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Effort valuation and psychopathology in children and adults

Published online by Cambridge University Press:  14 January 2019

Nicholas H. Nguyen Open the ORCID record for Nicholas H. Nguyen [Opens in a new window] ,
Avery B. Albert ,
Sarah Van Orman ,
Patricia Forken ,
Steven D. Blatt ,
Wanda P. Fremont ,
Stephen V. Faraone  and
Stephen J. Glatt Open the ORCID record for Stephen J. Glatt [Opens in a new window]
Nicholas H. Nguyen
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
Avery B. Albert
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA Department of Psychology, Syracuse University, Syracuse, New York, USA
Sarah Van Orman
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
Patricia Forken
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
Steven D. Blatt
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
Wanda P. Fremont
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
Stephen V. Faraone
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
Stephen J. Glatt*
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York – Upstate Medical University, Syracuse, New York, USA
*
Author for correspondence: Stephen J. Glatt, E-mail: [email protected]
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Abstract

Background

The Research Domain Criteria initiative was launched by the US National Institute of Mental Health to establish a multi-level framework for understanding psychological constructs relevant to human psychiatric disorders, and identified ‘effort valuation/willingness to work’ as a clinically useful construct worthy of further study. This construct encompasses the processes by which the cost(s) of obtaining an outcome are calculated, and the tendency to overcome response costs to obtain a reinforcer. The current study aims to examine effort valuation as a correlate of psychopathology in children and adults, and the moderating effects of sex on this relationship.

Methods

Participants were 1215 children aged 6–12 and their parents (n = 1044). All participants completed the Effort Expenditure for Rewards Task as a measure of effort expenditure. Child psychopathology was measured via the Child Behavior Checklist, while adult psychopathology was measured via the Adult Self Report. Additionally, the Social Adjustment Inventory for Children and Adolescents and Injury Behavior Checklist were used to examine child social impairments/problem behaviors.

Results

In children, significant interactions between reward sensitivity and sex were observed in association with anxiety and thought problems, specifically at low reward sensitivity levels. In adults, main effects of effort expenditure were seen in drug and alcohol abuse, where higher effort was associated with higher degrees of abuse.

Conclusions

These results establish effort valuation as a relevant psychological construct for understanding psychopathology, but with different profiles of associated psychopathology across sex in children and adults.

Keywords

EEfRTeffort valuationpsychopathologyRDoCreward
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 16 , December 2019 , pp. 2801 - 2807
Copyright
Copyright © Cambridge University Press 2019 

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Footnotes

*

These authors contributed equally to this work.

