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Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study

Published online by Cambridge University Press:  27 April 2012

C. Trzesniak ,
M. S. Schaufelberger ,
F. L. S. Duran ,
L. C. Santos ,
P. G. P. Rosa ,
P. K. McGuire ,
R. M. Murray ,
M. Scazufca ,
P. R. Menezes  and
J. E. C. Hallak
...Show all authors
C. Trzesniak*
Affiliation:
Department of Neuroscience and Behavioural Science, Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil and INCT Translational Medicine, Brazil Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
M. S. Schaufelberger
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
F. L. S. Duran
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
L. C. Santos
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
P. G. P. Rosa
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
P. K. McGuire
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
R. M. Murray
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
M. Scazufca
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
P. R. Menezes
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
J. E. C. Hallak
Affiliation:
Department of Neuroscience and Behavioural Science, Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil and INCT Translational Medicine, Brazil
J. A. S. Crippa
Affiliation:
Department of Neuroscience and Behavioural Science, Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil and INCT Translational Medicine, Brazil
G. F. Busatto
Affiliation:
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil
*
*Address for correspondence: Dr C. Trzesniak, Departamento de Neurociências e Ciências do Comportamento, FMRP-USP, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil. (Email: [email protected])
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Abstract

Background

Neurodevelopmental alterations have been described inconsistently in psychosis probably because of lack of standardization among studies. The aim of this study was to conduct the first longitudinal and population-based magnetic resonance imaging (MRI) evaluation of the presence and size of the cavum septum pellucidum (CSP) and adhesio interthalamica (AI) in a large sample of patients with first-episode psychosis (FEP).

Method

FEP patients (n=122) were subdivided into schizophrenia (n=62), mood disorders (n=46) and other psychosis (n=14) groups and compared to 94 healthy next-door neighbour controls. After 13 months, 80 FEP patients and 52 controls underwent a second MRI examination.

Results

We found significant reductions in the AI length in schizophrenia FEP in comparison with the mood disorders and control subgroups (longer length) at the baseline assessment, and no differences in any measure of the CSP. By contrast, there was a diagnosis×time interaction for the CSP length, with a more prominent increase for this measure in the psychosis group. There was an involution of the AI length over time for all groups but no diagnosis×time interaction.

Conclusions

Our findings suggest that the CSP per se may not be linked to the neurobiology of emerging psychotic disorders, although it might be related to the progression of the disease. However, the fact that the AI length was shown to be shorter at the onset of the disorder supports the neurodevelopmental model of schizophrenia and indicates that an alteration in this grey matter junction may be a risk factor for developing psychosis.

Keywords

Adhesio interthalamicacavum septum pellucidumfirst-episode psychosismagnetic resonance imagingschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 12 , December 2012 , pp. 2523 - 2534
Copyright
Copyright © Cambridge University Press 2012

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