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Verbal fluency in schizophrenia: relationship with executive function, semantic memory and clinical alogia

Published online by Cambridge University Press:  09 July 2009

E. M. Joyce ,
S. L. Collinson  and
P. Crichton
E. M. Joyce*
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School and Queen Mary's University Hospital, London
S. L. Collinson
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School and Queen Mary's University Hospital, London
P. Crichton
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School and Queen Mary's University Hospital, London
*
1Address for correspondence: Dr E. M. Joyce, Mental Health Unit. Queen Mary's University Hospital, Roehampton Lane, London SW15 5PN.
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Synopsis

To examine whether poor verbal fluency in schizophrenia represents a degraded semantic store or inefficient access to a normal semantic store, 25 normal volunteers and 50 DSM-III-R schizophrenic patients, matched for age, sex and IQ, were recruited. Although schizophrenic patients were impaired on both letter and category fluency, they showed a normal pattern of output in that category was superior to letter fluency, and an improvement in category fluency when a cueing technique was employed (Randolph et al. 1993). These results resemble those found in disorders of frontostriatal systems (Parkinson's and Huntington's disease) and suggest that poor verbal fluency in schizophrenia is because of inefficient access to semantic store. A measure of improvement with cueing was directly related to performance on the Stroop executive task. Of all symptom measures derived from SANS and Manchester Scales, only alogia was related to verbal fluency in that superior improvement correlated inversely with the degree of alogia. It is suggested that both alogia and poor verbal fluency are mediated by the same underlying cognitive abnormality that reflects frontostriatal dysfunction.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 1 , January 1996 , pp. 39 - 49
Copyright
Copyright © Cambridge University Press 1996