References

Achenbach, TM (1991) Integrative guide to the 1991 CBCL/4-18 YSR, and TRF profiles. University of Vermont, Department of Psychology Pediatrics 108, e14.Google Scholar
Altemus, M, Sarvaiya, N and Neill Epperson, C (2014) Sex differences in anxiety and depression clinical perspectives. Frontiers in Neuroendocrinology 35, 320–330.Google Scholar
Barch, DM, Treadway, MT and Schoen, N (2014) Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment. Journal of Abnormal Psychology 123, 387–397.Google Scholar
Benjamini, Y and Hochberg, Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society B 57, 289–300.Google Scholar
Benozio, A and Diesendruck, G (2015) From effort to value. Psychological Science 26, 1423–1429.Google Scholar
Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, SH, Ripke, S, Neale, BM, Faraone, SV, Purcell, SM, Perlis, RH, Mowry, BJ, Thapar, A, Goddard, ME, Witte, JS, Absher, D, Agartz, I, Akil, H, Amin, F, Andreassen, OA, Anjorin, A, Anney, R, Anttila, V, Arking, DE, Asherson, P, Azevedo, MH, Backlund, L, Badner, JA, Bailey, AJ, Banaschewski, T, Barchas, JD, Barnes, MR, Barrett, TB, Bass, N, Battaglia, A, Bauer, M, Bayés, M, Bellivier, F, Bergen, SE, Berrettini, W, Betancur, C, Bettecken, T, Biederman, J, Binder, EB, Black, DW, Blackwood, DH, Bloss, CS, Boehnke, M, Boomsma, DI, Breen, G, Breuer, R, Bruggeman, R, Cormican, P, Buccola, NG, Buitelaar, JK, Bunney, WE, Buxbaum, JD, Byerley, WF, Byrne, EM, Caesar, S, Cahn, W, Cantor, RM, Casas, M, Chakravarti, A, Chambert, K, Choudhury, K, Cichon, S, Cloninger, CR, Collier, DA, Cook, EH, Coon, H, Cormand, B, Corvin, A, Coryell, WH, Craig, DW, Craig, IW, Crosbie, J, Cuccaro, ML, Curtis, D, Czamara, D, Datta, S, Dawson, G, Day, R, De Geus, EJ, Degenhardt, F, Djurovic, S, Donohoe, GJ, Doyle, AE, Duan, J, Dudbridge, F, Duketis, E, Ebstein, RP, Edenberg, HJ, Elia, J, Ennis, S, Etain, B, Fanous, A, Farmer, AE, Ferrier, IN, Flickinger, M, Fombonne, E, Foroud, T, Frank, J, Franke, B, Fraser, C, Freedman, R, Freimer, NB, Freitag, CM, Friedl, M, Frisén, L, Gallagher, L, Gejman, PV, Georgieva, L, Gershon, ES, Geschwind, DH, Giegling, I, Gill, M, Gordon, SD, Gordon-Smith, K, Green, EK, Greenwood, TA, Grice, DE, Gross, M, Grozeva, D, Guan, W, Gurling, H, De Haan, L, Haines, JL, Hakonarson, H, Hallmayer, J, Hamilton, SP, Hamshere, ML, Hansen, TF, Hartmann, AM, Hautzinger, M, Heath, AC, Henders, AK, Herms, S, Hickie, IB, Hipolito, M, Hoefels, S, Holmans, PA, Holsboer, F, Hoogendijk, WJ, Hottenga, JJ, Hultman, CM, Hus, V, Ingason, A, Ising, M, Jamain, S, Jones, EG, Jones, I, Jones, L, Tzeng, JY, Kähler, AK, Kahn, RS, Kandaswamy, R, Keller, MC, Kennedy, JL, Kenny, E, Kent, L, Kim, Y, Kirov, GK, Klauck, SM, Klei, L, Knowles, JA, Kohli, MA, Koller, DL, Konte, B, Korszun, A, Krabbendam, L, Krasucki, R, Kuntsi, J, Kwan, P, Landén, M, Långström, N, Lathrop, M, Lawrence, J, Lawson, WB, Leboyer, M, Ledbetter, DH, Lee, PH, Lencz, T, Lesch, KP, Levinson, DF, Lewis, CM, Li, J, Lichtenstein, P, Lieberman, JA, Lin, DY, Linszen, DH, Liu, C, Lohoff, FW, Loo, SK, Lord, C, Lowe, JK, Lucae, S, MacIntyre, DJ, Madden, PA, Maestrini, E, Magnusson, PK, Mahon, PB, Maier, W, Malhotra, AK, Mane, SM, Martin, CL, Martin, NG, Mattheisen, M, Matthews, K, Mattingsdal, M, McCarroll, SA, McGhee, KA, McGough, JJ, McGrath, PJ, McGuffin, P, McInnis, MG, McIntosh, A, McKinney, R, McLean, AW, McMahon, FJ, McMahon, WM, McQuillin, A, Medeiros, H, Medland, SE, Meier, S, Melle, I, Meng, F, Meyer, J, Middeldorp, CM, Middleton, L, Milanova, V, Miranda, A, Monaco, AP, Montgomery, GW, Moran, JL, Moreno-De-Luca, D, Morken, G, Morris, DW, Morrow, EM, Moskvina, V, Muglia, P, Mühleisen, TW, Muir, WJ, Müller-Myhsok, B, Murtha, M, Myers, RM, Myin-Germeys, I, Neale, MC, Nelson, SF, Nievergelt, CM, Nikolov, I, Nimgaonkar, V, Nolen, WA, Nöthen, MM, Nurnberger, JI, Nwulia, EA, Nyholt, DR, O'Dushlaine, C, Oades, RD, Olincy, A, Oliveira, G, Olsen, L, Ophoff, RA, Osby, U, Owen, MJ, Palotie, A, Parr, JR, Paterson, AD, Pato, CN, Pato, MT, Penninx, BW, Pergadia, ML, Pericak-Vance, MA, Pickard, BS, Pimm, J, Piven, J, Posthuma, D, Potash, JB, Poustka, F, Propping, P, Puri, V, Quested, DJ, Quinn, EM, Ramos-Quiroga, JA, Rasmussen, HB, Raychaudhuri, S, Rehnström, K, Reif, A, Ribasés, M, Rice, JP, Rietschel, M, Roeder, K, Roeyers, H, Rossin, L, Rothenberger, A, Rouleau, G, Ruderfer, D, Rujescu, D, Sanders, AR, Sanders, SJ, Santangelo, SL, Sergeant, JA, Schachar, R, Schalling, M, Schatzberg, AF, Scheftner, WA, Schellenberg, GD, Scherer, SW, Schork, NJ, Schulze, TG, Schumacher, J, Schwarz, M, Scolnick, E, Scott, LJ, Shi, J, Shilling, PD, Shyn, SI, Silverman, JM, Slager, SL, Smalley, SL, Smit, JH, Smith, EN, Sonuga-Barke, EJ, St Clair, D, State, M, Steffens, M, Steinhausen, HC, Strauss, JS, Strohmaier, J, Stroup, TS, Sutcliffe, JS, Szatmari, P, Szelinger, S, Thirumalai, S, Thompson, RC, Todorov, AA, Tozzi, F, Treutlein, J, Uhr, M, van den Oord, EJ, Van Grootheest, G, Van Os, J, Vicente, AM, Vieland, VJ, Vincent, JB, Visscher, PM, Walsh, CA, Wassink, TH, Watson, SJ, Weissman, MM, Werge, T, Wienker, TF, Wijsman, EM, Willemsen, G, Williams, N, Willsey, AJ, Witt, SH, Xu, W, Young, AH, Yu, TW, Zammit, S, Zandi, PP, Zhang, P, Zitman, FG, Zöllner, S, Devlin, B, Kelsoe, JR, Sklar, P, Daly, MJ, O'Donovan, MC, Craddock, N, Sullivan, PF, Smoller, JW, Kendler, KS, Wray, NR, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45, 984–994.Google Scholar
Cuthbert, BN (2014) The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 13, 28–35.Google Scholar
Damiano, CR, Aloi, J, Treadway, M, Bodfish, JW and Dichter, GS (2012) Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions. Journal of Neurodevelopmental Disorders 4, 1–10. doi: 10.1186/1866-1955-4-13.Google Scholar
Derdikman-Eiron, R, Indredavik, MS, Bakken, IJ, Bratberg, GH, Hjemdal, O and Colton, M (2012) Gender differences in psychosocial functioning of adolescents with symptoms of anxiety and depression: longitudinal findings from the Nord-Trondelag Health Study. Social Psychiatry and Psychiatric Epidemiology 47, 1855–1863.Google Scholar
Dorfman, J, Rosen, D, Pine, D and Ernst, M (2016) Anxiety and gender influence reward-related processes in children and adolescents. Journal of Child and Adolescent Psychopharmacology 26, 380–390.Google Scholar
Ji, Y, Hong, X, Wang, G, Chatterjee, N, Riley, AW, Lee, L, Surkan, PJ, Bartell, TR, Zuckerman, B and Wang, X (2018) A prospective birth cohort study on early childhood lead levels and attention deficit hyperactivity disorder: new insight on sex differences. The Journal of Pediatrics 199, 124–131.Google Scholar
John, K, Gammon, GD, Prusoff, BA and Warner, V (1987) The Social Adjustment Inventory for Children and Adolescents (SAICA): testing of a new semistructured interview. Journal of the American Academy of Child and Adolescent Psychiatry 26, 898–911. Available at http://www.ncbi.nlm.nih.gov/pubmed/3429410 (Accessed 16 April 2018).Google Scholar
