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History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study

Published online by Cambridge University Press:  03 July 2013

M. E. Beutel ,
J. Wiltink ,
Y. Kirschner ,
C. Sinning ,
C. Espinola-Klein ,
P. S. Wild ,
T. Münzel ,
M. Blettner ,
I. Zwiener  and
K. Lackner
...Show all authors
M. E. Beutel
Affiliation:
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
J. Wiltink
Affiliation:
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
Y. Kirschner
Affiliation:
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany Department of Medicine II, University Medical Center of the Johannes Gutenberg University Mainz, Germany
C. Sinning
Affiliation:
Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
C. Espinola-Klein
Affiliation:
Department of Medicine II, University Medical Center of the Johannes Gutenberg University Mainz, Germany
P. S. Wild
Affiliation:
Department of Medicine II, University Medical Center of the Johannes Gutenberg University Mainz, Germany Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Germany
T. Münzel
Affiliation:
Department of Medicine II, University Medical Center of the Johannes Gutenberg University Mainz, Germany
M. Blettner
Affiliation:
Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Germany
I. Zwiener
Affiliation:
Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Germany
K. Lackner
Affiliation:
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Germany
M. Michal*
Affiliation:
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Germany
*
*Address for correspondence: M. Michal, M.D., Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. (Email: [email protected])
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Abstract

Objectives

To test the vascular depression hypothesis in the general population, we analyzed the association between current depression, medical history of depression, cognitive and somatic depressive symptom dimensions and measures of atherosclerosis [intima–media thickness (IMT) and carotid plaques].

Method

We included a representative sample of 5000 participants from the Gutenberg Health Study (GHS). Depression was assessed by the nine-item Patient Health Questionnaire (PHQ-9), and IMT and carotid plaques were measured at both common carotid arteries using an edge detection system. Regression analyses were performed separately for participants with and without cardiovascular disease, adjusting for medical history, cardiovascular risk factors and psychotropic medication.

Results

Contrary to hypotheses, we found no increased IMT for somatic symptoms of depression; the same was true for depression and cognitive symptoms in the fully adjusted model. Only a moderate relationship between medical history of depression and the presence of atherosclerotic plaques was maintained after correction.

Conclusions

The relationship between depression and atherosclerosis may be more complex than previously assumed. Although the vascular depression hypothesis was not supported, our results support the hypothesis that lasting depression leads to arteriosclerosis.

Keywords

Cardiovascular diseasecarotid plaquesdepressionintima–media thickness
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 5 , April 2014 , pp. 919 - 925
Copyright
Copyright © Cambridge University Press 2013 

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References

Ainsworth, BE, Haskell, WL, Leon, AS, Jacobs, DR Jr., Montoye, HJ, Sallis, JF, Paffenbarger, RS Jr. (1993). Compendium of physical activities: classification of energy costs of human physical activities. Medicine and Science in Sports and Exercise 25, 71–80.CrossRefGoogle ScholarPubMed
Bus, BA, Marijnissen, RM, Holewijn, S, Franke, B, Purandare, N, de Graaf, J, den Heijer, M, Buitelaar, JK, Voshaar, RC (2011). Depressive symptom clusters are differentially associated with atherosclerotic disease. Psychological Medicine 41, 1419–1428.CrossRefGoogle ScholarPubMed
Elovainio, M, Keltikangas-Järvinen, L, Kivimäki, M, Pulkki, L, Puttonen, S, Heponiemi, T, Juonala, M, Viikari, JS, Raitakari, OT (2005). Depressive symptoms and carotid artery intima-media thickness in young adults: the Cardiovascular Risk in Young Finns Study. Psychosomatic Medicine 67, 561–567.Google Scholar
Hoen, PW, Whooley, MA, Martens, EJ, Na, B, van Melle, JP, de Jonge, P (2010). Differential associations between specific depressive symptoms and cardiovascular prognosis in patients with stable coronary heart disease. Journal of the American College of Cardiology 56, 838–844.Google Scholar
Kuper, H, Nicholson, A, Kivimaki, M, Aitsi-Selmi, A, Cavalleri, G, Deanfield, JE, Heuschmann, P, Jouven, X, Malyutina, S, Mayosi, BM, Sans, S, Thomsen, T, Witteman, JC, Hingorani, AD, Lawlor, DA, Hemingway, H (2009). Evaluating the causal relevance of diverse risk markers: horizontal systematic review. British Medical Journal 339, b4265.Google Scholar
Lampert, T, Kroll, LE (2009). Die Messung des sozioökonomischen Status in sozialepidemiologischen Studien. In Gesundheitliche Ungleichheit (ed. Richter, M. and Hurrelmann, K.), pp. 309–334. VS Verlag für Sozialwissenschaften: Wiesbaden.Google Scholar
Lowe, B, Grafe, K, Zipfel, S, Witte, S, Loerch, B, Herzog, W (2004). Diagnosing ICD-10 depressive episodes: superior criterion validity of the Patient Health Questionnaire. Psychotherapy and Psychosomatics 73, 386–390.CrossRefGoogle ScholarPubMed
Martens, EJ, Hoen, PW, Mittelhaeuser, M, de Jonge, P, Denollet, J (2010). Symptom dimensions of post-myocardial infarction depression, disease severity and cardiac prognosis. Psychological Medicine 40, 807–814.Google Scholar
Ormel, J, de Jonge, P (2011). Unipolar depression and the progression of coronary artery disease: toward an integrative model. Psychotherapy and Psychosomatics 80, 264–274.Google Scholar
Pizzi, C, Manzoli, L, Mancini, S, Bedetti, G, Fontana, F, Costa, GM (2010). Autonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors. Atherosclerosis 212, 292–298.Google Scholar
Poole, L, Dickens, C, Steptoe, A (2011). The puzzle of depression and acute coronary syndrome: reviewing the role of acute inflammation. Journal of Psychosomatic Research 71, 61–68.Google Scholar
Sinning, C, Wild, PS, Echevarria, FM, Wilde, S, Schnabel, R, Lubos, E, Herkenhoff, S, Bickel, C, Klimpe, S, Gori, T, Münzel, TF, Blankenberg, S, Espinola-Klein, C (2011). Sex differences in early carotid atherosclerosis (from the community-based Gutenberg-Heart Study). American Journal of Cardiology 107, 1841–1847.Google Scholar
Smith, PJ, Blumenthal, JA, Babyak, MA, Doraiswamy, PM, Hinderliter, A, Hoffman, BM, Waugh, R, Sherwood, A (2009). Intima-media thickness and age of first depressive episode. Biological Psychology 80, 361–364.CrossRefGoogle ScholarPubMed
Wendel-Vos, GC, Schuit, AJ, Saris, WH, Kromhout, D (2003). Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. Journal of Clinical Epidemiology 56, 1163–1169.CrossRefGoogle ScholarPubMed
Whipple, MO, Lewis, TT, Sutton-Tyrrell, K, Matthews, KA, Barinas-Mitchell, E, Powell, LH, Everson-Rose, SA (2009). Hopelessness, depressive symptoms, and carotid atherosclerosis in women: the Study of Women's Health Across the Nation (SWAN) heart study. Stroke 40, 3166–3172.Google Scholar
Ye, S, Muntner, P, Shimbo, D, Judd, SE, Richman, J, Davidson, KW, Safford, MM (2013). Behavioral mechanisms, elevated depressive symptoms, and the risk for myocardial infarction or death in individuals with coronary heart disease: the REGARDS (Reason for Geographic and Racial Differences in Stroke) Study. Journal of the American College of Cardiology 12, 622–630.Google Scholar