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The impact of parental mental illness across the full diagnostic spectrum on externalising and internalising vulnerabilities in young offspring

Published online by Cambridge University Press:  14 January 2018

Kimberlie Dean ,
Melissa J. Green ,
Kristin R. Laurens ,
Maina Kariuki ,
Stacy Tzoumakis ,
Titia Sprague ,
Rhoshel Lenroot  and
Vaughan J. Carr
Kimberlie Dean*
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Neuroscience Research Australia, Sydney, Australia Justice Health & Forensic Mental Health Network, NSW, Australia
Melissa J. Green
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Neuroscience Research Australia, Sydney, Australia
Kristin R. Laurens
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Neuroscience Research Australia, Sydney, Australia School of Psychology, Australian Catholic University, Brisbane, Australia
Maina Kariuki
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia
Stacy Tzoumakis
Affiliation:
School of Social Sciences, University of New South Wales, Sydney, Australia
Titia Sprague
Affiliation:
NSW Ministry of Health, NSW, Australia
Rhoshel Lenroot
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia
Vaughan J. Carr
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Neuroscience Research Australia, Sydney, Australia Department of Psychiatry, School of Clinical Sciences, Monash University, Melbourne, Australia
*
Author for correspondence: Kimberlie Dean, E-mail: [email protected]
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Abstract

Background

The intergenerational risk for mental illness is well established within diagnostic categories, but the risk is unlikely to respect diagnostic boundaries and may be reflected more broadly in early life vulnerabilities. We aimed to establish patterns of association between externalising and internalising vulnerabilities in early childhood and parental mental disorder across the full spectrum of diagnoses.

Methods

A cohort of Australian children (n = 69 116) entering the first year of school in 2009 were assessed using the Australian Early Development Census, providing measures of externalising and internalising vulnerability. Parental psychiatric diagnostic status was determined utilising record-linkage to administrative health datasets.

Results

Parental mental illness, across diagnostic categories, was associated with all child externalising and internalising domains of vulnerability. There was little evidence to support interaction by parental or offspring sex.

Conclusions

These findings have important implications for informing early identification and intervention strategies in high-risk offspring and for research into the causes of mental illness. There may be benefits to focusing less on diagnostic categories in both cases.

Keywords

Internalisingexternalisingparental mental illnessintergenerationalchildhood
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 13 , October 2018 , pp. 2257 - 2263
Copyright
Copyright © Cambridge University Press 2018 

