Graaf, R, van Os, J (2004). Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatrica Scandinavica 109, 38–45.CrossRefGoogle ScholarPubMed
Kapur, S (2003). Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry 160, 13–23.CrossRefGoogle ScholarPubMed
Kelleher, I, Harley, M, Lynch, F, Arseneault, L, Fitzpatrick, C, Cannon, M (2008). Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. British Journal of Psychiatry 193, 378–382.CrossRefGoogle ScholarPubMed
Kendler, KS, Karkowski-Shuman, L (1997). Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychological Medicine 27, 539–547.CrossRefGoogle ScholarPubMed
Kendler, KS, Kessler, RC, Walters, EE, MacLean, C, Neale, MC, Heath, AC, Eaves, LJ (1995). Stressful life events, genetic liability, and onset of an episode of major depression in women. American Journal of Psychiatry 152, 833–842.Google ScholarPubMed
Kokkevi, A, Fotiou, A, Richardson, C (2007). Drug use in the general population of Greece over the last 20 years: results from nationwide household surveys. European Addiction Research 13, 167–176.CrossRefGoogle ScholarPubMed
Kokkevi, A, Nic Gabhainn, S, Spyropoulou, M (2006). Early initiation of cannabis use: a cross-national European perspective. Journal of Adolescent Health 39, 712–719.CrossRefGoogle ScholarPubMed
Konings, M, Bak, M, Hanssen, M, van Os, J, Krabbendam, L (2006). Validity and reliability of the CAPE: a self-report instrument for the measurement of psychotic experiences in the general population. Acta Psychiatrica Scandinavica 114, 55–61.CrossRefGoogle Scholar
Konings, M, Maharajh, HD (2006). Cannabis use and mood disorders: patterns of clinical presentations among adolescents in a developing country. International Journal of Adolescent Medicine and Health 18, 221–233.CrossRefGoogle ScholarPubMed
Kuepper, R, Morrison, PD, van Os, J, Murray, RM, Kenis, G, Henquet, C (2010). Does dopamine mediate the psychosis-inducing effects of cannabis? A review and integration of findings across disciplines. Schizophrenia Research 121, 107–117.CrossRefGoogle ScholarPubMed
Laruelle, M (2000). The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies. Brain Research Reviews 31, 371–384.CrossRefGoogle ScholarPubMed
Lataster, T, van Os, J, Drukker, M, Henquet, C, Feron, F, Gunther, N, Myin-Germeys, I (2006). Childhood victimisation and developmental expression of non-clinical delusional ideation and hallucinatory experiences: victimisation and non-clinical psychotic experiences. Social Psychiatry and Psychiatric Epidemiology 41, 423–428.CrossRefGoogle ScholarPubMed
Mackie, CJ, Castellanos-Ryan, N, Conrod, PJ (2010). Developmental trajectories of psychotic-like experiences across adolescence: impact of victimization and substance use. Psychological Medicine 29, 1–12.Google Scholar
MacLean, KI, Littleton, JM (1977). Environmental stress as a factor in the response of rat brain catecholamine metabolism to delta8-tetrahydrocannabinol. European Journal of Pharmacology 41, 171–182.CrossRefGoogle ScholarPubMed
MacMillan, HL, Boyle, MH, Wong, MY, Duku, EK, Fleming, JE, Walsh, CA (1999). Slapping and spanking in childhood and its association with lifetime prevalence of psychiatric disorders in a general population sample. Canadian Medical Association Journal 161, 805–809.Google Scholar
Marcelis, M, van Os, J, Sham, P, Jones, P, Gilvarry, C, Cannon, M, McKenzie, K, Murray, R (1998). Obstetric complications and familial morbid risk of psychiatric disorders. American Journal of Medical Genetics 81, 29–36.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Menti, E, Lekka, NP, Assimakopoulos, K, Varvarigou, A, Beratis, NG, Beratis, S (2007). Smoking, psychosocial factors, psychopathologic behavior, and other related conditions in hospitalized youth suicide attempters. Comprehensive Psychiatry 48, 522–528.CrossRefGoogle ScholarPubMed
