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The DSM-5 proposal for attenuated psychosis syndrome: a history

Published online by Cambridge University Press:  01 April 2020

Peter Zachar Open the ORCID record for Peter Zachar [Opens in a new window] ,
Michael B. First  and
Kenneth S. Kendler
Peter Zachar
Affiliation:
Department of Psychology, Auburn University Montgomery, Montgomery, AL, USA
Michael B. First
Affiliation:
Department of Psychiatry, Columbia University, New York, NY, USA
Kenneth S. Kendler*
Affiliation:
Virginia Institute for Psychiatry and Behavioral Genetics and Departments of Psychiatry, and Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA
*
Author for correspondence: Kenneth S. Kendler, E-mail: [email protected]
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Abstract

This article narrates a consensus history of the proposal to include diagnostic criteria for a psychosis risk syndrome in the DSM-5, in part, to document what happened, but also to potentially help focus future efforts at clinically useful early detection. The purpose of diagnosing a risk state would be to slow and ideally prevent the development of the full disorder. Concerns about diagnosing a psychosis risk state included a high false positive rate, potentially harmful use of anti-psychotic medication with people who would not transition to psychosis, and stigmatization. Others argued that educating professionals about what ‘risk’ entails could reduce inappropriate treatments. During the revision, the proposal shifted from diagnosing risk to emphasizing current clinical need associated with attenuated psychotic symptoms. Within the community of researchers who studied psychosis risk, people disagreed about whether risk and/or attenuated symptoms should be an official DSM-5 diagnosis. Once it became clear that the DSM-5 field trials did not include enough cases to establish the reliability of the proposed criteria, everyone agreed that the criteria should be put in a section on conditions for further study rather the main section of the DSM-5. We close with recommendations about some practical benchmarks that should be met for including criteria for early detection in the classification system.

Keywords

At-risk mental statebasic symptomsprodromepsychosisschizophreniaultra-high risk
Type
Review Article
Information
Psychological Medicine , Volume 50 , Issue 6 , April 2020 , pp. 920 - 926
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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