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Reversed lateralization of temporal activation during speech production in thought disordered patients with schizophrenia

Published online by Cambridge University Press:  07 May 2002

T. T. J. KIRCHER ,
P. F. LIDDLE ,
M. J. BRAMMER ,
S. C. R. WILLIAMS ,
R. M. MURRAY  and
P. K. McGUIRE
T. T. J. KIRCHER
Affiliation:
From the Department of Psychiatry, University of Tübingen, Tübingen, Germany; Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London and Department of Psychiatry, University of Nottingham, Nottingham
P. F. LIDDLE
Affiliation:
From the Department of Psychiatry, University of Tübingen, Tübingen, Germany; Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London and Department of Psychiatry, University of Nottingham, Nottingham
M. J. BRAMMER
Affiliation:
From the Department of Psychiatry, University of Tübingen, Tübingen, Germany; Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London and Department of Psychiatry, University of Nottingham, Nottingham
S. C. R. WILLIAMS
Affiliation:
From the Department of Psychiatry, University of Tübingen, Tübingen, Germany; Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London and Department of Psychiatry, University of Nottingham, Nottingham
R. M. MURRAY
Affiliation:
From the Department of Psychiatry, University of Tübingen, Tübingen, Germany; Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London and Department of Psychiatry, University of Nottingham, Nottingham
P. K. McGUIRE
Affiliation:
From the Department of Psychiatry, University of Tübingen, Tübingen, Germany; Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London and Department of Psychiatry, University of Nottingham, Nottingham
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Abstract

Background. Formal thought disorder is a core symptom of schizophrenia. It is associated with a reversed lateralization of the superior temporal cortex volume, an area that is implicated in lexical retrieval. We investigated the neural correlates of word retrieval during continuous speech in patients with formal thought disorder using functional magnetic resonance imaging (fMRI).

Methods. Blood oxygenation level dependent (BOLD) contrast was measured with fMRI while six patients with schizophrenia and six healthy control subjects spoke about seven Rorschach inkblots for 3 min each. Subjects produced varying amounts of speech during each run. In a within subject design, the number of words produced was correlated with the BOLD contrast in the two runs in each participant who showed the highest variance of speech output.

Results. In control subjects, the amount of speech produced was mainly correlated with activation in the left superior temporal gyrus. In the patient group, the main correlations were in the right superior temporal gyrus.

Conclusions. During the production of continuous speech, patients with formal thought disorder showed a reversed laterality of activation in the superior temporal cortex. This is consistent with findings of perturbed hemispheric interaction in schizophrenia, particularly in patients with formal thought disorder.

Type
Original Article
Information
Psychological Medicine , Volume 32 , Issue 3 , April 2002 , pp. 439 - 449
Copyright
© 2002 Cambridge University Press

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