Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-12-02T19:39:55.087Z Has data issue: false hasContentIssue false

Initial response to drugs in depressive illness and psychiatric and community adjustment a year later

Published online by Cambridge University Press:  09 July 2009

Allen Raskin*
Affiliation:
Psychopharmacology Research Branch, National Institute of Mental Health, Maryland, USA
Helvi Boothe
Affiliation:
Psychopharmacology Research Branch, National Institute of Mental Health, Maryland, USA
Natalie Reatig
Affiliation:
Psychopharmacology Research Branch, National Institute of Mental Health, Maryland, USA
Joy G. Schulterbrandt
Affiliation:
Psychopharmacology Research Branch, National Institute of Mental Health, Maryland, USA
*
1Address for correspondence: Dr Allen Raskin, Psycho-pharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Lane, Room 9–101, Rockville, Maryland 20857, USA.

Synopsis

Three hundred and sixty depressed in-patients initialy treated with imipramine, chlorpromazine or a placebo were re-evaluated a year later. Patients showing the poorest adjustment at one year were those who failed to show a good initial response to treatment and those who responded positively to a placebo.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Burrows, G. D., Vohra, J., Hunt, D., Sloman, J. G., Scoggins, B. A. & Davis, B. (1976). Cardiac effects of different tricyclic antidepressant drugs. British Journal of Psychiatry 129, 335341.CrossRefGoogle ScholarPubMed
Carlson, G. A., Kotin, J., Davenport, Y. B. & Adland, M. (1974). Follow-up of 53 bipolar manic-depressive patients. British Journal of Psychiatry 124, 134139.CrossRefGoogle ScholarPubMed
Covi, L., Lipman, R. S., Derogatis, L. R., Smith, J. E. & Pattison, J. H. (1974). Drugs and group psychotherapy in neurotic depression. American Journal of Psychiatry 131, 191198.CrossRefGoogle ScholarPubMed
Hankoff, L. D., Freedman, N. & Engelhardt, D. M. (1958). The prognostic value of placebo response. American Journal of Psychiatry 115, 549550.Google Scholar
Honigfeld, G. & Lasky, J. J. (1962). One year follow-up of depressed patients treated in a multi-hospital drug study. Diseases of the Nervous System 23, 18.Google Scholar
Klerman, G. L. & Cole, J. O. (1965). Clinical pharmacology of imipramine and related antidepressant compounds. pharmacological Review 17, 101141.Google Scholar
Klerman, G. L., DiMascio, A., Weissman, M., Prusoff, B. & Paykel, E. S. (1974). Treatment of depression by drugs and psychotherapy. American Journal of Psychiatry 131, 186191.CrossRefGoogle ScholarPubMed
Mindham, R. H. S., Howland, C. & Shepherd, M. (1972). Continuation therapy with tricyclic antidepressants in depressive illness. Lancet ii, 854855.Google Scholar
Mindham, R. H. S., Howland, C. & Shepherd, M. (1973). An evaluation of continuation therapy with tricyclic antidepressants in depressive illness. Psychological Medicine 3, 517.Google Scholar
Oltman, J. E. & Friedman, S. (1964). Relapses following treatment with antidepressant drugs. Diseases of the Nervous System 25, 699701.Google Scholar
Paykel, E. S., Price, J. S., Gillan, R. V., Palmai, G. & Chesser, E. S. (1968). A comparative trial of imipramine and chlorpromazine in depressed patients. British Journal of Psychiatry 114, 12811287.CrossRefGoogle ScholarPubMed
Prien, R. F., Klett, C. J. & Caffey, E. M. Jr (1974). Lithium prophylaxis in recurrent affective illness. American Journal of Psychiatry 131, 198203.CrossRefGoogle ScholarPubMed
Raskin, A., Schulterbrandt, J. G., Reatig, N. & McKeon, J. J. (1969). Replication of factors of psychopathology in interview, ward behavior and self-report ratings of hospitalized depressives. Journal of Nervous and Mental Disease 148, 8798.CrossRefGoogle ScholarPubMed
Raskin, A., Schulterbrandt, J. G., Reatig, N. & McKeon, J. J. (1970). Differential response to chlorpromazine, imipramine and placebo: a study of subgroups of hospitalized depressed patients. Archives of General Psychiatry 23, 164173.Google Scholar
Raskin, A., Boothe, H., Schulterbrandt, J. S., Reatig, N. & Odle, D. (1973). A model for drug use with depressed patients. Journal of Nervous and Mental Disease 156, 130142.Google Scholar
Robins, E. & Guze, S. B. (1972). Classification of affective disorders: The primary-secondary, the endogenous-reactive, and the neurotic-psychotic concepts. In Recent Advances in the Psychobiology of the Depressive Illnesses (ed. Williams, T., Katz, M. M. and Shield, J. A. Jr), pp. 283297. US Government Printing Office: Washington, D.C.Google Scholar
Weissman, M. M., Kasl, S. V. & Klerman, G. L. (1976). Follow-up of depressed women after maintenance treatment. American Journal of Psychiatry 133, 757760.Google ScholarPubMed
Winer, B.J. (1962). Statistical Principles in Experimental Design, p. 87. McGraw-Hill: New York.CrossRefGoogle Scholar