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References

REFERENCES

Allen, H. A., Liddle, P. F. & Frith, C. D. (1993). Negative features, retrieval processes and verbal fluency in schizophrenia. British Journal of Psychiatry 163, 769–775.CrossRefGoogle ScholarPubMed
Andreason, N. (1982). Negative symptoms in schizophrenia: definition and reliability. Archives of General Psychiatry 39, 784–788.CrossRefGoogle Scholar
Baddeley, A. D. (1986). Working Memory. Clarendon Press: Oxford.Google ScholarPubMed
Bench, C. J., Frith, C. D., Grasby, P. M., Friston, K. J., Paulescu, E., Frackowiak, R. S. J. & Dolan, R. J. (1993). Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia 31, 907–922.CrossRefGoogle ScholarPubMed
Benton, A. & Hamsher, K. (1976). Multilingual Aphasia Examination. University of Iowa: Iowa City.Google Scholar
Butters, N., Wolfe, J., Granholm, E. & Martone, M. (1986). An assessment of verbal recall, recognition and fluency abilities in patients with Huntington's disease. Cortex 22, 11–32.CrossRefGoogle ScholarPubMed
Butters, N., Granholm, E., Salmon, D. P. & Grant, I. (1987). Episodic and semantic memory: a comparison of amnesic and demented patients. Journal of Clinical and Experimental Psychology 9, 479–497.Google ScholarPubMed
Crawford, J., Moore, J. & Cameron, I. (1992). Verbal fluency: a NART-based equation for the estimation of premorbid performance. British Journal of Clinical Psychology 31, 327–329.CrossRefGoogle ScholarPubMed
Crawford, J. R., Obonsawin, M. C. & Bremner, M. (1993). Frontal lobe impairment in schizophrenia: relationship to intellectual function. Psychological Medicine 23, 787–790.CrossRefGoogle Scholar
Diesfeldt, H. (1985). Verbal fluency in senile dementia: an analysis of search and knowledge. Archives of Gerontology and Geriatrics 4, 231–239.CrossRefGoogle ScholarPubMed
Frith, C. (1987). The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychological Medicine 17, 631–648.CrossRefGoogle ScholarPubMed
Frith, C., Friston, K., Liddle, P. & Frackowiak, R. (1991 a). A PET study of word finding. Neuropsychologia 29, 1137–1148.CrossRefGoogle ScholarPubMed
Frith, C. D., Friston, K. J., Liddle, P. F. & Frackowiack, R. S. J. (1991 b). Willed action and the prefrontal cortex in man: a study with PET. Proceedings of the Royal Society of London 244, 241–246.Google Scholar
Gold, J., Randolph, C., Carpenter, C., Goldberg, T. & Weinberger, D. (1992). Forms of memory failure in schizophrenia. Journal of Abnormal Psychology 101, 487–494.CrossRefGoogle ScholarPubMed
Goldstein, G. (1978). Cognitive and perceptual differences between schizophrenics and organics. Schizophrenia Bulletin 4, 160–185.CrossRefGoogle ScholarPubMed
Gruenewald, P. & Lockhead, G. (1980). The free recall of category examples. Journal of Experimental Psychology: Human Learning and Memory 6, 225–240.Google Scholar
Gruzelier, J., Seymour, K., Wilson, L., Jolley, A. & Hirsch, S. (1988). Impairments on neuropsychological tests of temporohippocampal and frontohippocampal function and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623–629.CrossRefGoogle ScholarPubMed
Gurd, J. M. & Ward, C. D. (1989). Retrieval from semantic and letter-initial categories in patients with Parkinson's disease. Neuropsychologia 27, 743–746.CrossRefGoogle ScholarPubMed
Hanley, J. R., Dewick, H. C., Davies, A. D., Plafer, J. & Turnbull, C. (1990). Verbal fluency in Parkinson's disease. Neuropsychologia 28, 737–741.CrossRefGoogle ScholarPubMed
Heaton, R. K., Baade, L. E. & Johnson, K. L. (1978). Neuropsychological test results associated with psychiatric disorders in adults. Psychological Bulletin 85, 141–162.CrossRefGoogle ScholarPubMed
Hodges, J. R., Salmon, D. P. & Butters, N. (1990). Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study. Journal of Neurology, Neurosurgery and Psychiatry 53, 1089–1095.CrossRefGoogle Scholar
Hodges, J. R., Patterson, K., Oxbury, S. & Funnel, E. (1992 a). Semantic dementia: Progressive fluent aphasia with temporal lobe atrophy. Brain, 115, 1783–1806.CrossRefGoogle ScholarPubMed
Hodges, J. R., Salmon, D. P. & Butters, N. (1992 b). Semantic memory impairment in Alzheimer's disease: failure of access or degraded knowledge? Neuropsychologia 30, 301–314.CrossRefGoogle ScholarPubMed
Hoff, A., Riordan, H., O'Donnell, M., Morris, L. & DeLisi, L. (1992). Neuropsychological functioning of first-episode schizophreniform patients. American Journal of Psychiatry 149, 898–903.Google ScholarPubMed
Joyce, E. & Robbins, T. (1991). Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: planning and spatial working memory. Neuropsychologia 29, 709–723.CrossRefGoogle ScholarPubMed
Kaplan, E., Goodglass, H. & Weintraub, S. (1983). Boston Naming Test. Lea and Febiger: Philadelphia.Google Scholar
Kolb, B. & Whishaw, I. Q. (1983). Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. Journal of Nervous and Mental Diseases 171, 435–443.CrossRefGoogle ScholarPubMed
Krawiecka, M., Goldberg, D. & Vaughan, M. (1977). A standardised psychiatric assessment for rating chronic psychotic patients. Acta Psychiatrica Scandinavica 55, 299–308.CrossRefGoogle ScholarPubMed
Lezak, M. (1983). Neuropsychological Assessment, 2nd edn.Oxford University Press: New York.Google Scholar