Mokler, DJ, Robinson, SE, Johnson, JH, Hong, JS, Rosecrans, JA (1987). Neonatal administration of delta-9-tetrahydrocannabinol (THC) alters the neurochemical response to stress in the adult Fischer-344 rat. Neurotoxicology and Teratology 9, 321–327.CrossRefGoogle ScholarPubMed
Moore, TH, Zammit, S, Lingford-Hughes, A, Barnes, TR, Jones, PB, Burke, M, Lewis, G (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370, 319–328.CrossRefGoogle ScholarPubMed
Morgan, CJ, Schafer, G, Freeman, TP, Curran, HV (2010). Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected]. British Journal of Psychiatry 197, 285–290.CrossRefGoogle ScholarPubMed
Myin-Germeys, I, Delespaul, P, van Os, J (2005). Behavioural sensitization to daily life stress in psychosis. Psychological Medicine 35, 733–741.CrossRefGoogle ScholarPubMed
Peters, ER, Day, S, Garety, PA (1996). The Peters et al. Delusions Inventory (PDI): new forms for the 21-item version. Schizophrenia Research 18, 118.CrossRefGoogle Scholar
Polanczyk, G, Moffitt, TE, Arseneault, L, Cannon, M, Ambler, A, Keefe, RS, Houts, R, Odgers, CL, Caspi, A (2010). Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Archives of General Psychiatry 67, 328–338.CrossRefGoogle ScholarPubMed
Poulton, R, Caspi, A, Moffitt, TE, Cannon, M, Murray, R, Harrington, H (2000). Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Archives of General Psychiatry 57, 1053–1058.CrossRefGoogle ScholarPubMed
Read, J, Bentall, RP, Fosse, R (2009). Time to abandon the bio-bio-bio model of psychosis: exploring the epigenetic and psychological mechanisms by which adverse life events lead to psychotic symptoms. Epidemiologia e Psichiatria Sociale 18, 299–310.CrossRefGoogle ScholarPubMed
Read, J, Perry, BD, Moskowitz, A, Connolly, J (2001). The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model. Psychiatry 64, 319–345.CrossRefGoogle ScholarPubMed
Read, JP, Stern, AL, Wolfe, J, Ouimette, PC (1997). Use of a screening instrument in women's health care: detecting relationships among victimization history, psychological distress, and medical complaints. Women and Health 25, 1–17.CrossRefGoogle ScholarPubMed
Rodrigues, AJ, Leao, P, Carvalho, M, Almeida, OF, Sousa, N (2011). Potential programming of dopaminergic circuits by early life stress. Psychopharmacology (Berlin) 214, 107–120.CrossRefGoogle ScholarPubMed
Schreier, A, Wolke, D, Thomas, K, Horwood, J, Hollis, C, Gunnell, D, Lewis, G, Thompson, A, Zammit, S, Duffy, L, Salvi, G, Harrison, G (2009). Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years. Archives of General Psychiatry 66, 527–536.CrossRefGoogle Scholar
Scott, J, Chant, D, Andrews, G, Martin, G, McGrath, J (2007). Association between trauma exposure and delusional experiences in a large community-based sample. British Journal of Psychiatry 190, 339–343.CrossRefGoogle Scholar
Semple, DM, McIntosh, AM, Lawrie, SM (2005). Cannabis as a risk factor for psychosis: systematic review. Journal of Psychopharmacology 19, 187–194.CrossRefGoogle ScholarPubMed
Shevlin, M, Dorahy, MJ, Adamson, G (2007). Trauma and psychosis: an analysis of the National Comorbidity Survey. American Journal of Psychiatry 164, 166–169.CrossRefGoogle ScholarPubMed
Shevlin, M, Houston, JE, Dorahy, MJ, Adamson, G (2008). Cumulative traumas and psychosis: an analysis of the National Comorbidity Survey and the British Psychiatric Morbidity Survey. Schizophrenia Bulletin 34, 193–199.CrossRefGoogle ScholarPubMed
Shevlin, M, Murphy, J, Houston, JE, Adamson, G (2009). Childhood sexual abuse, early cannabis use, and psychosis: testing the effects of different temporal orderings based on the National Comorbidity Survey. Psychosis: Psychological, Social and Integrative Approaches 1, 19–28.CrossRefGoogle Scholar
Smeets, R (1993). Composite International Diagnostic Interview (CIDI), version 1.1. World Health Organization: Geneva.Google Scholar