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References

Brinkman, SA, Gregory, TA, Goldfeld, S, Lynch, JW and Hardy, M (2014) Data resource profile: the Australian early development index (AEDI). International Journal of Epidemiology 43, 1089–1096.Google Scholar
Carr, VJ, Harris, F, Raudino, A, Luo, L, Kariuki, M, Liu, E et al. (2016) New South Wales child development study (NSW-CDS): an Australian multiagency, multigenerational, longitudinal record linkage study. BMJ open 6, e009023.Google Scholar
Caspi, A, Houts, RM, Belsky, DW, Goldman-Mellor, SJ, Harrington, H, Israel, S et al. (2014) The p factor: one general psychopathology factor in the structure of psychiatric disorders? Clinical Psychological Science 2, 119–137.Google Scholar
Connell, AM and Goodman, SH (2002) The association between psychopathology in fathers versus mothers and children's internalizing and externalizing behavior problems: a meta-analysis. Psychological Bulletin 128, 746.Google Scholar
Dean, CE (2012) The death of specificity in psychiatry: cheers or tears? Perspectives in Biology and Medicine 55, 443–460.Google Scholar
Dean, K, Stevens, H, Mortensen, PB, Murray, RM, Walsh, E and Pedersen, CB (2010) Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder. Archives of General Psychiatry 67, 822–829.Google Scholar
Fergusson, DM and Lynskey, MT (1993) The effects of maternal depression on child conduct disorder and attention deficit behaviours. Social Psychiatry and Psychiatric Epidemiology 28, 116–123.Google Scholar
Fudge, E, Falkov, A, Kowalenko, N and Robinson, P (2004) Parenting is a mental health issue. Australasian Psychiatry 12, 166–171.Google Scholar
Goodman, SH and Gotlib, IH (1999) Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission. Psychological Review 106, 458.Google Scholar
Grietens, H, Onghena, P, Prinzie, P, Gadeyne, E, Van Assche, V, Ghesquière, P et al. (2004) Comparison of mothers', fathers', and teachers' reports on problem behavior in 5-to 6-year-old children. Journal of Psychopathology and Behavioral Assessment 26, 137–146.Google Scholar
Hameed, MA and Lewis, AJ (2016) Offspring of parents with schizophrenia: a systematic review of developmental features across childhood. Harvard Review of Psychiatry 24, 104–117.Google Scholar
Janus, M (2010) Estimating prevalence of behaviour problems in kindergarten children based on population-level data. In Zukauskiene R (Ed.) Proceedings From the XIV European Conference on Developmental Psychology. Bologna, Italy: Medimond, pp. 193–198.Google Scholar
Janus, M and Offord, DR (2007) Development and psychometric properties of the early development instrument (EDI): a measure of children's school readiness. Canadian Journal of Behavioural Science/Revue canadienne des sciences du comportement 39, 1–22.Google Scholar
Johnson, JG, Cohen, P, Kasen, S, Smailes, E and Brook, JS (2001) Association of maladaptive parental behavior with psychiatric disorder among parents and their offspring. Archives of General Psychiatry 58, 453–460.Google Scholar
Laurens, KR, Luo, L, Matheson, SL, Carr, VJ, Raudino, A, Harris, F et al. (2015) Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry 15, 1–20.Google Scholar
Luoma, I, Tamminen, T, Kaukonen, P, Laippala, P, Puura, K, Salmelin, R et al. (2001) Longitudinal study of maternal depressive symptoms and child well-being. Journal of the American Academy of Child & Adolescent Psychiatry 40, 1367–1374.Google Scholar
Mesman, E, Nolen, WA, Reichart, CG, Wals, M and Hillegers, MH (2013) The Dutch bipolar offspring study: 12-year follow-up. American Journal of Psychiatry 170, 542–549.Google Scholar
Murray, AL, Eisner, M and Ribeaud, D (2016) The development of the general factor of psychopathology ‘p factor'through childhood and adolescence. Journal of Abnormal Child Psychology 44, 1573–1586.Google Scholar
Nordahl, HM, Ingul, JM, Nordvik, H and Wells, A (2007) Does maternal psychopathology discriminate between children with DSM-IV generalised anxiety disorder or oppositional defiant disorder? The predictive validity of maternal axis I and axis II psychopathology. European Child & Adolescent Psychiatry 16, 87–95.Google Scholar
Pettersson, E, Larsson, H and Lichtenstein, P (2016) Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population. Molecular Psychiatry 21, 717–721.Google Scholar
Phares, V and Compas, BE (1992) The role of fathers in child and adolescent psychopathology: make room for daddy. Psychological Bulletin 111, 387.Google Scholar
Pink, B (2013) Socio-Economic Indexes for Areas (SEIFA) 2011, Technical Paper. (ed. Australian Bureau of Statistics). Canberra: Commonwealth of Australia.Google Scholar
Plomin, R, Krapohl, E and O'Reilly, PF (2016) Assortative mating – a missing piece in the jigsaw of psychiatric genetics. JAMA Psychiatry 73, 323–324.Google Scholar
Rasic, D, Hajek, T, Alda, M and Uher, R (2013) Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies. Schizophrenia Bulletin 40, 28–38.Google Scholar
Rutter, M (1966) Children of Sick Parents: An Environmental and Psychiatric Study. London: Oxford U.P.Google Scholar
Rutter, M and Quinton, D (1984) Parental psychiatric disorder: effects on children. Psychological Medicine 14, 853–880.Google Scholar
Sara, G, Luo, L, Carr, VJ, Raudino, A, Green, MJ, Laurens, KR et al. (2014) Comparing algorithms for deriving psychosis diagnoses from longitudinal administrative clinical records. Social Psychiatry and Psychiatric Epidemiology 49, 1729–1737.Google Scholar
Smith, M (2004) Parental mental health: disruptions to parenting and outcomes for children. Child & Family Social Work 9, 3–11.Google Scholar
van Santvoort, F, Hosman, CM, Janssens, JM, van Doesum, KT, Reupert, A and van Loon, LM (2015) The impact of various parental mental disorders on children's diagnoses: a systematic review. Clinical Child and Family Psychology Review 18, 281–299.Google Scholar
Van Snellenberg, JX and de Candia, T (2009) Meta-analytic evidence for familial coaggregation of schizophrenia and bipolar disorder. Archives of General Psychiatry 66, 748–755.Google Scholar
Vostanis, P, Graves, A, Meltzer, H, Goodman, R, Jenkins, R and Brugha, T (2006) Relationship between parental psychopathology, parenting strategies and child mental health. Social Psychiatry and Psychiatric Epidemiology 41, 509–514.Google Scholar
Welham, J, Isohanni, M, Jones, P and McGrath, J (2009) The antecedents of schizophrenia: a review of birth cohort studies. Schizophrenia Bulletin 35, 603–623.Google Scholar
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