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Mental development of phenylketonuric children on or off diet after the age of six

Published online by Cambridge University Press:  09 July 2009

Eleanor S. Brown  and
Robert Warner
Eleanor S. Brown*
Affiliation:
Department of Pediatrics and the Waisman Center on Mental Retardation and Human Development, University of Wisconsin, Madison, and the Children's Rehabilitation Center, Children's Hospital, Buffalo, New York
Robert Warner
Affiliation:
Department of Pediatrics and the Waisman Center on Mental Retardation and Human Development, University of Wisconsin, Madison, and the Children's Rehabilitation Center, Children's Hospital, Buffalo, New York
*
1Address for correspondence: Eleanor S. Brown, Ph.D., Department of Pediatrics and Waisman Center on Mental Retardation and Human Development, University of Wisconsin, 2605 Marsh Lane, Madison, W1 53706.
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Synopsis

Eleven children with phenylketonuria (PKU) taken off diet after the age of six showed significant decreases in rate of mental development compared with 26 control children of comparable IQ and with 17 PKU children of comparable IQ who remained on the diet. Changes in rate of mental development were significantly and inversely correlated with plasma phenylalanine levels in treated PKU.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 2 , May 1976 , pp. 287 - 296
Copyright
Copyright © Cambridge University Press 1976

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References

REFERENCES

Belton, N. R., Crombie, J. D., Robins, S. P., Stephen, R. & Farquhar, J. W. (1973). Measurement of phenylalanine in routine care of phenylketonuric children. Archives of Diseease in Childhood 48, 472–475.CrossRefGoogle ScholarPubMed
Berman, P. W., Waisman, H. A. & Graham, F. K. (1966). Intelligence in treated phenylketonuric children: a developmental study. Child Development 37, 731–747.CrossRefGoogle Scholar
Bickel, H. & Kaiser-Grubel, S. (1971) Über die Phenylketonurie. Deutsche medizinische Wochenschrift 96, 1415–1423.CrossRefGoogle Scholar
Bloom, B. S. (1964). Stability and Change in Human Characteristics. Wiley: New York.Google Scholar
Cabalska, B., Duczyńska, N., Golabek, B., Koślacz-Folga, A. & Zorska, K. (1975). Tentative criteria for terminating the low-phenylalanine diet in PKU. Third Congress of the International Association for the Scientific Study of Mental Deficiency. The Hague, Netherlands.Google Scholar
Dobbing, J. & Sands, J. (1973). Quantitative growth and development of human brain. Archives of Disease in Childhood 48, 757–767.CrossRefGoogle ScholarPubMed
Fuller, R. N. & Shuman, J. B. (1969). Phenylketonuria and intelligence: trimodal response to dietary treatment. Nature 221, 639–642.CrossRefGoogle ScholarPubMed
Hackney, I. M., Hanley, W. B., Davidson, W. & Linsao, L. (1968). Phenylketonuria: mental development, behaviour, and termination of low phenylalanine diet. Journal of Pediatrics 72, 646–655.CrossRefGoogle ScholarPubMed
Hanley, W. B. & Linsao, L. (1973). Termination of PKU dietary therapy in 62 patients. Pediatric Research, 7, 383.Google Scholar
Johnson, C. F. (1972). What is the best age to discontinue the low phenylalanine diet in phenylketonuria? Clinical Pediatrics 11, 148–156.CrossRefGoogle ScholarPubMed
Kaes, T. (1907). Die Grosshirnrinde des Menschen. Fischer: Jena.Google Scholar
Ljung, B.-O. (1965). The Adolescent Spurt in Mental Growth. Almqvist & Wiksell: Stockholm.Google Scholar
Pinneau, S. R. (1961). Changes in Intelligence Quotient. Houghton Mifflin: Boston.Google Scholar
Smith, B. A. & Waisman, H. A. (1971). Adequate phenylalanine intake for optimum growth and development in the treatment of phenylketonuria. American Journal of Clinical Nutrition 24, 423–431.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1971). Statistical Methods, 6th ed.Iowa State University Press: Ames, Iowa.Google Scholar
Solomons, G., Keleske, L. & Opitz, E. (1966). Evaluation of the effects of terminating the diet in phenylketonuria. Journal of Pediatrics 69, 596–602.CrossRefGoogle ScholarPubMed
Terman, L. M. & Merrill, M. A. (1972). Stanford-Binet Intelligence Scale. Houghton Mifflin: Boston.Google Scholar
Wong, P. W. K., O'Flynn, M. E. & Inouye, T. (1964). Micro-methods for measuring phenylalanine and tyrosine in serum. Clinical Chemistry 10, 1098–1104.CrossRefGoogle Scholar
Wechsler, D. (1951). Equivalent test and mental ages for the WISC. Journal of Consulting Psychology 15, 381–384.CrossRefGoogle ScholarPubMed