Soliman, A, O'Driscoll, GA, Pruessner, J, Holahan, AL, Boileau, I, Gagnon, D, Dagher, A (2008). Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study. Neuropsychopharmacology 33, 2033–2041.CrossRefGoogle ScholarPubMed
Spauwen, J, Krabbendam, L, Lieb, R, Wittchen, HU, van Os, J (2006). Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness. British Journal of Psychiatry 188, 527–533.CrossRefGoogle ScholarPubMed
Stefanis, NC, Delespaul, P, Henquet, C, Bakoula, C, Stefanis, CN, van Os, J (2004). Early adolescent cannabis exposure and positive and negative dimensions of psychosis. Addiction 99, 1333–1341.CrossRefGoogle ScholarPubMed
Stokes, PR, Egerton, A, Watson, B, Reid, A, Breen, G, Lingford-Hughes, A, Nutt, DJ, Mehta, MA (2010). Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge. NeuroImage 52, 1521–1527.CrossRefGoogle ScholarPubMed
Stokes, PR, Mehta, MA, Curran, HV, Breen, G, Grasby, PM (2009). Can recreational doses of THC produce significant dopamine release in the human striatum? NeuroImage 48, 186–190.CrossRefGoogle ScholarPubMed
Tanda, G, Pontieri, FE, Di Chiara, G (1997). Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science 276, 2048–2050.CrossRefGoogle ScholarPubMed
Tidey, JW, Miczek, KA (1996). Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study. Brain Research 721, 140–149.CrossRefGoogle ScholarPubMed
Tzoumaka-Bakoula, C (1987). The Greek National Perinatal Survey. I: Design, methodology, case ascertainment. Paediatric and Perinatal Epidemiology 1, 43–55.CrossRefGoogle ScholarPubMed
van Os, J, Bak, M, Hanssen, M, Bijl, RV, de Graaf, R, Verdoux, H (2002). Cannabis use and psychosis: a longitudinal population-based study. American Journal of Epidemiology 156, 319–327.CrossRefGoogle ScholarPubMed
van Os, J, Kapur, S (2009). Schizophrenia. Lancet 374, 635–645.CrossRefGoogle ScholarPubMed
van Os, J, Pedersen, CB, Mortensen, PB (2004). Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. American Journal of Psychiatry 161, 2312–2314.CrossRefGoogle ScholarPubMed
van Os, J, Sham, P (2003). Gene-environment interactions. In The Epidemiology of Schizophrenia (ed. Murray, R. M., Jones, P. B., Susser, E., van Os and, J. Cannon, M.), pp. 235–254. Cambridge University Press: Cambridge.Google Scholar
Verdoux, H, Gindre, C, Sorbara, F, Tournier, M, Swendsen, JD (2003 a). Effects of cannabis and psychosis vulnerability in daily life: an experience sampling test study. Psychological Medicine 33, 23–32.CrossRefGoogle ScholarPubMed
Verdoux, H, Sorbara, F, Gindre, C, Swendsen, JD, van Os, J (2003 b). Cannabis use and dimensions of psychosis in a nonclinical population of female subjects. Schizophrenia Research 59, 77–84.CrossRefGoogle Scholar
Voruganti, LN, Slomka, P, Zabel, P, Mattar, A, Awad, AG (2001). Cannabis induced dopamine release: an in-vivo SPECT study. Psychiatry Research 107, 173–177.CrossRefGoogle ScholarPubMed
Whitfield, CL, Dube, SR, Felitti, VJ, Anda, RF (2005). Adverse childhood experiences and hallucinations. Child Abuse and Neglect 29, 797–810.CrossRefGoogle ScholarPubMed
Wicks, S, Hjern, A, Gunnell, D, Lewis, G, Dalman, C (2005). Social adversity in childhood and the risk of developing psychosis: a national cohort study. American Journal of Psychiatry 162, 1652–1657.CrossRefGoogle ScholarPubMed
Wone, I, Dia, AT, Ndiaye, P, Fall, IS, Sarr, YF (2004). Prevalence of cannabis use among students in Dakar [in French]. Santé 14, 49–53.Google ScholarPubMed
Wurr, CJ, Partridge, IM (1996). The prevalence of a history of childhood sexual abuse in an acute adult inpatient population. Child Abuse and Neglect 20, 867–872.CrossRefGoogle Scholar
Zammit, S, Spurlock, G, Williams, H, Norton, N, Williams, N, O'Donovan, MC, Owen, MJ (2007). Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. British Journal of Psychiatry 191, 402–407.CrossRefGoogle ScholarPubMed