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Brain correlates of recognition of communicative interactions from biological motion in schizophrenia

Published online by Cambridge University Press:  27 November 2017

Ł. Okruszek ,
M. Wordecha ,
M. Jarkiewicz ,
B. Kossowski ,
J. Lee  and
A. Marchewka
Ł. Okruszek*
Affiliation:
Faculty of Psychology, University of Warsaw, Warsaw, Poland
M. Wordecha
Affiliation:
Clinical Neuroscience Lab, Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland
M. Jarkiewicz
Affiliation:
Institute of Psychiatry and Neurology, Warsaw, Poland
B. Kossowski
Affiliation:
Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
J. Lee
Affiliation:
Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
A. Marchewka
Affiliation:
Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
*
Author of correspondence: Ł. Okruszek, Email: [email protected]
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Abstract

Background

Recognition of communicative interactions is a complex social cognitive ability which is associated with a specific neural activity in healthy individuals. However, neural correlates of communicative interaction processing from whole-body motion have not been known in patients with schizophrenia (SCZ). Therefore, the current study aims to examine the neural activity associated with recognition of communicative interactions in SCZ by using displays of the dyadic interactions downgraded to minimalistic point-light presentations.

Methods

Twenty-six healthy controls (HC) and 25 SCZ were asked to judge whether two agents presented only by point-light displays were communicating or acting independently. Task-related activity and functional connectivity of brain structures were examined with General Linear Model and Generalized Psychophysiological Interaction approach, respectively.

Results

HC were significantly more efficient in recognizing each type of action than SCZ. At the neural level, the activity of the right posterior superior temporal sulcus (pSTS) was observed to be higher in HC compared with SCZ for communicative v. individual action processing. Importantly, increased connectivity of the right pSTS with structures associated with mentalizing (left pSTS) and mirroring networks (left frontal areas) was observed in HC, but not in SCZ, during the presentation of social interactions.

Conclusion

Under-recruitment of the right pSTS, a structure known to have a pivotal role in social processing, may also be of importance for higher-order social cognitive deficits in SCZ. Furthermore, decreased task-related connectivity of the right pSTS may result in reduced use of additional sources of information (for instance motor resonance signals) during social cognitive processing in schizophrenia.

Keywords

Mentalizingmirroringposterior superior temporal sulcuspSTSpsychophysiological interaction (PPI)social cognitionsocial interactions
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 11 , August 2018 , pp. 1862 - 1871
Copyright
Copyright © Cambridge University Press 2017 

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