Liddle, P. (1987). The symptoms of chronic schizophrenia: a reexamination of the positive–negative dichotomy. British Journal of Psychiatry 151, 145–151.CrossRefGoogle ScholarPubMed
Liddle, P. & Barnes, T. (1990). Syndromes of chronic schizophrenia. British Journal of Psychiatry 157, 558–561.CrossRefGoogle ScholarPubMed
Liddle, P. & Morris, D. (1991). Schizophrenic syndromes and frontal lobe performance. British Journal of Psychiatry 158, 340–345.CrossRefGoogle ScholarPubMed
Liddle, P., Friston, K. J., Frith, C. D., Hirsch, S. R., Jones, T. & Frackowiak, R. S. J. (1992). Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry 160, 179–186.CrossRefGoogle ScholarPubMed
McKenna, P. J., Mortimer, A. M. & Hodges, J. R. (1994). Semantic memory in schizophrenia. In The Neuropsychology of Schizophrenia (ed. Cutting, J. and David, A.), pp. 163–178. Lawrence Erlbaum Associates: Hove.Google Scholar
Maher, E. R., Smith, E. M. & Lees, A. J. (1985). Cognitive deficits in the Steele–Richardson–Olszewski syndrome (progressive supranuclear palsy). Journal of Neurology, Neurosurgery and Psychiatry 48, 1234–1239.CrossRefGoogle ScholarPubMed
Martin, A. & Fedio, P. (1983). Word production and comprehension in Alzheimer's disease: the breakdown of semantic knowledge. Brain and Language 19, 124–141.CrossRefGoogle ScholarPubMed
Martin, R. C., Loring, D. W., Meador, K. J. & Lee, G. P. (1990). The effects of lateralised temporal lobe dysfunction on formal and semantic fluency. Neuropsychologia 28, 823–829.CrossRefGoogle Scholar
Miller, E. (1984). Verbal fluency as a function of a measure of verbal intelligence and in relation to different types of cerebral pathology. British Journal of Clinical Psychology 23, 53–57.CrossRefGoogle ScholarPubMed
Milner, B. (1964). Some effects of frontal lobectomy in man. In The Frontal Granular Cortex and Behaviour (ed. Warren, J. M. and Akert, K.), pp. 313–344. McGraw-Hill: New York.Google Scholar
Morrison-Stewart, S., Williamson, P., Corning, W., Kutcher, S., Snow, W. & Merskey, H. (1992). Frontal and non-frontal neuropsychological test performance and clinical symptomatology in schizophrenia. Psychological Medicine 22, 353–359.CrossRefGoogle ScholarPubMed
Nelson, H. (1976). The National Adult Reading Test. NFER-Nelson: Windsor.Google Scholar
Norman, D. A. & Shallice, T. (1986). Attention to action: willed and automatic control of behaviour. In Consciousness and Self Regulation (ed. Davidson, R., Schwartz, G. and Shapiro, D.), pp. 1–18. Plenum Press: New York.Google Scholar
Owen, A., Downes, J., Sahakian, B., Polkey, C. & Robbins, T. (1990). Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28, 1021–1034.CrossRefGoogle ScholarPubMed
Owen, A., Roberts, A., Hodges, J., Summers, B., Polky, C. & Robbins, T. W. (1993). Contrasting mechanisms of impaired setshifting in patients with frontal lobe damage. Brain 116, 1159–1175.CrossRefGoogle ScholarPubMed
Pardo, J. V., Pardo, P. J., Janer, K. W. & Raichle, M. E. (1990). The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proceedings of the National Academy of Sciences USA 87, 256–259.CrossRefGoogle ScholarPubMed
Petersen, S. E., Fox, P. T., Posner, M. I., Mintum, M. & Raichle, M. E. (1988). Positron emission studies of the cortical anatomy of single word processing. Nature 331, 585–589.CrossRefGoogle ScholarPubMed
Pillon, B., Dubois, B., L'Hermitte, F. & Agid, Y. (1986). Heterogeneity of cognitive impairment in progressive supranuclear palsy, Parkinson's disease and Alzheimer's disease. Neurology 36, 1179–1185.CrossRefGoogle ScholarPubMed
Randolph, C., Braun, A., Goldberg, T. & Chase, T. (1993). Semantic fluency in Alzheimer's, Parkinson's and Huntington's disease: Dissociation of storage and retrieval failures. Neuropsychology 7, 82–88.CrossRefGoogle Scholar
Robbins, T. (1990). The case for frontostriatal dysfunction in schizophrenia. Schizophrenia Bulletin 16, 391–401.CrossRefGoogle ScholarPubMed
Rosen, W. G. (1980). Verbal fluency in aging and dementia. Journal of Clinical Neuropsychology 2, 135–146.CrossRefGoogle Scholar
Saykin, A., Gur, R., Gur, R., Mozley, D., Mozley, L., Resnick, S., Kester, D. & Stafiniak, P. (1991). Neuropsychological function in schizophrenia. Archives of General Psychiatry 48, 618–624.CrossRefGoogle ScholarPubMed
Shallice, T. (1982). Specific impairments in planning. Philosophical Transactions of the Royal Society of London Series B 298, 199–209.Google ScholarPubMed
Shallice, T. (1988). From Neuropsychology to Mental Structure. Cambridge University Press: Cambridge.CrossRefGoogle Scholar
Shallice, T., Burgess, P. & Frith, C. (1991). Can the neuropsychological case study approach be applied to schizophrenia? Psychological Medicine 21, 661–673.CrossRefGoogle ScholarPubMed
Stroop, J. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology 18, 643–662.CrossRefGoogle Scholar
Tamlyn, D., McKenna, P., Mortimer, A., Lund, C., Hammond, S. & Baddeley, A. (1992). Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character. Psychological Medicine 22, 101–115.CrossRefGoogle ScholarPubMed
Warrington, E. K. & Shallice, T. (1979). Semantic access dyslexia. Brain 102, 43–63.CrossRefGoogle ScholarPubMed