Loomes, R, Hull, L and Mandy, WPL (2017) What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry 56, 466–474.Google Scholar
Mazefsky, CA, Anderson, R, Conner, CM and Minshew, N (2011) Child behavior checklist scores for school-aged children with autism: preliminary evidence of patterns suggesting the need for referral. Journal of Psychopathology and Behavioral Assessment 33, 31–37.Google Scholar
McCarthy, JM, Treadway, MT, Bennett, ME and Blanchard, JJ (2016) Inefficient effort allocation and negative symptoms in individuals with schizophrenia. Schizophrenia Research 170, 278–284.Google Scholar
Mosner, MG, Kinard, JL, McWeeny, SS, Jasmine, S, Markiewitz, ND, Damiano-Goodwin, CR, Burchinal, MR, Rutherford, HJV, Greene, RK, Treadway, MT and Dichter, GS (2017) Vicarious effort-based decision-making in autism spectrum disorders. Journal of Autism and Developmental Disorders 47, 2992–3006.Google Scholar
NIMH (2016) NIMH Subconstruct: Effort. [online] Available at: https://www.nimh.nih.gov/research-priorities/rdoc/constructs/effort.shtml [Accessed 1 Mar. 2018].Google Scholar
Olino, TM, Silk, J, Osterriter, C and Forbes, EE (2015) Social reward in youth at risk for depression: a preliminary investigation of subjective and neural differences. Journal of Child and Adolescent Psychopharmacology 25, 711–721.Google Scholar
Perneger, TV (1998) What's wrong with Bonferroni adjustments. BMJ 316, 1236–1238.Google Scholar
Potts, R, Martinez, IG, Dedmon, A, Schwarz, L, DiLillo, D and Swisher, L (1997) Brief report: cross-validation of the injury behavior checklist in a school-age sample. Journal of Pediatric Psychology 22, 533–540. Available at http://jpepsy.oxfordjournals.org/content/22/4/533.abstract%5Cnpapers3://publication/uuid/56A47B28-1953-4CAE-9167-4A62688147E9.Google Scholar
Rescorla, LA and Achenbach, TM (2004) The Achenbach System of Empirically Based Assessment (ASEBA) for ages 18 to 90 years. In The Use of Psychological Testing for Treatment Planning and Outcomes Assessment, Volume 3: Instruments for adults, pp. 115–152, Mahwah, NJ, US: Lawrence Erlbaum Associates Publishers.Google Scholar
Scott-Van Zeeland, AA, Dapretto, M, Ghahremani, DG, Poldrack, RA and Bookheimer, SY (2010) Reward processing in autism. Autism Research: Official Journal of the International Society for Autism Research 3, 53–67.Google Scholar
Treadway, MT, Buckholtz, JW, Schwartzman, AW, Lambert, WE and Zald, DH (2009) Worth the “EEfRT”? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. PLoS ONE 4, 1–9. doi: 10.1371/journal.pone.0006598.Google Scholar
Treadway, MT, Bossaller, NA, Shelton, RG and Zald, DH (2012) Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia. Journal of Abnormal Psychology 121, 553–558.Google Scholar
Treadway, MT, Peterman, JS, Zald, DH and Park, S (2015) Impaired effort allocation in patients with schizophrenia. Schizophrenia Research 161, 382–385.Google Scholar
Venables, NC (2017) Reward mechanisms across aggressive and addictive forms of externalizing psychopathology. Biological Psychiatry 82, e25–e27.Google Scholar
Werling, DM and Geschwind, DH (2013) Sex differences in autism spectrum disorders. Current Opinion in Neurology 26, 146–153.Google Scholar
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